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A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity.
Science. 2002 Jul 26; 297(5581):623-6.Sci

Abstract

A genetic screen for Caenorhabditis elegans mutants with enhanced susceptibility to killing by Pseudomonas aeruginosa led to the identification of two genes required for pathogen resistance: sek-1, which encodes a mitogen-activated protein (MAP) kinase kinase, and nsy-1, which encodes a MAP kinase kinase kinase. RNA interference assays and biochemical analysis established that a p38 ortholog, pmk-1, functions as the downstream MAP kinase required for pathogen defense. These data suggest that this MAP kinase signaling cassette represents an ancient feature of innate immune responses in evolutionarily diverse species.

Authors+Show Affiliations

Kim DH
Department of Genetics, Harvard Medical School, Boston, MA 02114, USA.
Feinbaum R
No affiliation info available
Alloing G
No affiliation info available
Emerson FE
No affiliation info available
Garsin DA
No affiliation info available
Inoue H
No affiliation info available
Tanaka-Hino M
No affiliation info available
Hisamoto N
No affiliation info available
Matsumoto K
No affiliation info available
Tan MW
No affiliation info available
Ausubel FM
No affiliation info available

MeSH

AnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsGenes, HelminthImmunity, InnateMAP Kinase Signaling SystemMitogen-Activated Protein Kinase KinasesMitogen-Activated Protein KinasesMutationPhenotypePseudomonas aeruginosap38 Mitogen-Activated Protein Kinases

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12142542

Citation

Kim, Dennis H., et al. "A Conserved P38 MAP Kinase Pathway in Caenorhabditis Elegans Innate Immunity." Science (New York, N.Y.), vol. 297, no. 5581, 2002, pp. 623-6.
Kim DH, Feinbaum R, Alloing G, et al. A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity. Science. 2002;297(5581):623-6.
Kim, D. H., Feinbaum, R., Alloing, G., Emerson, F. E., Garsin, D. A., Inoue, H., Tanaka-Hino, M., Hisamoto, N., Matsumoto, K., Tan, M. W., & Ausubel, F. M. (2002). A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity. Science (New York, N.Y.), 297(5581), 623-6.
Kim DH, et al. A Conserved P38 MAP Kinase Pathway in Caenorhabditis Elegans Innate Immunity. Science. 2002 Jul 26;297(5581):623-6. PubMed PMID: 12142542.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity. AU - Kim,Dennis H, AU - Feinbaum,Rhonda, AU - Alloing,Geneviève, AU - Emerson,Fred E, AU - Garsin,Danielle A, AU - Inoue,Hideki, AU - Tanaka-Hino,Miho, AU - Hisamoto,Naoki, AU - Matsumoto,Kunihiro, AU - Tan,Man-Wah, AU - Ausubel,Frederick M, PY - 2002/7/27/pubmed PY - 2002/8/21/medline PY - 2002/7/27/entrez SP - 623 EP - 6 JF - Science (New York, N.Y.) JO - Science VL - 297 IS - 5581 N2 - A genetic screen for Caenorhabditis elegans mutants with enhanced susceptibility to killing by Pseudomonas aeruginosa led to the identification of two genes required for pathogen resistance: sek-1, which encodes a mitogen-activated protein (MAP) kinase kinase, and nsy-1, which encodes a MAP kinase kinase kinase. RNA interference assays and biochemical analysis established that a p38 ortholog, pmk-1, functions as the downstream MAP kinase required for pathogen defense. These data suggest that this MAP kinase signaling cassette represents an ancient feature of innate immune responses in evolutionarily diverse species. SN - 1095-9203 UR - https://www.unboundmedicine.com/medline/citation/12142542/A_conserved_p38_MAP_kinase_pathway_in_Caenorhabditis_elegans_innate_immunity_ DB - PRIME DP - Unbound Medicine ER -