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Electrophoretic evaluation of nasal discharge in patients with allergic rhinitis and vasomotor rhinitis.
Am J Rhinol. 2002 May-Jun; 16(3):141-4.AJ

Abstract

BACKGROUND

Allergic rhinitis and vasomotor rhinitis are two common diseases that have similar symptoms and physical findings. This study was designed to assess the efficacy of electrophoretic analysis of nasal discharge for the differential diagnosis of allergic rhinitis and vasomotor rhinitis.

METHODS

Two different groups of patients with allergic rhinitis (n = 18) and with vasomotor rhinitis (n = 18) diagnosed by current methods and 10 healthy subjects as a control group were included in this study. Component analyses of proteins in nasal wash were made by sodium dodecyl sulfate-polyacrylamide gel electrophoresis.

RESULTS

The mean levels of total protein, 66-kDa proteins and 26-kDa proteins (277.2 +/- 9 microg/mL, 114.5 +/- 9 microg/mL, and 67.0 +/- 4 microg/mL, respectively), in nasal washing samples of patients with allergic rhinitis were found to be higher than in the samples, (222.0 +/- 6 microg/mL, 65.6 +/- 6 microg/mL, and 42.9 +/- 4 microg/mL respectively) obtained from patients with vasomotor rhinitis. The control group showed the lowest rate of these proteins (167.8 +/- 7 microg/mL 34.3 +/- 3 microg/mL, and 25.0 +/- 3 microg/mL, respectively). The differences between mean levels of these proteins in all groups were statistically significant (p < 0.05).

CONCLUSIONS

These findings indicate that electrophoretic analysis of nasal discharge can be used for the diagnosis of allergic rhinitis and vasomotor rhinitis. However, further studies are needed to standardize the technique of nasal wash and to determine the range of proteins in nasal secretions that will confirm the diagnosis.

Authors+Show Affiliations

Department of Otorhinolaryngology and Head and Neck Surgery, Gülhane Medical School, Etlik, Ankara, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

12141770

Citation

Tosun, Fuat, et al. "Electrophoretic Evaluation of Nasal Discharge in Patients With Allergic Rhinitis and Vasomotor Rhinitis." American Journal of Rhinology, vol. 16, no. 3, 2002, pp. 141-4.
Tosun F, Sezen I, Gerek M, et al. Electrophoretic evaluation of nasal discharge in patients with allergic rhinitis and vasomotor rhinitis. Am J Rhinol. 2002;16(3):141-4.
Tosun, F., Sezen, I., Gerek, M., Ozkaptan, Y., Yapar, M., Calişkaner, Z., & Akman, S. (2002). Electrophoretic evaluation of nasal discharge in patients with allergic rhinitis and vasomotor rhinitis. American Journal of Rhinology, 16(3), 141-4.
Tosun F, et al. Electrophoretic Evaluation of Nasal Discharge in Patients With Allergic Rhinitis and Vasomotor Rhinitis. Am J Rhinol. 2002 May-Jun;16(3):141-4. PubMed PMID: 12141770.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Electrophoretic evaluation of nasal discharge in patients with allergic rhinitis and vasomotor rhinitis. AU - Tosun,Fuat, AU - Sezen,Ilhan, AU - Gerek,Mustafa, AU - Ozkaptan,Yalçin, AU - Yapar,Mehmet, AU - Calişkaner,Zafer, AU - Akman,Serif, PY - 2002/7/27/pubmed PY - 2003/1/16/medline PY - 2002/7/27/entrez SP - 141 EP - 4 JF - American journal of rhinology JO - Am J Rhinol VL - 16 IS - 3 N2 - BACKGROUND: Allergic rhinitis and vasomotor rhinitis are two common diseases that have similar symptoms and physical findings. This study was designed to assess the efficacy of electrophoretic analysis of nasal discharge for the differential diagnosis of allergic rhinitis and vasomotor rhinitis. METHODS: Two different groups of patients with allergic rhinitis (n = 18) and with vasomotor rhinitis (n = 18) diagnosed by current methods and 10 healthy subjects as a control group were included in this study. Component analyses of proteins in nasal wash were made by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. RESULTS: The mean levels of total protein, 66-kDa proteins and 26-kDa proteins (277.2 +/- 9 microg/mL, 114.5 +/- 9 microg/mL, and 67.0 +/- 4 microg/mL, respectively), in nasal washing samples of patients with allergic rhinitis were found to be higher than in the samples, (222.0 +/- 6 microg/mL, 65.6 +/- 6 microg/mL, and 42.9 +/- 4 microg/mL respectively) obtained from patients with vasomotor rhinitis. The control group showed the lowest rate of these proteins (167.8 +/- 7 microg/mL 34.3 +/- 3 microg/mL, and 25.0 +/- 3 microg/mL, respectively). The differences between mean levels of these proteins in all groups were statistically significant (p < 0.05). CONCLUSIONS: These findings indicate that electrophoretic analysis of nasal discharge can be used for the diagnosis of allergic rhinitis and vasomotor rhinitis. However, further studies are needed to standardize the technique of nasal wash and to determine the range of proteins in nasal secretions that will confirm the diagnosis. SN - 1050-6586 UR - https://www.unboundmedicine.com/medline/citation/12141770/Electrophoretic_evaluation_of_nasal_discharge_in_patients_with_allergic_rhinitis_and_vasomotor_rhinitis_ L2 - https://www.diseaseinfosearch.org/result/7665 DB - PRIME DP - Unbound Medicine ER -