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Antioxidant responses to oxidant-mediated lung diseases.
Am J Physiol Lung Cell Mol Physiol 2002; 283(2):L246-55AJ

Abstract

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated throughout the human body. Enzymatic and nonenzymatic antioxidants detoxify ROS and RNS and minimize damage to biomolecules. An imbalance between the production of ROS and RNS and antioxidant capacity leads to a state of "oxidative stress" that contributes to the pathogenesis of a number of human diseases by damaging lipids, protein, and DNA. In general, lung diseases are related to inflammatory processes that generate increased ROS and RNS. The susceptibility of the lung to oxidative injury depends largely on its ability to upregulate protective ROS and RNS scavenging systems. Unfortunately, the primary intracellular antioxidants are expressed at low levels in the human lung and are not acutely induced when exposed to oxidative stresses such as cigarette smoke and hyperoxia. However, the response of extracellular antioxidant enzymes, the critical primary defense against exogenous oxidative stress, increases rapidly and in proportion to oxidative stress. In this paper, we review how antioxidants in the lung respond to oxidative stress in several lung diseases and focus on the mechanisms that upregulate extracellular glutathione peroxidase.

Authors+Show Affiliations

Department of Pulmonary and Critical Care Medicine, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA. comhais@ccf.orgNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

12114185

Citation

Comhair, Suzy A A., and Serpil C. Erzurum. "Antioxidant Responses to Oxidant-mediated Lung Diseases." American Journal of Physiology. Lung Cellular and Molecular Physiology, vol. 283, no. 2, 2002, pp. L246-55.
Comhair SA, Erzurum SC. Antioxidant responses to oxidant-mediated lung diseases. Am J Physiol Lung Cell Mol Physiol. 2002;283(2):L246-55.
Comhair, S. A., & Erzurum, S. C. (2002). Antioxidant responses to oxidant-mediated lung diseases. American Journal of Physiology. Lung Cellular and Molecular Physiology, 283(2), pp. L246-55.
Comhair SA, Erzurum SC. Antioxidant Responses to Oxidant-mediated Lung Diseases. Am J Physiol Lung Cell Mol Physiol. 2002;283(2):L246-55. PubMed PMID: 12114185.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant responses to oxidant-mediated lung diseases. AU - Comhair,Suzy A A, AU - Erzurum,Serpil C, PY - 2002/7/13/pubmed PY - 2002/8/13/medline PY - 2002/7/13/entrez SP - L246 EP - 55 JF - American journal of physiology. Lung cellular and molecular physiology JO - Am. J. Physiol. Lung Cell Mol. Physiol. VL - 283 IS - 2 N2 - Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated throughout the human body. Enzymatic and nonenzymatic antioxidants detoxify ROS and RNS and minimize damage to biomolecules. An imbalance between the production of ROS and RNS and antioxidant capacity leads to a state of "oxidative stress" that contributes to the pathogenesis of a number of human diseases by damaging lipids, protein, and DNA. In general, lung diseases are related to inflammatory processes that generate increased ROS and RNS. The susceptibility of the lung to oxidative injury depends largely on its ability to upregulate protective ROS and RNS scavenging systems. Unfortunately, the primary intracellular antioxidants are expressed at low levels in the human lung and are not acutely induced when exposed to oxidative stresses such as cigarette smoke and hyperoxia. However, the response of extracellular antioxidant enzymes, the critical primary defense against exogenous oxidative stress, increases rapidly and in proportion to oxidative stress. In this paper, we review how antioxidants in the lung respond to oxidative stress in several lung diseases and focus on the mechanisms that upregulate extracellular glutathione peroxidase. SN - 1040-0605 UR - https://www.unboundmedicine.com/medline/citation/12114185/Antioxidant_responses_to_oxidant_mediated_lung_diseases_ L2 - http://www.physiology.org/doi/full/10.1152/ajplung.00491.2001?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -