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Assessment of three levels of folic acid on serum folate and plasma homocysteine: a randomised placebo-controlled double-blind dietary intervention trial.
Eur J Clin Nutr 2002; 56(8):748-54EJ

Abstract

OBJECTIVE

To determine the minimum effective dose of folic acid required to appreciably increase serum folate and to produce a significant reduction in plasma total homocysteine (tHcy).

DESIGN

Double-blind, randomised placebo-controlled intervention trial.

SETTING

Community-based project in a New Zealand city.

SUBJECTS

Seventy free living men and women with tHcy> or =10 micromol/l. Mean age (range) was 58 (29-90) y.

INTERVENTIONS

Daily consumption over 4 weeks of 20 g breakfast cereal either unfortified (placebo) or fortified with 100, 200 or 300 microg folic acid. Dietary intake was determined by weighed diet records and consumption of commercially fortified products was avoided.

MAIN OUTCOME MEASURES

Plasma tHcy and serum folate concentrations.

RESULTS

Average serum folate concentrations (95% CI) increased significantly in the treatment groups relative to the control group by 28(9-51)%, 60(37-87)% and 79(51-114)% for supplementation with 100, 200 and 300 microg folic acid, respectively. A reduction in tHcy was observed, being 16(8-22)%, 12(4-18)% and 17(9-24)% in the three treatment groups, respectively.

CONCLUSIONS

A regular intake of as little as 100 microg folic acid per day was sufficient to lower tHcy in persons at the upper end of the normal range for tHcy. Low-level fortification may also be appropriate for lowering the risk of neural tube defects given that, when aggregated from all sources, the total intake of folic acid may be sufficiently high to adequately improve the folate status of young women.

Authors+Show Affiliations

Department of Human Nutrition, University of Otago, Dunedin, New Zealand.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12122551

Citation

Venn, B J., et al. "Assessment of Three Levels of Folic Acid On Serum Folate and Plasma Homocysteine: a Randomised Placebo-controlled Double-blind Dietary Intervention Trial." European Journal of Clinical Nutrition, vol. 56, no. 8, 2002, pp. 748-54.
Venn BJ, Mann JI, Williams SM, et al. Assessment of three levels of folic acid on serum folate and plasma homocysteine: a randomised placebo-controlled double-blind dietary intervention trial. Eur J Clin Nutr. 2002;56(8):748-54.
Venn, B. J., Mann, J. I., Williams, S. M., Riddell, L. J., Chisholm, A., Harper, M. J., ... Rossaak, J. I. (2002). Assessment of three levels of folic acid on serum folate and plasma homocysteine: a randomised placebo-controlled double-blind dietary intervention trial. European Journal of Clinical Nutrition, 56(8), pp. 748-54.
Venn BJ, et al. Assessment of Three Levels of Folic Acid On Serum Folate and Plasma Homocysteine: a Randomised Placebo-controlled Double-blind Dietary Intervention Trial. Eur J Clin Nutr. 2002;56(8):748-54. PubMed PMID: 12122551.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Assessment of three levels of folic acid on serum folate and plasma homocysteine: a randomised placebo-controlled double-blind dietary intervention trial. AU - Venn,B J, AU - Mann,J I, AU - Williams,S M, AU - Riddell,L J, AU - Chisholm,A, AU - Harper,M J, AU - Aitken,W, AU - Rossaak,J I, PY - 2001/05/18/received PY - 2001/11/05/revised PY - 2001/11/12/accepted PY - 2002/7/18/pubmed PY - 2002/11/26/medline PY - 2002/7/18/entrez SP - 748 EP - 54 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 56 IS - 8 N2 - OBJECTIVE: To determine the minimum effective dose of folic acid required to appreciably increase serum folate and to produce a significant reduction in plasma total homocysteine (tHcy). DESIGN: Double-blind, randomised placebo-controlled intervention trial. SETTING: Community-based project in a New Zealand city. SUBJECTS: Seventy free living men and women with tHcy> or =10 micromol/l. Mean age (range) was 58 (29-90) y. INTERVENTIONS: Daily consumption over 4 weeks of 20 g breakfast cereal either unfortified (placebo) or fortified with 100, 200 or 300 microg folic acid. Dietary intake was determined by weighed diet records and consumption of commercially fortified products was avoided. MAIN OUTCOME MEASURES: Plasma tHcy and serum folate concentrations. RESULTS: Average serum folate concentrations (95% CI) increased significantly in the treatment groups relative to the control group by 28(9-51)%, 60(37-87)% and 79(51-114)% for supplementation with 100, 200 and 300 microg folic acid, respectively. A reduction in tHcy was observed, being 16(8-22)%, 12(4-18)% and 17(9-24)% in the three treatment groups, respectively. CONCLUSIONS: A regular intake of as little as 100 microg folic acid per day was sufficient to lower tHcy in persons at the upper end of the normal range for tHcy. Low-level fortification may also be appropriate for lowering the risk of neural tube defects given that, when aggregated from all sources, the total intake of folic acid may be sufficiently high to adequately improve the folate status of young women. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/12122551/Assessment_of_three_levels_of_folic_acid_on_serum_folate_and_plasma_homocysteine:_a_randomised_placebo_controlled_double_blind_dietary_intervention_trial_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1601388 DB - PRIME DP - Unbound Medicine ER -