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Application of gas chromatography-surface ionization organic mass spectrometry to forensic toxicology.

Abstract

Surface ionization (SI), which consists in the formation of positive and negative ions along the course of thermal desorption of particles from a solid surface, was first applied as a detector for gas chromatography (GC), GC-surface ionization detection (SID); we developed many new sensitive methods for the determination of abused and other drugs by GC-SID. Recently, Fujii has devised a combination of SI and a quadrupole mass spectrometer and named this system a surface ionization organic mass spectrometer (SIOMS), which is highly selective and sensitive for organic compounds containing tertiary amino groups. We have tried to apply this mass spectrometer to forensic toxicological study; so far we have succeeded in determining important drugs-of-abuse and toxic compounds, such as phencyclidine (PCP), pethidine, pentazocine, MPTP and its derivatives from human body fluids with high sensitivity and selectivity. In this review, we describe our recent studies on the application of GC-SIOMS to forensic toxicology.

Authors+Show Affiliations

Department of Legal Medicine and Bioethics, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya 466-8550, Japan. akishii@fugita-hu.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

12127320

Citation

Ishii, Akira, et al. "Application of Gas Chromatography-surface Ionization Organic Mass Spectrometry to Forensic Toxicology." Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, vol. 776, no. 1, 2002, pp. 3-14.
Ishii A, Watanabe-Suzuki K, Seno H, et al. Application of gas chromatography-surface ionization organic mass spectrometry to forensic toxicology. J Chromatogr B Analyt Technol Biomed Life Sci. 2002;776(1):3-14.
Ishii, A., Watanabe-Suzuki, K., Seno, H., Suzuki, O., & Katsumata, Y. (2002). Application of gas chromatography-surface ionization organic mass spectrometry to forensic toxicology. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 776(1), 3-14.
Ishii A, et al. Application of Gas Chromatography-surface Ionization Organic Mass Spectrometry to Forensic Toxicology. J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Aug 25;776(1):3-14. PubMed PMID: 12127320.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Application of gas chromatography-surface ionization organic mass spectrometry to forensic toxicology. AU - Ishii,Akira, AU - Watanabe-Suzuki,Kanako, AU - Seno,Hiroshi, AU - Suzuki,Osamu, AU - Katsumata,Yoshinao, PY - 2002/7/20/pubmed PY - 2002/10/3/medline PY - 2002/7/20/entrez SP - 3 EP - 14 JF - Journal of chromatography. B, Analytical technologies in the biomedical and life sciences JO - J Chromatogr B Analyt Technol Biomed Life Sci VL - 776 IS - 1 N2 - Surface ionization (SI), which consists in the formation of positive and negative ions along the course of thermal desorption of particles from a solid surface, was first applied as a detector for gas chromatography (GC), GC-surface ionization detection (SID); we developed many new sensitive methods for the determination of abused and other drugs by GC-SID. Recently, Fujii has devised a combination of SI and a quadrupole mass spectrometer and named this system a surface ionization organic mass spectrometer (SIOMS), which is highly selective and sensitive for organic compounds containing tertiary amino groups. We have tried to apply this mass spectrometer to forensic toxicological study; so far we have succeeded in determining important drugs-of-abuse and toxic compounds, such as phencyclidine (PCP), pethidine, pentazocine, MPTP and its derivatives from human body fluids with high sensitivity and selectivity. In this review, we describe our recent studies on the application of GC-SIOMS to forensic toxicology. SN - 1570-0232 UR - https://www.unboundmedicine.com/medline/citation/12127320/Application_of_gas_chromatography_surface_ionization_organic_mass_spectrometry_to_forensic_toxicology_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1570023202001836 DB - PRIME DP - Unbound Medicine ER -