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An immunocytochemical investigation of human trigeminal nucleus caudalis: CGRP, substance P and 5-HT1D-receptor immunoreactivities are expressed by trigeminal sensory fibres.
Cephalalgia. 2002 Jul; 22(6):424-31.C

Abstract

5-HT1D (but not 5-HT1B)-receptor immunoreactivity (i.r.) can be detected on trigeminal fibres within the spinal trigeminal tract of the human brainstem. The present study used immunohistochemical and morphometric techniques to determine the proportions of trigeminal fibres expressing substance P, CGRP or 5-HT1D-receptor immunoreactivities. Co-localization studies between 5-HT1D-receptor and substance P- or CGRP-i.r. were also performed. Brainstem material was obtained with consent (four donors) and the total number of immunoreactive fibres within the trigeminal tract was estimated using random field sampling. A greater proportion of fibres (>1 microm diameter) expressed CGRP-i.r. (80 +/- 6%) compared with substance P-i.r. (46 +/- 7%) or 5-HT1D-receptor-i.r. (25 +/- 1%). 5-HT1D-receptor-i.r. was co-localized on some CGRP- or substance P-i.r. fibres. This suggests that 5-HT1D-receptors can regulate the release of CGRP and substance P and may be relevant to the clinical effectiveness of 5-HT1B/1D-receptor agonists in the treatment of migraine and other cranial pain syndromes.

Authors+Show Affiliations

Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, UK.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12133041

Citation

Smith, D, et al. "An Immunocytochemical Investigation of Human Trigeminal Nucleus Caudalis: CGRP, Substance P and 5-HT1D-receptor Immunoreactivities Are Expressed By Trigeminal Sensory Fibres." Cephalalgia : an International Journal of Headache, vol. 22, no. 6, 2002, pp. 424-31.
Smith D, Hill RG, Edvinsson L, et al. An immunocytochemical investigation of human trigeminal nucleus caudalis: CGRP, substance P and 5-HT1D-receptor immunoreactivities are expressed by trigeminal sensory fibres. Cephalalgia. 2002;22(6):424-31.
Smith, D., Hill, R. G., Edvinsson, L., & Longmore, J. (2002). An immunocytochemical investigation of human trigeminal nucleus caudalis: CGRP, substance P and 5-HT1D-receptor immunoreactivities are expressed by trigeminal sensory fibres. Cephalalgia : an International Journal of Headache, 22(6), 424-31.
Smith D, et al. An Immunocytochemical Investigation of Human Trigeminal Nucleus Caudalis: CGRP, Substance P and 5-HT1D-receptor Immunoreactivities Are Expressed By Trigeminal Sensory Fibres. Cephalalgia. 2002;22(6):424-31. PubMed PMID: 12133041.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An immunocytochemical investigation of human trigeminal nucleus caudalis: CGRP, substance P and 5-HT1D-receptor immunoreactivities are expressed by trigeminal sensory fibres. AU - Smith,D, AU - Hill,R G, AU - Edvinsson,L, AU - Longmore,J, PY - 2002/7/23/pubmed PY - 2003/1/18/medline PY - 2002/7/23/entrez SP - 424 EP - 31 JF - Cephalalgia : an international journal of headache JO - Cephalalgia VL - 22 IS - 6 N2 - 5-HT1D (but not 5-HT1B)-receptor immunoreactivity (i.r.) can be detected on trigeminal fibres within the spinal trigeminal tract of the human brainstem. The present study used immunohistochemical and morphometric techniques to determine the proportions of trigeminal fibres expressing substance P, CGRP or 5-HT1D-receptor immunoreactivities. Co-localization studies between 5-HT1D-receptor and substance P- or CGRP-i.r. were also performed. Brainstem material was obtained with consent (four donors) and the total number of immunoreactive fibres within the trigeminal tract was estimated using random field sampling. A greater proportion of fibres (>1 microm diameter) expressed CGRP-i.r. (80 +/- 6%) compared with substance P-i.r. (46 +/- 7%) or 5-HT1D-receptor-i.r. (25 +/- 1%). 5-HT1D-receptor-i.r. was co-localized on some CGRP- or substance P-i.r. fibres. This suggests that 5-HT1D-receptors can regulate the release of CGRP and substance P and may be relevant to the clinical effectiveness of 5-HT1B/1D-receptor agonists in the treatment of migraine and other cranial pain syndromes. SN - 0333-1024 UR - https://www.unboundmedicine.com/medline/citation/12133041/An_immunocytochemical_investigation_of_human_trigeminal_nucleus_caudalis:_CGRP_substance_P_and_5_HT1D_receptor_immunoreactivities_are_expressed_by_trigeminal_sensory_fibres_ L2 - http://journals.sagepub.com/doi/full/10.1046/j.1468-2982.2002.00378.x?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -