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Maintaining higher TSATs and other iron indices is beneficial in management of anemic hemodialysis patients.
Nephrol Nurs J. 2001 Aug; 28(4):429-34.NN

Abstract

The National Kidney Foundation Kidney Disease Outcomes Quality Initiative and other groups support maintaining transferrin saturation (TSAT) levels above 20% and serum ferritin levels above 100 ng/ml to ensure adequate erythropoiesis in hemodialysis patients receiving erythropoietin. However, researchers have found that even patients with TSATs above 20% may still have functional iron deficiency. This article presents information that supports the fact that maintenance of TSATs between 30% and 50%, through the use of continuous intravenous iron therapy, results in improvement of anemia, reduction in erythropoietin dose requirements, and an increase in the reticulocyte hemoglobin content. The implications of these findings for clinical practice are also discussed.

Authors+Show Affiliations

Besarab A
West Virginia University School of Medicine, Dialysis Unit, Ruby Memorial Hospital, Morgantown, WV, USA.
Dalton CL
No affiliation info available

MeSH

AlgorithmsAnemia, Iron-DeficiencyClinical ProtocolsDecision TreesDrug MonitoringErythropoietinEvidence-Based MedicineFerritinsHumansIron-Dextran ComplexKidney Failure, ChronicRenal DialysisTotal Quality ManagementTransferrinTreatment Outcome

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

12143465

Citation

Besarab, A, and C L. Dalton. "Maintaining Higher TSATs and Other Iron Indices Is Beneficial in Management of Anemic Hemodialysis Patients." Nephrology Nursing Journal : Journal of the American Nephrology Nurses' Association, vol. 28, no. 4, 2001, pp. 429-34.
Besarab A, Dalton CL. Maintaining higher TSATs and other iron indices is beneficial in management of anemic hemodialysis patients. Nephrol Nurs J. 2001;28(4):429-34.
Besarab, A., & Dalton, C. L. (2001). Maintaining higher TSATs and other iron indices is beneficial in management of anemic hemodialysis patients. Nephrology Nursing Journal : Journal of the American Nephrology Nurses' Association, 28(4), 429-34.
Besarab A, Dalton CL. Maintaining Higher TSATs and Other Iron Indices Is Beneficial in Management of Anemic Hemodialysis Patients. Nephrol Nurs J. 2001;28(4):429-34. PubMed PMID: 12143465.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maintaining higher TSATs and other iron indices is beneficial in management of anemic hemodialysis patients. AU - Besarab,A, AU - Dalton,C L, PY - 2002/7/30/pubmed PY - 2002/8/14/medline PY - 2002/7/30/entrez SP - 429 EP - 34 JF - Nephrology nursing journal : journal of the American Nephrology Nurses' Association JO - Nephrol Nurs J VL - 28 IS - 4 N2 - The National Kidney Foundation Kidney Disease Outcomes Quality Initiative and other groups support maintaining transferrin saturation (TSAT) levels above 20% and serum ferritin levels above 100 ng/ml to ensure adequate erythropoiesis in hemodialysis patients receiving erythropoietin. However, researchers have found that even patients with TSATs above 20% may still have functional iron deficiency. This article presents information that supports the fact that maintenance of TSATs between 30% and 50%, through the use of continuous intravenous iron therapy, results in improvement of anemia, reduction in erythropoietin dose requirements, and an increase in the reticulocyte hemoglobin content. The implications of these findings for clinical practice are also discussed. SN - 1526-744X UR - https://www.unboundmedicine.com/medline/citation/12143465/Maintaining_higher_TSATs_and_other_iron_indices_is_beneficial_in_management_of_anemic_hemodialysis_patients_ L2 - https://medlineplus.gov/kidneyfailure.html DB - PRIME DP - Unbound Medicine ER -