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Antiproliferative constituents in plants 9. Aerial parts of Lippia dulcis and Lippia canescens.
Biol Pharm Bull. 2002 Jul; 25(7):920-2.BP

Abstract

The antiproliferative constituents in the MeOH extracts of the aerial parts of Lippia dulcis Trev. and Lippia canescens Kunth (Verbenaceae) were investigated. Activity-guided chemical investigation of the MeOH extracts resulted in the isolation of the three bisabolane-type sesquiterpenes [(+)-hernandulcin (1), (-)-epihernandulcin (2), and (+)-anymol (3)] and four phenylethanoid glycosides [acteoside (4), isoacteoside (5), martynoside (6), and a new diacetylmartynoside (7)] from the former, and four phenylethanoid glycosides [acteoside (4), isoacteoside (5), arenarioside (8), and leucosceptoside A (9)] and three flavones [desmethoxycentaureidin (10), eupafolin (11), and 6-hydroxyluteolin (12)] from the latter. Antiproliferative activity of the isolated compounds against murine melanoma (B16F10), human gastric adenocarcinoma (MK-1), and human uterine carcinoma (HeLa) cells was estimated. (+)-Anymol (3), acteoside (4), isoacteoside (5), arenarioside (8), eupafolin (11), and 6-hydroxyluteolin (12) had GI50 values of 10-16 microM against B16F10 cell. Desmethoxycentaureidin (10) and eupafolin (11) showed high inhibitory activity against HeLa cell growth (GI50 9 microM, and 6 microM, respectively).

Authors+Show Affiliations

Faculty of Pharmaceutical Sciences, Fukuoka University, Japan. abefumi@fukuoka-u.ac.jpNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12132670

Citation

Abe, Fumiko, et al. "Antiproliferative Constituents in Plants 9. Aerial Parts of Lippia Dulcis and Lippia Canescens." Biological & Pharmaceutical Bulletin, vol. 25, no. 7, 2002, pp. 920-2.
Abe F, Nagao T, Okabe H. Antiproliferative constituents in plants 9. Aerial parts of Lippia dulcis and Lippia canescens. Biol Pharm Bull. 2002;25(7):920-2.
Abe, F., Nagao, T., & Okabe, H. (2002). Antiproliferative constituents in plants 9. Aerial parts of Lippia dulcis and Lippia canescens. Biological & Pharmaceutical Bulletin, 25(7), 920-2.
Abe F, Nagao T, Okabe H. Antiproliferative Constituents in Plants 9. Aerial Parts of Lippia Dulcis and Lippia Canescens. Biol Pharm Bull. 2002;25(7):920-2. PubMed PMID: 12132670.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antiproliferative constituents in plants 9. Aerial parts of Lippia dulcis and Lippia canescens. AU - Abe,Fumiko, AU - Nagao,Tsuneatsu, AU - Okabe,Hikaru, PY - 2002/7/23/pubmed PY - 2003/1/9/medline PY - 2002/7/23/entrez SP - 920 EP - 2 JF - Biological & pharmaceutical bulletin JO - Biol. Pharm. Bull. VL - 25 IS - 7 N2 - The antiproliferative constituents in the MeOH extracts of the aerial parts of Lippia dulcis Trev. and Lippia canescens Kunth (Verbenaceae) were investigated. Activity-guided chemical investigation of the MeOH extracts resulted in the isolation of the three bisabolane-type sesquiterpenes [(+)-hernandulcin (1), (-)-epihernandulcin (2), and (+)-anymol (3)] and four phenylethanoid glycosides [acteoside (4), isoacteoside (5), martynoside (6), and a new diacetylmartynoside (7)] from the former, and four phenylethanoid glycosides [acteoside (4), isoacteoside (5), arenarioside (8), and leucosceptoside A (9)] and three flavones [desmethoxycentaureidin (10), eupafolin (11), and 6-hydroxyluteolin (12)] from the latter. Antiproliferative activity of the isolated compounds against murine melanoma (B16F10), human gastric adenocarcinoma (MK-1), and human uterine carcinoma (HeLa) cells was estimated. (+)-Anymol (3), acteoside (4), isoacteoside (5), arenarioside (8), eupafolin (11), and 6-hydroxyluteolin (12) had GI50 values of 10-16 microM against B16F10 cell. Desmethoxycentaureidin (10) and eupafolin (11) showed high inhibitory activity against HeLa cell growth (GI50 9 microM, and 6 microM, respectively). SN - 0918-6158 UR - https://www.unboundmedicine.com/medline/citation/12132670/Antiproliferative_constituents_in_plants_9__Aerial_parts_of_Lippia_dulcis_and_Lippia_canescens_ L2 - http://joi.jlc.jst.go.jp/JST.JSTAGE/bpb/25.920?from=PubMed DB - PRIME DP - Unbound Medicine ER -