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Risk factors for esophageal variceal bleeding in patients with hepatocellular carcinoma.
Hepatogastroenterology. 2002 Jul-Aug; 49(46):1039-44.H

Abstract

BACKGROUND/AIMS

To evaluate the risk factors for esophageal variceal bleeding in patients with hepatocellular carcinoma.

METHODOLOGY

103 patients with esophageal varices and hepatocellular carcinoma without previous history of varices bleeding or treatment of varices were followed up and the risk factors for variceal bleeding were evaluated by Cox proportional hazards regression.

RESULTS

During an average of 650 days' follow-up, 17 patients (17%) suffered from variceal bleeding, showing an annual incidence rate of 9.3%. Another 8 patients (8%) underwent endoscopic variceal ligation for the aggravation of esophageal varices. Multivariate analysis showed that the red color sign of varices and the size of tumor (> or = 33 mm) were independently associated with an increased risk of variceal bleeding (Risk Ratio = 20.33, P < 0.0001 and Risk Ratio = 2.64, P = 0.0231, respectively).

CONCLUSIONS

The large size of tumor, as well as the red color sign of varices, was a significant risk factor for variceal bleeding in patients with hepatocellular carcinoma.

Authors+Show Affiliations

Division of Gastroenterology, Department of Internal Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. makanuma@qd6.so-net.ne.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12143197

Citation

Akanuma, Masao, et al. "Risk Factors for Esophageal Variceal Bleeding in Patients With Hepatocellular Carcinoma." Hepato-gastroenterology, vol. 49, no. 46, 2002, pp. 1039-44.
Akanuma M, Yoshida H, Okamoto M, et al. Risk factors for esophageal variceal bleeding in patients with hepatocellular carcinoma. Hepatogastroenterology. 2002;49(46):1039-44.
Akanuma, M., Yoshida, H., Okamoto, M., Ogura, K., Maeda, S., Hata, Y., Sato, S., Shiina, S., Kawabe, T., Shiratori, Y., & Omata, M. (2002). Risk factors for esophageal variceal bleeding in patients with hepatocellular carcinoma. Hepato-gastroenterology, 49(46), 1039-44.
Akanuma M, et al. Risk Factors for Esophageal Variceal Bleeding in Patients With Hepatocellular Carcinoma. Hepatogastroenterology. 2002 Jul-Aug;49(46):1039-44. PubMed PMID: 12143197.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk factors for esophageal variceal bleeding in patients with hepatocellular carcinoma. AU - Akanuma,Masao, AU - Yoshida,Haruhiko, AU - Okamoto,Makoto, AU - Ogura,Keiji, AU - Maeda,Shin, AU - Hata,Yasuo, AU - Sato,Shinpei, AU - Shiina,Shuichiro, AU - Kawabe,Takao, AU - Shiratori,Yasushi, AU - Omata,Masao, PY - 2002/7/30/pubmed PY - 2003/2/14/medline PY - 2002/7/30/entrez SP - 1039 EP - 44 JF - Hepato-gastroenterology JO - Hepatogastroenterology VL - 49 IS - 46 N2 - BACKGROUND/AIMS: To evaluate the risk factors for esophageal variceal bleeding in patients with hepatocellular carcinoma. METHODOLOGY: 103 patients with esophageal varices and hepatocellular carcinoma without previous history of varices bleeding or treatment of varices were followed up and the risk factors for variceal bleeding were evaluated by Cox proportional hazards regression. RESULTS: During an average of 650 days' follow-up, 17 patients (17%) suffered from variceal bleeding, showing an annual incidence rate of 9.3%. Another 8 patients (8%) underwent endoscopic variceal ligation for the aggravation of esophageal varices. Multivariate analysis showed that the red color sign of varices and the size of tumor (> or = 33 mm) were independently associated with an increased risk of variceal bleeding (Risk Ratio = 20.33, P < 0.0001 and Risk Ratio = 2.64, P = 0.0231, respectively). CONCLUSIONS: The large size of tumor, as well as the red color sign of varices, was a significant risk factor for variceal bleeding in patients with hepatocellular carcinoma. SN - 0172-6390 UR - https://www.unboundmedicine.com/medline/citation/12143197/Risk_factors_for_esophageal_variceal_bleeding_in_patients_with_hepatocellular_carcinoma_ L2 - https://medlineplus.gov/livercancer.html DB - PRIME DP - Unbound Medicine ER -