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Survivin expression and its correlation with cell proliferation and prognosis in epithelial ovarian tumors.
Int J Oncol. 2002 Aug; 21(2):315-20.IJ

Abstract

Survivin is a new member of the inhibitors of apoptosis proteins (IAP) family, selectively overexpressed in common human cancers but not in normal adult tissues, and associated with aggressiveness of the disease and unfavorable outcomes. Recent study also found that survivin expression is associated with cell proliferation. In order to gain insight into the role of survivin in ovarian tumors, we investigated the expression of survivin in a group of epithelial ovarian tumors, and examined the relationship of its expression with cell proliferation and clinical outcome. Immunohistochemical analysis was performed in 103 cases of epithelial ovarian tumors. Twenty-six of the 103 cases were evaluated by Western blot analysis. The results showed that survivin overexpression was detected in 21.2% (7 of 33) of benign tumors, 47.8% (11 of 23) of borderline tumors, and 51.1% (24 of 47) of ovarian carcinomas. The positive ratio was significantly higher in malignant or borderline tumors than in benign tumors, and the overexpression of survivin was significantly correlated with the size of residual disease. A positive correlation between survivin expression and proliferative activity of tumor cell measured by PCNA index was found. Kaplan-Meier analysis demonstrated that the patients with survivin overexpression have a short overall survival. These findings suggest that survivin overexpression may play a pivotal role in the progression of ovarian tumors and may provide an important prognostic implication for epithelial ovarian carcinomas.

Authors+Show Affiliations

Department of Physiology, Kagawa Medical University, Kagawa, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12118327

Citation

Sui, Li, et al. "Survivin Expression and Its Correlation With Cell Proliferation and Prognosis in Epithelial Ovarian Tumors." International Journal of Oncology, vol. 21, no. 2, 2002, pp. 315-20.
Sui L, Dong Y, Ohno M, et al. Survivin expression and its correlation with cell proliferation and prognosis in epithelial ovarian tumors. Int J Oncol. 2002;21(2):315-20.
Sui, L., Dong, Y., Ohno, M., Watanabe, Y., Sugimoto, K., & Tokuda, M. (2002). Survivin expression and its correlation with cell proliferation and prognosis in epithelial ovarian tumors. International Journal of Oncology, 21(2), 315-20.
Sui L, et al. Survivin Expression and Its Correlation With Cell Proliferation and Prognosis in Epithelial Ovarian Tumors. Int J Oncol. 2002;21(2):315-20. PubMed PMID: 12118327.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Survivin expression and its correlation with cell proliferation and prognosis in epithelial ovarian tumors. AU - Sui,Li, AU - Dong,Youyi, AU - Ohno,Masayuki, AU - Watanabe,Yasuo, AU - Sugimoto,Katsuyoshi, AU - Tokuda,Masaaki, PY - 2002/7/16/pubmed PY - 2003/1/28/medline PY - 2002/7/16/entrez SP - 315 EP - 20 JF - International journal of oncology JO - Int J Oncol VL - 21 IS - 2 N2 - Survivin is a new member of the inhibitors of apoptosis proteins (IAP) family, selectively overexpressed in common human cancers but not in normal adult tissues, and associated with aggressiveness of the disease and unfavorable outcomes. Recent study also found that survivin expression is associated with cell proliferation. In order to gain insight into the role of survivin in ovarian tumors, we investigated the expression of survivin in a group of epithelial ovarian tumors, and examined the relationship of its expression with cell proliferation and clinical outcome. Immunohistochemical analysis was performed in 103 cases of epithelial ovarian tumors. Twenty-six of the 103 cases were evaluated by Western blot analysis. The results showed that survivin overexpression was detected in 21.2% (7 of 33) of benign tumors, 47.8% (11 of 23) of borderline tumors, and 51.1% (24 of 47) of ovarian carcinomas. The positive ratio was significantly higher in malignant or borderline tumors than in benign tumors, and the overexpression of survivin was significantly correlated with the size of residual disease. A positive correlation between survivin expression and proliferative activity of tumor cell measured by PCNA index was found. Kaplan-Meier analysis demonstrated that the patients with survivin overexpression have a short overall survival. These findings suggest that survivin overexpression may play a pivotal role in the progression of ovarian tumors and may provide an important prognostic implication for epithelial ovarian carcinomas. SN - 1019-6439 UR - https://www.unboundmedicine.com/medline/citation/12118327/Survivin_expression_and_its_correlation_with_cell_proliferation_and_prognosis_in_epithelial_ovarian_tumors_ L2 - http://www.spandidos-publications.com/ijo/21/2/315 DB - PRIME DP - Unbound Medicine ER -