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Functional expression of AMPA receptors on central terminals of rat dorsal root ganglion neurons and presynaptic inhibition of glutamate release.
Neuron. 2002 Jul 03; 35(1):135-46.N

Abstract

No direct evidence has been found for expression of functional AMPA receptors by dorsal root ganglion neurons despite immunocytochemical evidence suggesting they are present. Here we report evidence for expression of functional AMPA receptors by a subpopulation of dorsal root ganglion neurons. The AMPA receptors are most prominently located near central terminals of primary afferent fibers. AMPA and kainate receptors were detected by recording receptor-mediated depolarization of the central terminals under selective pharmacological conditions. We demonstrate that activation of presynaptic AMPA receptors by exogenous agonists causes inhibition of glutamate release from the terminals, possibly via primary afferent depolarization (PAD). These results challenge the traditional view that GABA and GABA(A) receptors exclusively mediate PAD, and indicate that PAD is also mediated by glutamate acting on presynaptically localized AMPA and kainate receptors.

Authors+Show Affiliations

Department of Physiology and Cellular Biophysics, Columbia University, New York, New York 10032, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12123614

Citation

Lee, C Justin, et al. "Functional Expression of AMPA Receptors On Central Terminals of Rat Dorsal Root Ganglion Neurons and Presynaptic Inhibition of Glutamate Release." Neuron, vol. 35, no. 1, 2002, pp. 135-46.
Lee CJ, Bardoni R, Tong CK, et al. Functional expression of AMPA receptors on central terminals of rat dorsal root ganglion neurons and presynaptic inhibition of glutamate release. Neuron. 2002;35(1):135-46.
Lee, C. J., Bardoni, R., Tong, C. K., Engelman, H. S., Joseph, D. J., Magherini, P. C., & MacDermott, A. B. (2002). Functional expression of AMPA receptors on central terminals of rat dorsal root ganglion neurons and presynaptic inhibition of glutamate release. Neuron, 35(1), 135-46.
Lee CJ, et al. Functional Expression of AMPA Receptors On Central Terminals of Rat Dorsal Root Ganglion Neurons and Presynaptic Inhibition of Glutamate Release. Neuron. 2002 Jul 3;35(1):135-46. PubMed PMID: 12123614.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Functional expression of AMPA receptors on central terminals of rat dorsal root ganglion neurons and presynaptic inhibition of glutamate release. AU - Lee,C Justin, AU - Bardoni,Rita, AU - Tong,Chi Kun, AU - Engelman,Holly Sue, AU - Joseph,Donald J, AU - Magherini,Pier Cosimo, AU - MacDermott,Amy B, PY - 2002/7/19/pubmed PY - 2002/8/14/medline PY - 2002/7/19/entrez SP - 135 EP - 46 JF - Neuron JO - Neuron VL - 35 IS - 1 N2 - No direct evidence has been found for expression of functional AMPA receptors by dorsal root ganglion neurons despite immunocytochemical evidence suggesting they are present. Here we report evidence for expression of functional AMPA receptors by a subpopulation of dorsal root ganglion neurons. The AMPA receptors are most prominently located near central terminals of primary afferent fibers. AMPA and kainate receptors were detected by recording receptor-mediated depolarization of the central terminals under selective pharmacological conditions. We demonstrate that activation of presynaptic AMPA receptors by exogenous agonists causes inhibition of glutamate release from the terminals, possibly via primary afferent depolarization (PAD). These results challenge the traditional view that GABA and GABA(A) receptors exclusively mediate PAD, and indicate that PAD is also mediated by glutamate acting on presynaptically localized AMPA and kainate receptors. SN - 0896-6273 UR - https://www.unboundmedicine.com/medline/citation/12123614/Functional_expression_of_AMPA_receptors_on_central_terminals_of_rat_dorsal_root_ganglion_neurons_and_presynaptic_inhibition_of_glutamate_release_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0896627302007298 DB - PRIME DP - Unbound Medicine ER -