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Iodine and gliadin challenge on oral mucosa in dermatitis herpetiformis.
Acta Derm Venereol. 2002; 82(2):86-9.AD

Abstract

Oral lesions and mucosal inflammatory changes may appear in dermatitis herpetiformis (DH). We examined whether potassium iodine, known to initiate blisters in the DH skin, or wheat gliadin, responsible for T-cell-dependent intestinal damage, can induce visible or microscopic changes in oral mucosa. Six patients with active DH were challenged with crude gliadin and 50% potassium iodine applied in patch test chambers on buccal mucosa for 12 h. After reading, biopsies were taken from the challenged and non-challenged mucosa. No macroscopic or microscopic vesicles were seen. However, gliadin- but not iodine-challenged epithelium showed increased numbers of CD4+ lymphocytes in all 5 patients with representative specimens (p = 0.06). No marked changes were found in the numbers of CD8+ or TcR alpha/beta+ lymphocytes, and the numbers of TcR gamma/delta+ cells remained at a low level. The results show that oral mucosa is resistant to production of macroscopic or microscopic DH lesions. It is, however, capable of reacting to locally applied gliadin by a T-cell response consisting of CD4+ lymphocytes.

Authors+Show Affiliations

Department of Oral Surgery, Institute of Dentistry, University of Helsinki, Tampere, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12125958

Citation

Patinen, P, et al. "Iodine and Gliadin Challenge On Oral Mucosa in Dermatitis Herpetiformis." Acta Dermato-venereologica, vol. 82, no. 2, 2002, pp. 86-9.
Patinen P, Hietane J, Malmström M, et al. Iodine and gliadin challenge on oral mucosa in dermatitis herpetiformis. Acta Derm Venereol. 2002;82(2):86-9.
Patinen, P., Hietane, J., Malmström, M., Reunala, T., & Savilahti, E. (2002). Iodine and gliadin challenge on oral mucosa in dermatitis herpetiformis. Acta Dermato-venereologica, 82(2), 86-9.
Patinen P, et al. Iodine and Gliadin Challenge On Oral Mucosa in Dermatitis Herpetiformis. Acta Derm Venereol. 2002;82(2):86-9. PubMed PMID: 12125958.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Iodine and gliadin challenge on oral mucosa in dermatitis herpetiformis. AU - Patinen,P, AU - Hietane,J, AU - Malmström,M, AU - Reunala,T, AU - Savilahti,E, PY - 2002/7/20/pubmed PY - 2002/12/20/medline PY - 2002/7/20/entrez SP - 86 EP - 9 JF - Acta dermato-venereologica JO - Acta Derm Venereol VL - 82 IS - 2 N2 - Oral lesions and mucosal inflammatory changes may appear in dermatitis herpetiformis (DH). We examined whether potassium iodine, known to initiate blisters in the DH skin, or wheat gliadin, responsible for T-cell-dependent intestinal damage, can induce visible or microscopic changes in oral mucosa. Six patients with active DH were challenged with crude gliadin and 50% potassium iodine applied in patch test chambers on buccal mucosa for 12 h. After reading, biopsies were taken from the challenged and non-challenged mucosa. No macroscopic or microscopic vesicles were seen. However, gliadin- but not iodine-challenged epithelium showed increased numbers of CD4+ lymphocytes in all 5 patients with representative specimens (p = 0.06). No marked changes were found in the numbers of CD8+ or TcR alpha/beta+ lymphocytes, and the numbers of TcR gamma/delta+ cells remained at a low level. The results show that oral mucosa is resistant to production of macroscopic or microscopic DH lesions. It is, however, capable of reacting to locally applied gliadin by a T-cell response consisting of CD4+ lymphocytes. SN - 0001-5555 UR - https://www.unboundmedicine.com/medline/citation/12125958/Iodine_and_gliadin_challenge_on_oral_mucosa_in_dermatitis_herpetiformis_ L2 - https://www.medicaljournals.se/acta/content/abstract/10.1080/00015550252948086 DB - PRIME DP - Unbound Medicine ER -