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Nutrition and the immune system from birth to old age.
Eur J Clin Nutr 2002; 56 Suppl 3:S73-6EJ

Abstract

For millennia, food has been at the center of social events, in times of joy and in times of sorrow. Protein-energy malnutrition is associated with a significant impairment of cell-mediated immunity, phagocyte function, complement system, secretory immunoglobulin A antibody concentrations, and cytokine production. Deficiency of single nutrients also results in altered immune response: this is observed even when the deficiency state is relatively mild. Of the micronutrients, zinc, selenium, iron, copper, vitamins A, C, E and B(6), and folic acid have important influences on immune responses. Overnutrition and obesity also reduce immunity. Low-birth-weight infants have a prolonged impairment of cell-mediated immunity that can be partly restored by providing extra amounts of dietary zinc. In the elderly, impaired immunity can be enhanced by modest amounts of a combination of micronutrients. These findings have considerable practical and public health significance.

Authors+Show Affiliations

Memorial University of Newfoundland, WHO Centre for Nutritional Immunology, Janeway Child Health Centre, St John's, Canada. rkchandra_2000@yahoo.com

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

12142969

Citation

Chandra, R K.. "Nutrition and the Immune System From Birth to Old Age." European Journal of Clinical Nutrition, vol. 56 Suppl 3, 2002, pp. S73-6.
Chandra RK. Nutrition and the immune system from birth to old age. Eur J Clin Nutr. 2002;56 Suppl 3:S73-6.
Chandra, R. K. (2002). Nutrition and the immune system from birth to old age. European Journal of Clinical Nutrition, 56 Suppl 3, pp. S73-6.
Chandra RK. Nutrition and the Immune System From Birth to Old Age. Eur J Clin Nutr. 2002;56 Suppl 3:S73-6. PubMed PMID: 12142969.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nutrition and the immune system from birth to old age. A1 - Chandra,R K, PY - 2002/7/27/pubmed PY - 2002/11/30/medline PY - 2002/7/27/entrez SP - S73 EP - 6 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 56 Suppl 3 N2 - For millennia, food has been at the center of social events, in times of joy and in times of sorrow. Protein-energy malnutrition is associated with a significant impairment of cell-mediated immunity, phagocyte function, complement system, secretory immunoglobulin A antibody concentrations, and cytokine production. Deficiency of single nutrients also results in altered immune response: this is observed even when the deficiency state is relatively mild. Of the micronutrients, zinc, selenium, iron, copper, vitamins A, C, E and B(6), and folic acid have important influences on immune responses. Overnutrition and obesity also reduce immunity. Low-birth-weight infants have a prolonged impairment of cell-mediated immunity that can be partly restored by providing extra amounts of dietary zinc. In the elderly, impaired immunity can be enhanced by modest amounts of a combination of micronutrients. These findings have considerable practical and public health significance. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/12142969/Nutrition_and_the_immune_system_from_birth_to_old_age_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1601492 DB - PRIME DP - Unbound Medicine ER -