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Sonographic evaluation of mammographically detected microcalcifications without a mass prior to stereotactic core needle biopsy.
J Clin Ultrasound. 2002 Jul-Aug; 30(6):323-31.JC

Abstract

PURPOSE

The purpose of this prospective study was to evaluate the clinical usefulness of sonographically re-evaluating areas of microcalcification found mammographically before undertaking stereotactic core needle biopsy (SCNB).

METHODS

Patients with nonpalpable breast lesions appearing as microcalcifications on mammograms and who had been referred to us for SCNB were re-evaluated sonographically before the procedure. None of the breast lesions had been associated with a density on the mammograms, and the initial sonographic evaluations had been negative. Using the mammograms for correlation, we meticulously re-evaluated the areas of microcalcifications sonographically using a high-frequency linear-array transducer. The sonographic and histopathologic results were then reviewed and correlated. The sonographic findings and visibility of the mammographically detected microcalcifications were analyzed by the 2-tailed Fisher's exact test and the chi-square test.

RESULTS

Sixty-six patients, who had 68 cases of microcalcifications, were enrolled. Thirteen of the 66 patients underwent surgery, and 9 of the 13 were found to have breast carcinoma. In the sonographic re-evaluation before SCNB in these 9 patients, an associated soft tissue mass was demonstrated in 5 patients but not in the other 4. Sonographic re-evaluation also revealed abnormalities in 24 of 68 cases (35.3%), in contrast to the negative findings on the initial sonography. Using the chi-square test to identify a trend, we found that the percentage of cases that were sonographically visible was highest for clustered benign microcalcifications and lowest for segmental benign microcalcifications (p < 0.0001).

CONCLUSIONS

In breast lesions that appear as microcalcifications without an associated mass on mammograms, pre-SCNB sonographic re-evaluation with a high-frequency transducer can depict microcalcifications, particularly the clustered ones, and can detect small associated masses. Although the absence of a sonographically detectable mass in areas of mammographically detected microcalcifications does not guarantee the absence of cancer, the presence of an associated mass on sonography should warrant close follow-up in the case of negative results to avoid a delay in the diagnosis of breast carcinoma.

Authors+Show Affiliations

Department of Diagnostic Radiology, Chang Gung Memorial Hospital, 5 Fu-Hsing Road, Tao Yuan Hsien, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12116093

Citation

Cheung, Yun-Chung, et al. "Sonographic Evaluation of Mammographically Detected Microcalcifications Without a Mass Prior to Stereotactic Core Needle Biopsy." Journal of Clinical Ultrasound : JCU, vol. 30, no. 6, 2002, pp. 323-31.
Cheung YC, Wan YL, Chen SC, et al. Sonographic evaluation of mammographically detected microcalcifications without a mass prior to stereotactic core needle biopsy. J Clin Ultrasound. 2002;30(6):323-31.
Cheung, Y. C., Wan, Y. L., Chen, S. C., Lui, K. W., Ng, S. H., Yeow, K. M., Lee, K. F., & Hsueh, S. (2002). Sonographic evaluation of mammographically detected microcalcifications without a mass prior to stereotactic core needle biopsy. Journal of Clinical Ultrasound : JCU, 30(6), 323-31.
Cheung YC, et al. Sonographic Evaluation of Mammographically Detected Microcalcifications Without a Mass Prior to Stereotactic Core Needle Biopsy. J Clin Ultrasound. 2002 Jul-Aug;30(6):323-31. PubMed PMID: 12116093.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sonographic evaluation of mammographically detected microcalcifications without a mass prior to stereotactic core needle biopsy. AU - Cheung,Yun-Chung, AU - Wan,Yung-Liang, AU - Chen,Shih-Cheh, AU - Lui,Kar-Wai, AU - Ng,Shu-Hang, AU - Yeow,Kee-Min, AU - Lee,Kam-Fai, AU - Hsueh,Swei, PY - 2002/7/13/pubmed PY - 2002/8/17/medline PY - 2002/7/13/entrez SP - 323 EP - 31 JF - Journal of clinical ultrasound : JCU JO - J Clin Ultrasound VL - 30 IS - 6 N2 - PURPOSE: The purpose of this prospective study was to evaluate the clinical usefulness of sonographically re-evaluating areas of microcalcification found mammographically before undertaking stereotactic core needle biopsy (SCNB). METHODS: Patients with nonpalpable breast lesions appearing as microcalcifications on mammograms and who had been referred to us for SCNB were re-evaluated sonographically before the procedure. None of the breast lesions had been associated with a density on the mammograms, and the initial sonographic evaluations had been negative. Using the mammograms for correlation, we meticulously re-evaluated the areas of microcalcifications sonographically using a high-frequency linear-array transducer. The sonographic and histopathologic results were then reviewed and correlated. The sonographic findings and visibility of the mammographically detected microcalcifications were analyzed by the 2-tailed Fisher's exact test and the chi-square test. RESULTS: Sixty-six patients, who had 68 cases of microcalcifications, were enrolled. Thirteen of the 66 patients underwent surgery, and 9 of the 13 were found to have breast carcinoma. In the sonographic re-evaluation before SCNB in these 9 patients, an associated soft tissue mass was demonstrated in 5 patients but not in the other 4. Sonographic re-evaluation also revealed abnormalities in 24 of 68 cases (35.3%), in contrast to the negative findings on the initial sonography. Using the chi-square test to identify a trend, we found that the percentage of cases that were sonographically visible was highest for clustered benign microcalcifications and lowest for segmental benign microcalcifications (p < 0.0001). CONCLUSIONS: In breast lesions that appear as microcalcifications without an associated mass on mammograms, pre-SCNB sonographic re-evaluation with a high-frequency transducer can depict microcalcifications, particularly the clustered ones, and can detect small associated masses. Although the absence of a sonographically detectable mass in areas of mammographically detected microcalcifications does not guarantee the absence of cancer, the presence of an associated mass on sonography should warrant close follow-up in the case of negative results to avoid a delay in the diagnosis of breast carcinoma. SN - 0091-2751 UR - https://www.unboundmedicine.com/medline/citation/12116093/Sonographic_evaluation_of_mammographically_detected_microcalcifications_without_a_mass_prior_to_stereotactic_core_needle_biopsy_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0091-2751&amp;date=2002&amp;volume=30&amp;issue=6&amp;spage=323 DB - PRIME DP - Unbound Medicine ER -