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Antioxidative flavonoids from leaves of Carthamus tinctorius.
Arch Pharm Res. 2002 Jun; 25(3):313-9.AP

Abstract

A total of eight flavonoids (1-8), including a novel quercetin-7-O-(6''-O-acetyl)-beta-D-glucopyranoside (6) and seven known flavonoids, luteolin (1), quercetin (2), luteolin 7-O-beta-D-glucopyranoside (3), luteolin-7-O-(6''-O-acetyl)-beta-D-glucopyranoside (4) quercetin 7-O-beta-D-glucopyranoside (5), acacetin 7-O-beta-D-glucuronide (7) and apigenin-6-C-beta-D-glucopyrano syl-8-C-beta-D-glucopyranoside (8), have been isolated from the leaves of the safflower (Carthamus tinctorius L.) and identified on the basis of spectroscopic and chemical studies. The antioxidative activity of these flavonoids was evaluated against 2-deoxyribose degradation and rat liver microsomal lipid peroxidation induced by hydroxyl radicals generated via a Fenton-type reaction. Among these flavonoids, luteolin-acetyl-glucoside (4) and quercetin-acetyl-glucoside (6) showed potent antioxidative activities against 2-deoxyribose degradation and lipid peroxidation in rat liver microsomes. Luteolin (1), quercetin (2), and their corresponding glycosides (3 & 5) also exhibited strong antioxidative activity, while acacetin glucuronide (7) and apigenin-6,8-di-C-glucoside (8) were relatively less active.

Authors+Show Affiliations

Department of Food Science and Nutrition, Catholic University of Daegu, Hayang, Gyeongbuk, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12135103

Citation

Lee, Jun Young, et al. "Antioxidative Flavonoids From Leaves of Carthamus Tinctorius." Archives of Pharmacal Research, vol. 25, no. 3, 2002, pp. 313-9.
Lee JY, Chang EJ, Kim HJ, et al. Antioxidative flavonoids from leaves of Carthamus tinctorius. Arch Pharm Res. 2002;25(3):313-9.
Lee, J. Y., Chang, E. J., Kim, H. J., Park, J. H., & Choi, S. W. (2002). Antioxidative flavonoids from leaves of Carthamus tinctorius. Archives of Pharmacal Research, 25(3), 313-9.
Lee JY, et al. Antioxidative Flavonoids From Leaves of Carthamus Tinctorius. Arch Pharm Res. 2002;25(3):313-9. PubMed PMID: 12135103.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidative flavonoids from leaves of Carthamus tinctorius. AU - Lee,Jun Young, AU - Chang,Eun Ju, AU - Kim,Hyo Jin, AU - Park,Jun Hong, AU - Choi,Sang Won, PY - 2002/7/24/pubmed PY - 2003/1/8/medline PY - 2002/7/24/entrez SP - 313 EP - 9 JF - Archives of pharmacal research JO - Arch Pharm Res VL - 25 IS - 3 N2 - A total of eight flavonoids (1-8), including a novel quercetin-7-O-(6''-O-acetyl)-beta-D-glucopyranoside (6) and seven known flavonoids, luteolin (1), quercetin (2), luteolin 7-O-beta-D-glucopyranoside (3), luteolin-7-O-(6''-O-acetyl)-beta-D-glucopyranoside (4) quercetin 7-O-beta-D-glucopyranoside (5), acacetin 7-O-beta-D-glucuronide (7) and apigenin-6-C-beta-D-glucopyrano syl-8-C-beta-D-glucopyranoside (8), have been isolated from the leaves of the safflower (Carthamus tinctorius L.) and identified on the basis of spectroscopic and chemical studies. The antioxidative activity of these flavonoids was evaluated against 2-deoxyribose degradation and rat liver microsomal lipid peroxidation induced by hydroxyl radicals generated via a Fenton-type reaction. Among these flavonoids, luteolin-acetyl-glucoside (4) and quercetin-acetyl-glucoside (6) showed potent antioxidative activities against 2-deoxyribose degradation and lipid peroxidation in rat liver microsomes. Luteolin (1), quercetin (2), and their corresponding glycosides (3 & 5) also exhibited strong antioxidative activity, while acacetin glucuronide (7) and apigenin-6,8-di-C-glucoside (8) were relatively less active. SN - 0253-6269 UR - https://www.unboundmedicine.com/medline/citation/12135103/Antioxidative_flavonoids_from_leaves_of_Carthamus_tinctorius_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=12135103.ui DB - PRIME DP - Unbound Medicine ER -