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A randomized, double-blind study of the efficacy of a 10- or 20-day course of sodium stibogluconate for treatment of cutaneous leishmaniasis in United States military personnel.
Clin Infect Dis. 2002 Aug 01; 35(3):261-7.CI

Abstract

The recommended treatment for cutaneous leishmaniasis is pentavalent antimony at a dosage of 20 mg/kg/day for 20 days. Some studies conducted in locales in which Leishmania is endemic have suggested that shorter courses of treatment may be as efficacious. We conducted a randomized, double-blind, placebo-controlled study of 10 versus 20 days of sodium stibogluconate (SSG) in United States military personnel who contracted cutaneous leishmaniasis while serving overseas; 19 patients received SSG for 10 days (and placebo for 10 days), and 19 patients received SSG for 20 days. Cure rates were 100% (19 of 19 patients) in the 10-day group and 95% (18 of 19 patients) in the 20-day group. Side effects were more common among patients who received 20 days of therapy. In this group of otherwise healthy young adults, SSG at a dosage of 20 mg/kg/day for 10 days appears to have been therapeutically equivalent and less toxic than the standard 20-day course.

Authors+Show Affiliations

Division of Infectious Diseases, Walter Reed Army Medical Center, Washington, DC, USA. Gllenn.Wortmann@na.amedd.army.milNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

12115091

Citation

Wortmann, Glenn, et al. "A Randomized, Double-blind Study of the Efficacy of a 10- or 20-day Course of Sodium Stibogluconate for Treatment of Cutaneous Leishmaniasis in United States Military Personnel." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 35, no. 3, 2002, pp. 261-7.
Wortmann G, Miller RS, Oster C, et al. A randomized, double-blind study of the efficacy of a 10- or 20-day course of sodium stibogluconate for treatment of cutaneous leishmaniasis in United States military personnel. Clin Infect Dis. 2002;35(3):261-7.
Wortmann, G., Miller, R. S., Oster, C., Jackson, J., & Aronson, N. (2002). A randomized, double-blind study of the efficacy of a 10- or 20-day course of sodium stibogluconate for treatment of cutaneous leishmaniasis in United States military personnel. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 35(3), 261-7.
Wortmann G, et al. A Randomized, Double-blind Study of the Efficacy of a 10- or 20-day Course of Sodium Stibogluconate for Treatment of Cutaneous Leishmaniasis in United States Military Personnel. Clin Infect Dis. 2002 Aug 1;35(3):261-7. PubMed PMID: 12115091.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A randomized, double-blind study of the efficacy of a 10- or 20-day course of sodium stibogluconate for treatment of cutaneous leishmaniasis in United States military personnel. AU - Wortmann,Glenn, AU - Miller,R Scott, AU - Oster,Charles, AU - Jackson,Joan, AU - Aronson,Naomi, Y1 - 2002/07/10/ PY - 2001/11/27/received PY - 2002/03/12/revised PY - 2002/7/13/pubmed PY - 2002/8/6/medline PY - 2002/7/13/entrez SP - 261 EP - 7 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin Infect Dis VL - 35 IS - 3 N2 - The recommended treatment for cutaneous leishmaniasis is pentavalent antimony at a dosage of 20 mg/kg/day for 20 days. Some studies conducted in locales in which Leishmania is endemic have suggested that shorter courses of treatment may be as efficacious. We conducted a randomized, double-blind, placebo-controlled study of 10 versus 20 days of sodium stibogluconate (SSG) in United States military personnel who contracted cutaneous leishmaniasis while serving overseas; 19 patients received SSG for 10 days (and placebo for 10 days), and 19 patients received SSG for 20 days. Cure rates were 100% (19 of 19 patients) in the 10-day group and 95% (18 of 19 patients) in the 20-day group. Side effects were more common among patients who received 20 days of therapy. In this group of otherwise healthy young adults, SSG at a dosage of 20 mg/kg/day for 10 days appears to have been therapeutically equivalent and less toxic than the standard 20-day course. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/12115091/A_randomized_double_blind_study_of_the_efficacy_of_a_10__or_20_day_course_of_sodium_stibogluconate_for_treatment_of_cutaneous_leishmaniasis_in_United_States_military_personnel_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1086/341406 DB - PRIME DP - Unbound Medicine ER -