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A pilot study of the effects of phytoestrogen supplementation on postmenopausal endometrium.
J Soc Gynecol Investig. 2002 Jul-Aug; 9(4):238-42.JS

Abstract

OBJECTIVE

This study was designed to assess endometrial histology in postmenopausal women not taking hormone replacement therapy, to evaluate side effects and efficacy of phytoestrogens in treating menopause-associated symptoms, and to determine whether 6 months of phytoestrogen supplementation altered endometrial histology.

METHODS

We performed a prospective, double-blinded, randomized, placebo-controlled trial comparing the effects of 6 months of dietary phytoestrogen supplementation versus placebo in postmenopausal women. Baseline endometrial biopsies were performed and, if adequate, nonhyperplastic, noncancerous, and nonovulatory, subjects were randomly assigned to receive daily placebo or soy cereal supplementation for 6 months. Study subjects completed baseline and weekly dietary, symptom, and side effect logs. Repeat endometrial biopsies were obtained at 6 months.

RESULTS

Subjects were recruited from January 1998 through June 2000. Twenty-seven subjects were randomized, and 19 completed the study. One (3.7%) baseline endometrial sample was weakly proliferative. All other baseline and final biopsies were consistent with atrophic, inactive endometrium. The maximum risk of endometrial stimulation with phytoestrogens is 35%. Hot flushes, night sweats, and vaginal dryness were significantly less severe at the final week of the study compared with baseline in the placebo group. Insomnia was more common in the treated group. There were no other statistically significant differences in symptoms or side effects.

CONCLUSION

Phytoestrogens did not cause stimulation of the endometrium. Insomnia was more frequent over the 6-month study in the soy group, whereas hot flushes, night sweats, and vaginal dryness improved from baseline in the placebo group but not in the soy group.

Authors+Show Affiliations

Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee-Womens Hospital, University of Pittsburgh, Pennsylvania 15213, USA. rsijlb@mail.magee.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

12113884

Citation

Balk, Judith L., et al. "A Pilot Study of the Effects of Phytoestrogen Supplementation On Postmenopausal Endometrium." Journal of the Society for Gynecologic Investigation, vol. 9, no. 4, 2002, pp. 238-42.
Balk JL, Whiteside DA, Naus G, et al. A pilot study of the effects of phytoestrogen supplementation on postmenopausal endometrium. J Soc Gynecol Investig. 2002;9(4):238-42.
Balk, J. L., Whiteside, D. A., Naus, G., DeFerrari, E., & Roberts, J. M. (2002). A pilot study of the effects of phytoestrogen supplementation on postmenopausal endometrium. Journal of the Society for Gynecologic Investigation, 9(4), 238-42.
Balk JL, et al. A Pilot Study of the Effects of Phytoestrogen Supplementation On Postmenopausal Endometrium. J Soc Gynecol Investig. 2002;9(4):238-42. PubMed PMID: 12113884.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A pilot study of the effects of phytoestrogen supplementation on postmenopausal endometrium. AU - Balk,Judith L, AU - Whiteside,Deborah A, AU - Naus,Gregory, AU - DeFerrari,Emily, AU - Roberts,James M, PY - 2002/7/13/pubmed PY - 2002/12/31/medline PY - 2002/7/13/entrez SP - 238 EP - 42 JF - Journal of the Society for Gynecologic Investigation JO - J. Soc. Gynecol. Investig. VL - 9 IS - 4 N2 - OBJECTIVE: This study was designed to assess endometrial histology in postmenopausal women not taking hormone replacement therapy, to evaluate side effects and efficacy of phytoestrogens in treating menopause-associated symptoms, and to determine whether 6 months of phytoestrogen supplementation altered endometrial histology. METHODS: We performed a prospective, double-blinded, randomized, placebo-controlled trial comparing the effects of 6 months of dietary phytoestrogen supplementation versus placebo in postmenopausal women. Baseline endometrial biopsies were performed and, if adequate, nonhyperplastic, noncancerous, and nonovulatory, subjects were randomly assigned to receive daily placebo or soy cereal supplementation for 6 months. Study subjects completed baseline and weekly dietary, symptom, and side effect logs. Repeat endometrial biopsies were obtained at 6 months. RESULTS: Subjects were recruited from January 1998 through June 2000. Twenty-seven subjects were randomized, and 19 completed the study. One (3.7%) baseline endometrial sample was weakly proliferative. All other baseline and final biopsies were consistent with atrophic, inactive endometrium. The maximum risk of endometrial stimulation with phytoestrogens is 35%. Hot flushes, night sweats, and vaginal dryness were significantly less severe at the final week of the study compared with baseline in the placebo group. Insomnia was more common in the treated group. There were no other statistically significant differences in symptoms or side effects. CONCLUSION: Phytoestrogens did not cause stimulation of the endometrium. Insomnia was more frequent over the 6-month study in the soy group, whereas hot flushes, night sweats, and vaginal dryness improved from baseline in the placebo group but not in the soy group. SN - 1071-5576 UR - https://www.unboundmedicine.com/medline/citation/12113884/A_pilot_study_of_the_effects_of_phytoestrogen_supplementation_on_postmenopausal_endometrium_ DB - PRIME DP - Unbound Medicine ER -