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Hyperhydration induced by glycerol ingestion: hormonal and renal responses.
Can J Physiol Pharmacol. 2002 Jun; 80(6):526-32.CJ

Abstract

The simultaneous time courses of hydromineral hormones (renin-aldosterone system, arginine vasopressin, and atrial natriuretic peptide) and renal responses were examined during and after the completion of hyperhydration induced by glycerol and fluid ingestion. Eight healthy young male Caucasian subjects participated in two separate trials, each including three consecutive phases in a thermoneutral environment. Phases 1 and 3 involved a 90-min period at rest, while phase 2 involved a 120-min period at rest designed to provide either (i) euhydration (control trial) or (ii) hyperhydration induced by ingestion of glycerol (1.1 g/kg body mass) and fluid (21.4 mL/kg body mass). During the 2-h time period of glycerol and fluid ingestion, urine flow, urine osmolality, and plasma levels of hydromineral hormones remained at basal values. In contrast, after hyperhydration completion during phase 3, the diuresis increased markedly together with a dilution of the urine (p < 0.05) while hormonal responses did not change. These results indicate significant differences in renal responses during and after hyperhydration completion and suggest that these changes are independent of fluid-regulating hormonal responses.

Authors+Show Affiliations

Département des Facteurs Humains, Centre de Recherches du Service de Santé des Armées, Emile Pardé, La Tronche, France. brunomelin@crssa.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

12117301

Citation

Melin, Bruno, et al. "Hyperhydration Induced By Glycerol Ingestion: Hormonal and Renal Responses." Canadian Journal of Physiology and Pharmacology, vol. 80, no. 6, 2002, pp. 526-32.
Melin B, Jimenez C, Koulmann N, et al. Hyperhydration induced by glycerol ingestion: hormonal and renal responses. Can J Physiol Pharmacol. 2002;80(6):526-32.
Melin, B., Jimenez, C., Koulmann, N., Allevard, A. M., & Gharib, C. (2002). Hyperhydration induced by glycerol ingestion: hormonal and renal responses. Canadian Journal of Physiology and Pharmacology, 80(6), 526-32.
Melin B, et al. Hyperhydration Induced By Glycerol Ingestion: Hormonal and Renal Responses. Can J Physiol Pharmacol. 2002;80(6):526-32. PubMed PMID: 12117301.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hyperhydration induced by glycerol ingestion: hormonal and renal responses. AU - Melin,Bruno, AU - Jimenez,Chantal, AU - Koulmann,Nathalie, AU - Allevard,Anne-Marie, AU - Gharib,Claude, PY - 2002/7/16/pubmed PY - 2002/12/27/medline PY - 2002/7/16/entrez SP - 526 EP - 32 JF - Canadian journal of physiology and pharmacology JO - Can. J. Physiol. Pharmacol. VL - 80 IS - 6 N2 - The simultaneous time courses of hydromineral hormones (renin-aldosterone system, arginine vasopressin, and atrial natriuretic peptide) and renal responses were examined during and after the completion of hyperhydration induced by glycerol and fluid ingestion. Eight healthy young male Caucasian subjects participated in two separate trials, each including three consecutive phases in a thermoneutral environment. Phases 1 and 3 involved a 90-min period at rest, while phase 2 involved a 120-min period at rest designed to provide either (i) euhydration (control trial) or (ii) hyperhydration induced by ingestion of glycerol (1.1 g/kg body mass) and fluid (21.4 mL/kg body mass). During the 2-h time period of glycerol and fluid ingestion, urine flow, urine osmolality, and plasma levels of hydromineral hormones remained at basal values. In contrast, after hyperhydration completion during phase 3, the diuresis increased markedly together with a dilution of the urine (p < 0.05) while hormonal responses did not change. These results indicate significant differences in renal responses during and after hyperhydration completion and suggest that these changes are independent of fluid-regulating hormonal responses. SN - 0008-4212 UR - https://www.unboundmedicine.com/medline/citation/12117301/Hyperhydration_induced_by_glycerol_ingestion:_hormonal_and_renal_responses_ L2 - http://www.nrcresearchpress.com/doi/full/10.1139/y02-080?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -