Tags

Type your tag names separated by a space and hit enter

Incidence of cancer among patients with knee implants in Sweden, 1980-1994.
Cancer. 2002 Jun 01; 94(11):3057-62.C

Abstract

BACKGROUND

As knee implants become more common, it is important to study their potential health risks. We investigated cancer occurrence in a nationwide population-based cohort of 30,011 patients who underwent knee replacement surgery in Sweden from 1980 to 1994.

METHODS

Patients were followed from 1 year after the date of their surgery through December 31, 1995, accruing 122,616 person-years of observation. The average follow-up time was 4.3 years, with 2365 patients followed for 10 years or more.

RESULTS

Overall cancer incidence was not elevated compared with the general population of Sweden (standardized incidence ratio [SIR] = 1.03; 95% confidence interval [CI] = 0.98-1.08). A reduced rate for all respiratory cancers (SIR = 0.73; 95% CI = 0.59-0.91) and for lung cancer (SIR = 0.73; 95% CI = 0.58-0.91) was found among both men and women. Elevated rates were found for prostate (SIR = 1.20; 95% CI = 1.06-1.34) and bone cancer (SIR = 6.00; 95% CI = 1.24-17.52) in men. The bone cancer excess was based on three observed cases, two of which occurred at a site unrelated to the implant and the site of the third tumor is unknown. Rates of connective tissue cancer and leukemia-lymphoma were not elevated significantly among knee implant recipients. Long-term follow-up (>or= 10 years) did not show a significant excess risk for all cancer (SIR = 1.10; 95% CI = 0.86-1.38) or for any site-specific cancer, including bone cancer, lymphoma, or leukemia. Subgroup analyses for patients with rheumatoid arthritis produced results similar to the overall results.

CONCLUSIONS

This epidemiologic study of cancer risk among patients with knee implants is the largest to date. It provides evidence that the incidence of cancer among patients with knee implants is similar to that of the general population. Continued follow-up of this cohort is warranted to evaluate further potential long-term effects of these implants.

Authors+Show Affiliations

International Epidemiology Institute, Rockville, Maryland 20850, USA. fryzek@iei.wsNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12115397

Citation

Fryzek, Jon P., et al. "Incidence of Cancer Among Patients With Knee Implants in Sweden, 1980-1994." Cancer, vol. 94, no. 11, 2002, pp. 3057-62.
Fryzek JP, Ye W, Signorello LB, et al. Incidence of cancer among patients with knee implants in Sweden, 1980-1994. Cancer. 2002;94(11):3057-62.
Fryzek, J. P., Ye, W., Signorello, L. B., Lipworth, L., Blot, W. J., McLaughlin, J. K., & Nyren, O. (2002). Incidence of cancer among patients with knee implants in Sweden, 1980-1994. Cancer, 94(11), 3057-62.
Fryzek JP, et al. Incidence of Cancer Among Patients With Knee Implants in Sweden, 1980-1994. Cancer. 2002 Jun 1;94(11):3057-62. PubMed PMID: 12115397.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Incidence of cancer among patients with knee implants in Sweden, 1980-1994. AU - Fryzek,Jon P, AU - Ye,Weimin, AU - Signorello,Lisa B, AU - Lipworth,Loren, AU - Blot,William J, AU - McLaughlin,Joseph K, AU - Nyren,Olof, PY - 2002/7/13/pubmed PY - 2002/8/3/medline PY - 2002/7/13/entrez SP - 3057 EP - 62 JF - Cancer JO - Cancer VL - 94 IS - 11 N2 - BACKGROUND: As knee implants become more common, it is important to study their potential health risks. We investigated cancer occurrence in a nationwide population-based cohort of 30,011 patients who underwent knee replacement surgery in Sweden from 1980 to 1994. METHODS: Patients were followed from 1 year after the date of their surgery through December 31, 1995, accruing 122,616 person-years of observation. The average follow-up time was 4.3 years, with 2365 patients followed for 10 years or more. RESULTS: Overall cancer incidence was not elevated compared with the general population of Sweden (standardized incidence ratio [SIR] = 1.03; 95% confidence interval [CI] = 0.98-1.08). A reduced rate for all respiratory cancers (SIR = 0.73; 95% CI = 0.59-0.91) and for lung cancer (SIR = 0.73; 95% CI = 0.58-0.91) was found among both men and women. Elevated rates were found for prostate (SIR = 1.20; 95% CI = 1.06-1.34) and bone cancer (SIR = 6.00; 95% CI = 1.24-17.52) in men. The bone cancer excess was based on three observed cases, two of which occurred at a site unrelated to the implant and the site of the third tumor is unknown. Rates of connective tissue cancer and leukemia-lymphoma were not elevated significantly among knee implant recipients. Long-term follow-up (>or= 10 years) did not show a significant excess risk for all cancer (SIR = 1.10; 95% CI = 0.86-1.38) or for any site-specific cancer, including bone cancer, lymphoma, or leukemia. Subgroup analyses for patients with rheumatoid arthritis produced results similar to the overall results. CONCLUSIONS: This epidemiologic study of cancer risk among patients with knee implants is the largest to date. It provides evidence that the incidence of cancer among patients with knee implants is similar to that of the general population. Continued follow-up of this cohort is warranted to evaluate further potential long-term effects of these implants. SN - 0008-543X UR - https://www.unboundmedicine.com/medline/citation/12115397/Incidence_of_cancer_among_patients_with_knee_implants_in_Sweden_1980_1994_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0008-543X&date=2002&volume=94&issue=11&spage=3057 DB - PRIME DP - Unbound Medicine ER -