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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics.
Science. 2002 Jul 19; 297(5580):353-6.Sci

Abstract

It has been more than 10 years since it was first proposed that the neurodegeneration in Alzheimer's disease (AD) may be caused by deposition of amyloid beta-peptide (Abeta) in plaques in brain tissue. According to the amyloid hypothesis, accumulation of Abeta in the brain is the primary influence driving AD pathogenesis. The rest of the disease process, including formation of neurofibrillary tangles containing tau protein, is proposed to result from an imbalance between Abeta production and Abeta clearance.

Authors+Show Affiliations

Hardy J
Laboratories of Neurogenetics, National Institute on Aging, Bethesda, MD 20892, USA.
Selkoe DJ
No affiliation info available

MeSH

Alzheimer DiseaseAmino Acid SequenceAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAnimalsAnti-Inflammatory AgentsAnticholesteremic AgentsBrainClinical Trials as TopicHumansMolecular Sequence DataNerve DegenerationNeurofibrillary TanglesNeuronsPlaque, AmyloidProtease Inhibitorstau Proteins

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

12130773

Clinical Trial Links

Assess 123-I IMPY and SPECT Imaging as a Tool to Detect β-Amyloid in the Brain
Blood Brain Barrier Opening in Alzheimer' Disease

Citation

Hardy, John, and Dennis J. Selkoe. "The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems On the Road to Therapeutics." Science (New York, N.Y.), vol. 297, no. 5580, 2002, pp. 353-6.
Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science. 2002;297(5580):353-6.
Hardy, J., & Selkoe, D. J. (2002). The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science (New York, N.Y.), 297(5580), 353-6.
Hardy J, Selkoe DJ. The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems On the Road to Therapeutics. Science. 2002 Jul 19;297(5580):353-6. PubMed PMID: 12130773.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. AU - Hardy,John, AU - Selkoe,Dennis J, PY - 2002/7/20/pubmed PY - 2002/8/13/medline PY - 2002/7/20/entrez SP - 353 EP - 6 JF - Science (New York, N.Y.) JO - Science VL - 297 IS - 5580 N2 - It has been more than 10 years since it was first proposed that the neurodegeneration in Alzheimer's disease (AD) may be caused by deposition of amyloid beta-peptide (Abeta) in plaques in brain tissue. According to the amyloid hypothesis, accumulation of Abeta in the brain is the primary influence driving AD pathogenesis. The rest of the disease process, including formation of neurofibrillary tangles containing tau protein, is proposed to result from an imbalance between Abeta production and Abeta clearance. SN - 1095-9203 UR - https://www.unboundmedicine.com/medline/citation/12130773/The_amyloid_hypothesis_of_Alzheimer's_disease:_progress_and_problems_on_the_road_to_therapeutics_ DB - PRIME DP - Unbound Medicine ER -