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The effects of cholesterol levels on hemorheological parameters in diabetic patients.
Clin Hemorheol Microcirc. 2002; 26(4):257-63.CH

Abstract

Red blood cell (RBC) deformability is an important hemorheological parameter to determine the passage of RBC through narrow capillaries and the reduction of blood viscosity under high shear rates. Although it has been substantial evidence that diabetes mellitus (DM) and hypercholesterolemia increase the risk of coronary heart disease, the mechanism is unclear. In this study the relationship between hemorheological parameters and plasma cholesterol in type 2 diabetic patients (n=55, mean age 43.4+/-9.2 years) was examined. Type 2 diabetic patients were classified as normocholesterolemic (n=25; cholesterol < or = 200 mg/dl) and hypercholesteroloemic (n=30; cholesterol > 200 mg/dl) subgroups. Hypercholesterolemic type 2 diabetic patients had the highest blood and plasma viscosity and the lowest RBC deformability. The results were significantly different from normocholesterolemic type 2 diabetic patients (p<0.001). Our data suggest that elevated plasma cholesterol may impair RBC deformability and increase in blood and plasma viscosity by an additional effect to hyperglycemia in type 2 diabetic patients.

Authors+Show Affiliations

Department of Biophysics, University of Istanbul, Cerrahpasa Medical Faculty, Istanbul, Turkey. melat65@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12122231

Citation

Ercan, Meltem, et al. "The Effects of Cholesterol Levels On Hemorheological Parameters in Diabetic Patients." Clinical Hemorheology and Microcirculation, vol. 26, no. 4, 2002, pp. 257-63.
Ercan M, Konukoğlu D, Erdem T, et al. The effects of cholesterol levels on hemorheological parameters in diabetic patients. Clin Hemorheol Microcirc. 2002;26(4):257-63.
Ercan, M., Konukoğlu, D., Erdem, T., & Onen, S. (2002). The effects of cholesterol levels on hemorheological parameters in diabetic patients. Clinical Hemorheology and Microcirculation, 26(4), 257-63.
Ercan M, et al. The Effects of Cholesterol Levels On Hemorheological Parameters in Diabetic Patients. Clin Hemorheol Microcirc. 2002;26(4):257-63. PubMed PMID: 12122231.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of cholesterol levels on hemorheological parameters in diabetic patients. AU - Ercan,Meltem, AU - Konukoğlu,Dildar, AU - Erdem,Tijen, AU - Onen,Sinan, PY - 2002/7/18/pubmed PY - 2003/7/12/medline PY - 2002/7/18/entrez SP - 257 EP - 63 JF - Clinical hemorheology and microcirculation JO - Clin. Hemorheol. Microcirc. VL - 26 IS - 4 N2 - Red blood cell (RBC) deformability is an important hemorheological parameter to determine the passage of RBC through narrow capillaries and the reduction of blood viscosity under high shear rates. Although it has been substantial evidence that diabetes mellitus (DM) and hypercholesterolemia increase the risk of coronary heart disease, the mechanism is unclear. In this study the relationship between hemorheological parameters and plasma cholesterol in type 2 diabetic patients (n=55, mean age 43.4+/-9.2 years) was examined. Type 2 diabetic patients were classified as normocholesterolemic (n=25; cholesterol < or = 200 mg/dl) and hypercholesteroloemic (n=30; cholesterol > 200 mg/dl) subgroups. Hypercholesterolemic type 2 diabetic patients had the highest blood and plasma viscosity and the lowest RBC deformability. The results were significantly different from normocholesterolemic type 2 diabetic patients (p<0.001). Our data suggest that elevated plasma cholesterol may impair RBC deformability and increase in blood and plasma viscosity by an additional effect to hyperglycemia in type 2 diabetic patients. SN - 1386-0291 UR - https://www.unboundmedicine.com/medline/citation/12122231/The_effects_of_cholesterol_levels_on_hemorheological_parameters_in_diabetic_patients_ L2 - https://content.iospress.com/openurl?genre=article&amp;issn=1386-0291&amp;volume=26&amp;issue=4&amp;spage=257 DB - PRIME DP - Unbound Medicine ER -