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Omega-3 fatty acids (from fish oils) for cystic fibrosis.

Abstract

BACKGROUND

Epidemiological (population studies) and other studies suggest that a diet rich in omega-3 essential fatty acids (derived from fish oil) may have beneficial anti-inflammatory effects for chronic conditions such as cystic fibrosis.

OBJECTIVES

To determine whether there is evidence that omega-3 polyunsaturated fatty acid supplementation reduces morbidity and mortality. To identify any adverse events associated with omega-3 polyunsaturated fatty acid supplementation.

SEARCH STRATEGY

We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group specialised trials register, which comprises references identified from comprehensive electronic database searches, handsearching relevant journals and handsearching abstract books of conference proceedings. Authors and persons interested in the question were contacted. Date of the most recent search of the Group's specialised register: May 2002.

SELECTION CRITERIA

Randomised controlled trials in patients with cystic fibrosis in which omega-3 fatty acid supplements were compared with a placebo oil.

DATA COLLECTION AND ANALYSIS

Two reviewers independently selected the trials to be included in the review and assessed the methodological quality of the trials using two approaches: Cochrane assessment of allocation concealment and Jadad quality assessment score. Using data acquisition forms, two reviewers independently extracted data. Missing data has been requested.

MAIN RESULTS

The initial literature search identified six trials. Two trials, involving 31 participants satisfied our inclusion criteria and were included in the review. Both compared omega-3 fatty acids to olive oil controls for a six week treatment period. One study (19 participants) showed an improvement in FEV1, FVC, Shwachman score and reduction in sputum volume in the fish oil group at the end of this short treatment period.

REVIEWER'S CONCLUSIONS

The review of trials found that regular omega-3 supplements may provide some benefits for people with cystic fibrosis with relatively few adverse effects, although the evidence is insufficient to draw firm conclusions. There is insufficient evidence to recommend routine use of supplements of omega-3 fatty acids in people with cystic fibrosis. The most notable feature highlighted by this review was the lack of data for many of the outcomes likely to be meaningful to people with or making treatment decisions about CF. A large, long-term, multi-centre, randomised controlled study is needed in order to determine if there is a significant therapeutic effect and to assess the influence of disease severity, dosage and duration of treatment. Future researchers should note the need for additional pancreatic enzymes.

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  • Authors+Show Affiliations

    ,

    Department of Nutrition and Dietetics, Sheffield Children's Hospital NHS Trust, Western Bank, Sheffield, UK, S10 2TH. naomibw@talk21.com

    ,

    Source

    MeSH

    Cystic Fibrosis
    Dietary Supplements
    Fatty Acids, Omega-3
    Humans
    Randomized Controlled Trials as Topic

    Pub Type(s)

    Journal Article
    Review
    Systematic Review

    Language

    eng

    PubMed ID

    12137649

    Citation

    Beckles Willson, N, et al. "Omega-3 Fatty Acids (from Fish Oils) for Cystic Fibrosis." The Cochrane Database of Systematic Reviews, 2002, p. CD002201.
    Beckles Willson N, Elliott TM, Everard ML. Omega-3 fatty acids (from fish oils) for cystic fibrosis. Cochrane Database Syst Rev. 2002.
    Beckles Willson, N., Elliott, T. M., & Everard, M. L. (2002). Omega-3 fatty acids (from fish oils) for cystic fibrosis. The Cochrane Database of Systematic Reviews, (3), p. CD002201.
    Beckles Willson N, Elliott TM, Everard ML. Omega-3 Fatty Acids (from Fish Oils) for Cystic Fibrosis. Cochrane Database Syst Rev. 2002;(3)CD002201. PubMed PMID: 12137649.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Omega-3 fatty acids (from fish oils) for cystic fibrosis. AU - Beckles Willson,N, AU - Elliott,T M, AU - Everard,M L, PY - 2002/7/26/pubmed PY - 2002/9/25/medline PY - 2002/7/26/entrez SP - CD002201 EP - CD002201 JF - The Cochrane database of systematic reviews JO - Cochrane Database Syst Rev IS - 3 N2 - BACKGROUND: Epidemiological (population studies) and other studies suggest that a diet rich in omega-3 essential fatty acids (derived from fish oil) may have beneficial anti-inflammatory effects for chronic conditions such as cystic fibrosis. OBJECTIVES: To determine whether there is evidence that omega-3 polyunsaturated fatty acid supplementation reduces morbidity and mortality. To identify any adverse events associated with omega-3 polyunsaturated fatty acid supplementation. SEARCH STRATEGY: We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group specialised trials register, which comprises references identified from comprehensive electronic database searches, handsearching relevant journals and handsearching abstract books of conference proceedings. Authors and persons interested in the question were contacted. Date of the most recent search of the Group's specialised register: May 2002. SELECTION CRITERIA: Randomised controlled trials in patients with cystic fibrosis in which omega-3 fatty acid supplements were compared with a placebo oil. DATA COLLECTION AND ANALYSIS: Two reviewers independently selected the trials to be included in the review and assessed the methodological quality of the trials using two approaches: Cochrane assessment of allocation concealment and Jadad quality assessment score. Using data acquisition forms, two reviewers independently extracted data. Missing data has been requested. MAIN RESULTS: The initial literature search identified six trials. Two trials, involving 31 participants satisfied our inclusion criteria and were included in the review. Both compared omega-3 fatty acids to olive oil controls for a six week treatment period. One study (19 participants) showed an improvement in FEV1, FVC, Shwachman score and reduction in sputum volume in the fish oil group at the end of this short treatment period. REVIEWER'S CONCLUSIONS: The review of trials found that regular omega-3 supplements may provide some benefits for people with cystic fibrosis with relatively few adverse effects, although the evidence is insufficient to draw firm conclusions. There is insufficient evidence to recommend routine use of supplements of omega-3 fatty acids in people with cystic fibrosis. The most notable feature highlighted by this review was the lack of data for many of the outcomes likely to be meaningful to people with or making treatment decisions about CF. A large, long-term, multi-centre, randomised controlled study is needed in order to determine if there is a significant therapeutic effect and to assess the influence of disease severity, dosage and duration of treatment. Future researchers should note the need for additional pancreatic enzymes. SN - 1469-493X UR - https://www.unboundmedicine.com/medline/citation/12137649/Omega_3_fatty_acids__from_fish_oils__for_cystic_fibrosis_ L2 - https://doi.org/10.1002/14651858.CD002201 DB - PRIME DP - Unbound Medicine ER -