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Folate, homocysteine, and neurological function.
Nutr Clin Care 2002 May-Jun; 5(3):124-32NC

Abstract

The study of different neurological problems, including stroke, Alzheimer's disease (AD), and depression, has propelled a greater interest in interrelationships among folate, homocysteine, and neurological function. Specifically, low folate status is a suspected risk factor for depression that also results in an increase in circulating levels of the sulfur amino acid homocysteine. Homocysteine has emerged as an independent risk factor for stroke, and recent studies suggest that vascular disease affecting the brain and Alzheimer's disease may result together in senile dementia. The relationship between stroke and AD was at first interpreted as coincidence, given the pathologic distinctions between the two diseases. However, the connection is now hypothesized to reflect some common pathogenic factors involving folate, homocysteine, or both. It remains unclear whether there is a causal relationship between neurological dysfunction in either condition with folate or homocysteine. Nevertheless, since improvement of folate status lowers homocysteine levels, the hypothesis that folate supplementation may lower the risk of several important health consequences of aging, including various forms of neuropsychiatric dysfunction, is worthy of current intensive exploration.

Authors+Show Affiliations

Nutritional Epidemiology Program, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, 9th Floor, Boston, MA 02111, USA. Morris@HNRC.Tufts.edu

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

12134567

Citation

Morris, Martha Savaria. "Folate, Homocysteine, and Neurological Function." Nutrition in Clinical Care : an Official Publication of Tufts University, vol. 5, no. 3, 2002, pp. 124-32.
Morris MS. Folate, homocysteine, and neurological function. Nutr Clin Care. 2002;5(3):124-32.
Morris, M. S. (2002). Folate, homocysteine, and neurological function. Nutrition in Clinical Care : an Official Publication of Tufts University, 5(3), pp. 124-32.
Morris MS. Folate, Homocysteine, and Neurological Function. Nutr Clin Care. 2002;5(3):124-32. PubMed PMID: 12134567.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Folate, homocysteine, and neurological function. A1 - Morris,Martha Savaria, PY - 2002/7/24/pubmed PY - 2002/10/3/medline PY - 2002/7/24/entrez SP - 124 EP - 32 JF - Nutrition in clinical care : an official publication of Tufts University JO - Nutr Clin Care VL - 5 IS - 3 N2 - The study of different neurological problems, including stroke, Alzheimer's disease (AD), and depression, has propelled a greater interest in interrelationships among folate, homocysteine, and neurological function. Specifically, low folate status is a suspected risk factor for depression that also results in an increase in circulating levels of the sulfur amino acid homocysteine. Homocysteine has emerged as an independent risk factor for stroke, and recent studies suggest that vascular disease affecting the brain and Alzheimer's disease may result together in senile dementia. The relationship between stroke and AD was at first interpreted as coincidence, given the pathologic distinctions between the two diseases. However, the connection is now hypothesized to reflect some common pathogenic factors involving folate, homocysteine, or both. It remains unclear whether there is a causal relationship between neurological dysfunction in either condition with folate or homocysteine. Nevertheless, since improvement of folate status lowers homocysteine levels, the hypothesis that folate supplementation may lower the risk of several important health consequences of aging, including various forms of neuropsychiatric dysfunction, is worthy of current intensive exploration. SN - 1096-6781 UR - https://www.unboundmedicine.com/medline/citation/12134567/Folate_homocysteine_and_neurological_function_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=12134567.ui DB - PRIME DP - Unbound Medicine ER -