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Comparison of serum CA72-4, CEA, TPA, CA19-9 and CA125 levels in gastric cancer patients and correlation with recurrence.
Hepatogastroenterology. 2002 Jul-Aug; 49(46):1157-60.H

Abstract

BACKGROUND/AIMS

Serum tumor markers were investigated as prognostic factors for recurrence in patients with gastric cancers.

METHODOLOGY

Preoperative serum levels of CEA, CA72-4, CA19-9, TPA and CA125 were sampled in 196 patients with gastric cancers undergoing curative surgery. The results were compared with the clinical recurrence and various clinicopathological factors.

RESULTS

CA72-4, CEA, CA19-9, TPA and CA125 had sensitivities of 16.4%, 31.4%, 16.1%, 31.6%, and 6%, respectively. Sensitivity of two combinations was as high as 56.5%. Seventy-seven patients (39.9%) had clinical recurrence in the follow-up periods. For those with preoperatively elevated serum tumor markers, 38% (12/32) had CA72-4, 42% (13/31) had CA19-9, 48% (29/60) and had CEA, 54% (6/11) had CA125, and 62% (37/61) had TPA, and remained disease-free. Univariate analysis showed that TNM staging, Tumor size, Borrmann classification of tumor growth, and preoperative serum CA72-4 level were correlated with recurrence of disease. Multivariate analysis showed that independent prognostic factor of recurrence was TNM staging (P = 0.0007).

CONCLUSIONS

Preoperative serum CA72-4 level is correlated with staging of disease, but is not an independent predictor for clinical recurrence of disease in patients with gastric cancers that undergo surgery.

Authors+Show Affiliations

Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

12143226

Citation

Lai, I-Rue, et al. "Comparison of Serum CA72-4, CEA, TPA, CA19-9 and CA125 Levels in Gastric Cancer Patients and Correlation With Recurrence." Hepato-gastroenterology, vol. 49, no. 46, 2002, pp. 1157-60.
Lai IR, Lee WJ, Huang MT, et al. Comparison of serum CA72-4, CEA, TPA, CA19-9 and CA125 levels in gastric cancer patients and correlation with recurrence. Hepatogastroenterology. 2002;49(46):1157-60.
Lai, I. R., Lee, W. J., Huang, M. T., & Lin, H. H. (2002). Comparison of serum CA72-4, CEA, TPA, CA19-9 and CA125 levels in gastric cancer patients and correlation with recurrence. Hepato-gastroenterology, 49(46), 1157-60.
Lai IR, et al. Comparison of Serum CA72-4, CEA, TPA, CA19-9 and CA125 Levels in Gastric Cancer Patients and Correlation With Recurrence. Hepatogastroenterology. 2002 Jul-Aug;49(46):1157-60. PubMed PMID: 12143226.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of serum CA72-4, CEA, TPA, CA19-9 and CA125 levels in gastric cancer patients and correlation with recurrence. AU - Lai,I-Rue, AU - Lee,Wei-Jei, AU - Huang,Ming-Te, AU - Lin,Hshu-Hshing, PY - 2002/7/30/pubmed PY - 2003/2/14/medline PY - 2002/7/30/entrez SP - 1157 EP - 60 JF - Hepato-gastroenterology JO - Hepatogastroenterology VL - 49 IS - 46 N2 - BACKGROUND/AIMS: Serum tumor markers were investigated as prognostic factors for recurrence in patients with gastric cancers. METHODOLOGY: Preoperative serum levels of CEA, CA72-4, CA19-9, TPA and CA125 were sampled in 196 patients with gastric cancers undergoing curative surgery. The results were compared with the clinical recurrence and various clinicopathological factors. RESULTS: CA72-4, CEA, CA19-9, TPA and CA125 had sensitivities of 16.4%, 31.4%, 16.1%, 31.6%, and 6%, respectively. Sensitivity of two combinations was as high as 56.5%. Seventy-seven patients (39.9%) had clinical recurrence in the follow-up periods. For those with preoperatively elevated serum tumor markers, 38% (12/32) had CA72-4, 42% (13/31) had CA19-9, 48% (29/60) and had CEA, 54% (6/11) had CA125, and 62% (37/61) had TPA, and remained disease-free. Univariate analysis showed that TNM staging, Tumor size, Borrmann classification of tumor growth, and preoperative serum CA72-4 level were correlated with recurrence of disease. Multivariate analysis showed that independent prognostic factor of recurrence was TNM staging (P = 0.0007). CONCLUSIONS: Preoperative serum CA72-4 level is correlated with staging of disease, but is not an independent predictor for clinical recurrence of disease in patients with gastric cancers that undergo surgery. SN - 0172-6390 UR - https://www.unboundmedicine.com/medline/citation/12143226/Comparison_of_serum_CA72_4_CEA_TPA_CA19_9_and_CA125_levels_in_gastric_cancer_patients_and_correlation_with_recurrence_ L2 - https://medlineplus.gov/stomachcancer.html DB - PRIME DP - Unbound Medicine ER -