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Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor.
Science. 2002 Jul 12; 297(5579):259-63.Sci

Abstract

Poly(ADP-ribose) polymerase-1 (PARP-1) protects the genome by functioning in the DNA damage surveillance network. PARP-1 is also a mediator of cell death after ischemia-reperfusion injury, glutamate excitotoxicity, and various inflammatory processes. We show that PARP-1 activation is required for translocation of apoptosis-inducing factor (AIF) from the mitochondria to the nucleus and that AIF is necessary for PARP-1-dependent cell death. N-methyl-N'-nitro-N-nitrosoguanidine, H2O2, and N-methyl-d-aspartate induce AIF translocation and cell death, which is prevented by PARP inhibitors or genetic knockout of PARP-1, but is caspase independent. Microinjection of an antibody to AIF protects against PARP-1-dependent cytotoxicity. These data support a model in which PARP-1 activation signals AIF release from mitochondria, resulting in a caspase-independent pathway of programmed cell death.

Authors+Show Affiliations

Department of Neurology and Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12114629

Citation

Yu, Seong-Woon, et al. "Mediation of poly(ADP-ribose) Polymerase-1-dependent Cell Death By Apoptosis-inducing Factor." Science (New York, N.Y.), vol. 297, no. 5579, 2002, pp. 259-63.
Yu SW, Wang H, Poitras MF, et al. Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science. 2002;297(5579):259-63.
Yu, S. W., Wang, H., Poitras, M. F., Coombs, C., Bowers, W. J., Federoff, H. J., Poirier, G. G., Dawson, T. M., & Dawson, V. L. (2002). Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science (New York, N.Y.), 297(5579), 259-63.
Yu SW, et al. Mediation of poly(ADP-ribose) Polymerase-1-dependent Cell Death By Apoptosis-inducing Factor. Science. 2002 Jul 12;297(5579):259-63. PubMed PMID: 12114629.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. AU - Yu,Seong-Woon, AU - Wang,Hongmin, AU - Poitras,Marc F, AU - Coombs,Carmen, AU - Bowers,William J, AU - Federoff,Howard J, AU - Poirier,Guy G, AU - Dawson,Ted M, AU - Dawson,Valina L, PY - 2002/7/13/pubmed PY - 2002/8/3/medline PY - 2002/7/13/entrez SP - 259 EP - 63 JF - Science (New York, N.Y.) JO - Science VL - 297 IS - 5579 N2 - Poly(ADP-ribose) polymerase-1 (PARP-1) protects the genome by functioning in the DNA damage surveillance network. PARP-1 is also a mediator of cell death after ischemia-reperfusion injury, glutamate excitotoxicity, and various inflammatory processes. We show that PARP-1 activation is required for translocation of apoptosis-inducing factor (AIF) from the mitochondria to the nucleus and that AIF is necessary for PARP-1-dependent cell death. N-methyl-N'-nitro-N-nitrosoguanidine, H2O2, and N-methyl-d-aspartate induce AIF translocation and cell death, which is prevented by PARP inhibitors or genetic knockout of PARP-1, but is caspase independent. Microinjection of an antibody to AIF protects against PARP-1-dependent cytotoxicity. These data support a model in which PARP-1 activation signals AIF release from mitochondria, resulting in a caspase-independent pathway of programmed cell death. SN - 1095-9203 UR - https://www.unboundmedicine.com/medline/citation/12114629/Mediation_of_poly_ADP_ribose__polymerase_1_dependent_cell_death_by_apoptosis_inducing_factor_ L2 - https://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=12114629 DB - PRIME DP - Unbound Medicine ER -