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Effect of the interaction between steatosis and alcohol intake on liver fibrosis progression in chronic hepatitis C.
Am J Gastroenterol. 2002 Jul; 97(7):1807-12.AJ

Abstract

OBJECTIVES

Liver steatosis is a common histopathological finding in patients infected with hepatitis C virus. Patients with chronic hepatitis C having both steatosis and factors causing oxidative stress may be at a higher risk of fibrogenesis. In a subset of patients with a definite date of contamination, our study aimed to assess the potential synergistic interaction between steatosis and factors likely to induce oxidative stress-namely, alcohol intake, iron overload, and drugs.

METHODS

Out of 700 anti-HCV-positive screened patients, 142 untreated patients with liver biopsy and with one known risk factor were selected. Liver fibrosis, inflammation, and necrosis were graded according to the Knodell score, and steatosis as moderate to severe if more than 30% of hepatocytes were affected. Drinkers were defined as having daily mean alcohol intakes of more than 30 g in men and 20 g in women.

RESULTS

In multivariate analysis, two factors were independently associated with extensive fibrosis: the degree of severity of piecemeal necrosis (OR = 3.27, CI = 1 .17-9.16) and a combination of moderate to severe steatosis and alcohol intake (OR = 7.02, CI = 1.12-44). The median progression rate of fibrosis was about twice as high among drinkers with steatosis than among drinkers without steatosis or nondrinkers with or without steatosis (0.25 vs 0. I vs 0.13 vs 0.08, respectively; p = 0.02). Independent parameters significantly associated with moderate to severe steatosis were body mass index (OR = 1.13, CI = 1.02-1.26) and infection with genotype 3 (OR = 5.5, CI = 1.88-16), but not alcohol consumption.

CONCLUSIONS

As well as the key role of the severity of piecemeal necrosis, the study underlines the synergistic interaction between steatosis and even low alcohol consumption as a contributory factor in extensive liver fibrosis.

Authors+Show Affiliations

Service d'Hépatologie, Hôpital Saint-Antoine, AP-Hôpitaux de Paris, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12135040

Citation

Serfaty, Lawrence, et al. "Effect of the Interaction Between Steatosis and Alcohol Intake On Liver Fibrosis Progression in Chronic Hepatitis C." The American Journal of Gastroenterology, vol. 97, no. 7, 2002, pp. 1807-12.
Serfaty L, Poujol-Robert A, Carbonell N, et al. Effect of the interaction between steatosis and alcohol intake on liver fibrosis progression in chronic hepatitis C. Am J Gastroenterol. 2002;97(7):1807-12.
Serfaty, L., Poujol-Robert, A., Carbonell, N., Chazouillères, O., Poupon, R. E., & Poupon, R. (2002). Effect of the interaction between steatosis and alcohol intake on liver fibrosis progression in chronic hepatitis C. The American Journal of Gastroenterology, 97(7), 1807-12.
Serfaty L, et al. Effect of the Interaction Between Steatosis and Alcohol Intake On Liver Fibrosis Progression in Chronic Hepatitis C. Am J Gastroenterol. 2002;97(7):1807-12. PubMed PMID: 12135040.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of the interaction between steatosis and alcohol intake on liver fibrosis progression in chronic hepatitis C. AU - Serfaty,Lawrence, AU - Poujol-Robert,Armelle, AU - Carbonell,Nicolas, AU - Chazouillères,Olivier, AU - Poupon,Renée E, AU - Poupon,Raoul, PY - 2002/7/24/pubmed PY - 2002/9/17/medline PY - 2002/7/24/entrez SP - 1807 EP - 12 JF - The American journal of gastroenterology JO - Am J Gastroenterol VL - 97 IS - 7 N2 - OBJECTIVES: Liver steatosis is a common histopathological finding in patients infected with hepatitis C virus. Patients with chronic hepatitis C having both steatosis and factors causing oxidative stress may be at a higher risk of fibrogenesis. In a subset of patients with a definite date of contamination, our study aimed to assess the potential synergistic interaction between steatosis and factors likely to induce oxidative stress-namely, alcohol intake, iron overload, and drugs. METHODS: Out of 700 anti-HCV-positive screened patients, 142 untreated patients with liver biopsy and with one known risk factor were selected. Liver fibrosis, inflammation, and necrosis were graded according to the Knodell score, and steatosis as moderate to severe if more than 30% of hepatocytes were affected. Drinkers were defined as having daily mean alcohol intakes of more than 30 g in men and 20 g in women. RESULTS: In multivariate analysis, two factors were independently associated with extensive fibrosis: the degree of severity of piecemeal necrosis (OR = 3.27, CI = 1 .17-9.16) and a combination of moderate to severe steatosis and alcohol intake (OR = 7.02, CI = 1.12-44). The median progression rate of fibrosis was about twice as high among drinkers with steatosis than among drinkers without steatosis or nondrinkers with or without steatosis (0.25 vs 0. I vs 0.13 vs 0.08, respectively; p = 0.02). Independent parameters significantly associated with moderate to severe steatosis were body mass index (OR = 1.13, CI = 1.02-1.26) and infection with genotype 3 (OR = 5.5, CI = 1.88-16), but not alcohol consumption. CONCLUSIONS: As well as the key role of the severity of piecemeal necrosis, the study underlines the synergistic interaction between steatosis and even low alcohol consumption as a contributory factor in extensive liver fibrosis. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/12135040/Effect_of_the_interaction_between_steatosis_and_alcohol_intake_on_liver_fibrosis_progression_in_chronic_hepatitis_C_ L2 - https://Insights.ovid.com/pubmed?pmid=12135040 DB - PRIME DP - Unbound Medicine ER -