Tags

Type your tag names separated by a space and hit enter

Risk factors for nephrolithiasis in patients with familial idiopathic hypercalciuria.

Abstract

PURPOSE

About 40% of patients with nephrolithiasis have idiopathic hypercalciuria, sometimes associated with a family history of kidney stones. In these families, little is known about the frequency of, and risk factors for, stone formation among hypercalciuric patients. We therefore conducted a prospective study of 216 subjects from 33 families with idiopathic hypercalciuria.

MATERIALS AND METHODS

We recorded the age, weight, and history of calcium stones in all subjects, and measured 24-hour urine volume and excretion of calcium, uric acid, sodium, magnesium, urea, citrate, phosphate, and sulfate on a nonrestricted diet. We performed a more complete metabolic evaluation in many of the hypercalciuric subjects (calciuria/weight >0.1 mmol/kg/d). Multivariate logistic regression analysis was performed to identify independent risk factors for stone formation.

RESULTS

The prevalence of self-reported nephrolithiasis was 46% (61/132) in hypercalciuric subjects and 11% (7/63) in normocalciuric subjects (P <0.0001). In multivariate analysis, age (odds ratio [OR] per 10 years of age = 1.3; 95% confidence interval [CI]: 1.1 to 1.6), urine calcium excretion (OR = 1.3 per mmol/d increase; 95% CI: 1.2 to 1.5), and uric acid excretion (OR = 3.3 per mmol/d increase; 95% CI: 1.4 to 7.5) were independent risk factors for nephrolithiasis. The risk of nephrolithiasis increased progressively with greater levels of hypercalciuria.

CONCLUSION

We found a significant dose-effect association between calciuria and stone disease in patients with familial hypercalciuria. Other factors associated with stone formation included higher uric acid excretion, probably reflecting higher food intake, and age, probably reflecting the length of exposure to hypercalciuria and hyperuricosuria.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Service de Néphrologie A, Hôpital Tenon, Paris, France.

    , , , , , ,

    Source

    The American journal of medicine 113:2 2002 Aug 01 pg 99-103

    MeSH

    Adult
    Age Distribution
    Aged
    Calcium
    Cohort Studies
    Comorbidity
    Female
    Humans
    Hypercalcemia
    Kidney Calculi
    Male
    Middle Aged
    Multivariate Analysis
    Odds Ratio
    Prevalence
    Probability
    Prospective Studies
    Risk Factors
    Sex Distribution
    Statistics, Nonparametric

    Pub Type(s)

    Comparative Study
    Journal Article

    Language

    eng

    PubMed ID

    12133747

    Citation

    Lerolle, Nicolas, et al. "Risk Factors for Nephrolithiasis in Patients With Familial Idiopathic Hypercalciuria." The American Journal of Medicine, vol. 113, no. 2, 2002, pp. 99-103.
    Lerolle N, Lantz B, Paillard F, et al. Risk factors for nephrolithiasis in patients with familial idiopathic hypercalciuria. Am J Med. 2002;113(2):99-103.
    Lerolle, N., Lantz, B., Paillard, F., Gattegno, B., Flahault, A., Ronco, P., ... Rondeau, E. (2002). Risk factors for nephrolithiasis in patients with familial idiopathic hypercalciuria. The American Journal of Medicine, 113(2), pp. 99-103.
    Lerolle N, et al. Risk Factors for Nephrolithiasis in Patients With Familial Idiopathic Hypercalciuria. Am J Med. 2002 Aug 1;113(2):99-103. PubMed PMID: 12133747.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Risk factors for nephrolithiasis in patients with familial idiopathic hypercalciuria. AU - Lerolle,Nicolas, AU - Lantz,Brigitte, AU - Paillard,Françoise, AU - Gattegno,Bernard, AU - Flahault,Antoine, AU - Ronco,Pierre, AU - Houillier,Pascal, AU - Rondeau,Eric, PY - 2002/7/23/pubmed PY - 2002/8/17/medline PY - 2002/7/23/entrez SP - 99 EP - 103 JF - The American journal of medicine JO - Am. J. Med. VL - 113 IS - 2 N2 - PURPOSE: About 40% of patients with nephrolithiasis have idiopathic hypercalciuria, sometimes associated with a family history of kidney stones. In these families, little is known about the frequency of, and risk factors for, stone formation among hypercalciuric patients. We therefore conducted a prospective study of 216 subjects from 33 families with idiopathic hypercalciuria. MATERIALS AND METHODS: We recorded the age, weight, and history of calcium stones in all subjects, and measured 24-hour urine volume and excretion of calcium, uric acid, sodium, magnesium, urea, citrate, phosphate, and sulfate on a nonrestricted diet. We performed a more complete metabolic evaluation in many of the hypercalciuric subjects (calciuria/weight >0.1 mmol/kg/d). Multivariate logistic regression analysis was performed to identify independent risk factors for stone formation. RESULTS: The prevalence of self-reported nephrolithiasis was 46% (61/132) in hypercalciuric subjects and 11% (7/63) in normocalciuric subjects (P <0.0001). In multivariate analysis, age (odds ratio [OR] per 10 years of age = 1.3; 95% confidence interval [CI]: 1.1 to 1.6), urine calcium excretion (OR = 1.3 per mmol/d increase; 95% CI: 1.2 to 1.5), and uric acid excretion (OR = 3.3 per mmol/d increase; 95% CI: 1.4 to 7.5) were independent risk factors for nephrolithiasis. The risk of nephrolithiasis increased progressively with greater levels of hypercalciuria. CONCLUSION: We found a significant dose-effect association between calciuria and stone disease in patients with familial hypercalciuria. Other factors associated with stone formation included higher uric acid excretion, probably reflecting higher food intake, and age, probably reflecting the length of exposure to hypercalciuria and hyperuricosuria. SN - 0002-9343 UR - https://www.unboundmedicine.com/medline/citation/12133747/Risk_factors_for_nephrolithiasis_in_patients_with_familial_idiopathic_hypercalciuria_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S000293430201152X DB - PRIME DP - Unbound Medicine ER -