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Nutrition and the immune system from birth to old age.

Abstract

For millennia, food has been at the center of social events, in times of joy and in times of sorrow. Protein-energy malnutrition is associated with a significant impairment of cell-mediated immunity, phagocyte function, complement system, secretory immunoglobulin A antibody concentrations, and cytokine production. Deficiency of single nutrients also results in altered immune response: this is observed even when the deficiency state is relatively mild. Of the micronutrients, zinc, selenium, iron, copper, vitamins A, C, E and B(6), and folic acid have important influences on immune responses. Overnutrition and obesity also reduce immunity. Low-birth-weight infants have a prolonged impairment of cell-mediated immunity that can be partly restored by providing extra amounts of dietary zinc. In the elderly, impaired immunity can be enhanced by modest amounts of a combination of micronutrients. These findings have considerable practical and public health significance.

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  • Authors+Show Affiliations

    Memorial University of Newfoundland, WHO Centre for Nutritional Immunology, Janeway Child Health Centre, St John's, Canada. rkchandra_2000@yahoo.com

    Source

    European journal of clinical nutrition 56 Suppl 3: 2002 Aug pg S73-6

    MeSH

    Adolescent
    Adult
    Aged
    Aging
    Child
    Child, Preschool
    Deficiency Diseases
    Humans
    Immune System
    Infant
    Infant, Low Birth Weight
    Infant, Newborn
    Micronutrients
    Middle Aged
    Nutritional Physiological Phenomena
    Protein-Energy Malnutrition
    Vitamins

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    12142969

    Citation

    Chandra, R K.. "Nutrition and the Immune System From Birth to Old Age." European Journal of Clinical Nutrition, vol. 56 Suppl 3, 2002, pp. S73-6.
    Chandra RK. Nutrition and the immune system from birth to old age. Eur J Clin Nutr. 2002;56 Suppl 3:S73-6.
    Chandra, R. K. (2002). Nutrition and the immune system from birth to old age. European Journal of Clinical Nutrition, 56 Suppl 3, pp. S73-6.
    Chandra RK. Nutrition and the Immune System From Birth to Old Age. Eur J Clin Nutr. 2002;56 Suppl 3:S73-6. PubMed PMID: 12142969.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Nutrition and the immune system from birth to old age. A1 - Chandra,R K, PY - 2002/7/27/pubmed PY - 2002/11/30/medline PY - 2002/7/27/entrez SP - S73 EP - 6 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 56 Suppl 3 N2 - For millennia, food has been at the center of social events, in times of joy and in times of sorrow. Protein-energy malnutrition is associated with a significant impairment of cell-mediated immunity, phagocyte function, complement system, secretory immunoglobulin A antibody concentrations, and cytokine production. Deficiency of single nutrients also results in altered immune response: this is observed even when the deficiency state is relatively mild. Of the micronutrients, zinc, selenium, iron, copper, vitamins A, C, E and B(6), and folic acid have important influences on immune responses. Overnutrition and obesity also reduce immunity. Low-birth-weight infants have a prolonged impairment of cell-mediated immunity that can be partly restored by providing extra amounts of dietary zinc. In the elderly, impaired immunity can be enhanced by modest amounts of a combination of micronutrients. These findings have considerable practical and public health significance. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/12142969/Nutrition_and_the_immune_system_from_birth_to_old_age_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1601492 DB - PRIME DP - Unbound Medicine ER -