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Differential effects of NMDA and AMPA/KA receptor antagonists on c-Fos or Zif/268 expression in the rat spinal dorsal horn induced by noxious thermal or mechanical stimulation, or formalin injection.
Neurosci Res. 2002 Aug; 43(4):389-99.NR

Abstract

The involvement of N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA)/kainate (KA) receptors in the induction of c-Fos and Zif/268 expression in spinal dorsal horn neurons following noxious thermal or mechanical stimulation, or formalin injection into the rat hind paw was examined by intrathecal administration of a competitive NMDA receptor antagonist, 2-amino-5-phosphonopentanoic acid (APV) or an AMPA/KA receptor antagonist, 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), or both, 30 min prior to noxious stimulation. APV caused a significant reduction in the level of c-Fos expression in the superficial layer induced by each of these three noxious stimuli. The effects of APV on Zif/268 expression or of CNQX on c-Fos or Zif/268 expression in the superficial layer induced by these three noxious stimuli were dependent on the type of stimulus applied to the rat hind paw. The noxious thermal stimulus-evoked c-Fos expression level was reduced by APV and/or CNQX, while Zif/268 expression was hardly changed. Both c-Fos and Zif/268 expressions following formalin injection were reduced by APV alone and APV+CNQX, but not by CNQX alone. Zif/268 expression following noxious mechanical stimulation was significantly reduced only by APV+CNQX although APV or CNQX alone did not affect the expression, while c-Fos expression was reduced by APV and APV+CNQX but not by CNQX alone. These findings suggest that NMDA and AMPA/KA receptors are differentially involved in c-Fos and Zif/268 expression in the spinal dorsal horn following noxious thermal, formalin and mechanical stimulation.

Authors+Show Affiliations

Department of Oral and Maxillofacial Surgery, Miyazaki Medical College, Kiyotake, Miyazaki 889-1692, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12135782

Citation

Rahman, Omar I F., et al. "Differential Effects of NMDA and AMPA/KA Receptor Antagonists On c-Fos or Zif/268 Expression in the Rat Spinal Dorsal Horn Induced By Noxious Thermal or Mechanical Stimulation, or Formalin Injection." Neuroscience Research, vol. 43, no. 4, 2002, pp. 389-99.
Rahman OI, Terayama R, Ikeda T, et al. Differential effects of NMDA and AMPA/KA receptor antagonists on c-Fos or Zif/268 expression in the rat spinal dorsal horn induced by noxious thermal or mechanical stimulation, or formalin injection. Neurosci Res. 2002;43(4):389-99.
Rahman, O. I., Terayama, R., Ikeda, T., Koganemaru, M., Nakamura, T., Shiba, R., & Nishimori, T. (2002). Differential effects of NMDA and AMPA/KA receptor antagonists on c-Fos or Zif/268 expression in the rat spinal dorsal horn induced by noxious thermal or mechanical stimulation, or formalin injection. Neuroscience Research, 43(4), 389-99.
Rahman OI, et al. Differential Effects of NMDA and AMPA/KA Receptor Antagonists On c-Fos or Zif/268 Expression in the Rat Spinal Dorsal Horn Induced By Noxious Thermal or Mechanical Stimulation, or Formalin Injection. Neurosci Res. 2002;43(4):389-99. PubMed PMID: 12135782.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential effects of NMDA and AMPA/KA receptor antagonists on c-Fos or Zif/268 expression in the rat spinal dorsal horn induced by noxious thermal or mechanical stimulation, or formalin injection. AU - Rahman,Omar I F, AU - Terayama,Ryuji, AU - Ikeda,Tetsuya, AU - Koganemaru,Mikako, AU - Nakamura,Tadashi, AU - Shiba,Ryosuke, AU - Nishimori,Toshikazu, PY - 2002/7/24/pubmed PY - 2002/10/11/medline PY - 2002/7/24/entrez SP - 389 EP - 99 JF - Neuroscience research JO - Neurosci Res VL - 43 IS - 4 N2 - The involvement of N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA)/kainate (KA) receptors in the induction of c-Fos and Zif/268 expression in spinal dorsal horn neurons following noxious thermal or mechanical stimulation, or formalin injection into the rat hind paw was examined by intrathecal administration of a competitive NMDA receptor antagonist, 2-amino-5-phosphonopentanoic acid (APV) or an AMPA/KA receptor antagonist, 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), or both, 30 min prior to noxious stimulation. APV caused a significant reduction in the level of c-Fos expression in the superficial layer induced by each of these three noxious stimuli. The effects of APV on Zif/268 expression or of CNQX on c-Fos or Zif/268 expression in the superficial layer induced by these three noxious stimuli were dependent on the type of stimulus applied to the rat hind paw. The noxious thermal stimulus-evoked c-Fos expression level was reduced by APV and/or CNQX, while Zif/268 expression was hardly changed. Both c-Fos and Zif/268 expressions following formalin injection were reduced by APV alone and APV+CNQX, but not by CNQX alone. Zif/268 expression following noxious mechanical stimulation was significantly reduced only by APV+CNQX although APV or CNQX alone did not affect the expression, while c-Fos expression was reduced by APV and APV+CNQX but not by CNQX alone. These findings suggest that NMDA and AMPA/KA receptors are differentially involved in c-Fos and Zif/268 expression in the spinal dorsal horn following noxious thermal, formalin and mechanical stimulation. SN - 0168-0102 UR - https://www.unboundmedicine.com/medline/citation/12135782/Differential_effects_of_NMDA_and_AMPA/KA_receptor_antagonists_on_c_Fos_or_Zif/268_expression_in_the_rat_spinal_dorsal_horn_induced_by_noxious_thermal_or_mechanical_stimulation_or_formalin_injection_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168010202000676 DB - PRIME DP - Unbound Medicine ER -