Tags

Type your tag names separated by a space and hit enter

Desaturase activities are depleted before and after weaning in liver microsomes of spontaneously hypertensive rats.
Prostaglandins Leukot Essent Fatty Acids. 2002 May-Jun; 66(5-6):541-7.PL

Abstract

In the present study, we have investigated the microsomal linoleic acid desaturation steps into arachidonic acid in 10- and 30-day-old spontaneously hypertensive rats (SHR), as compared to their normotensive control rats, Wistar Kyoto (WKY). Suckled by adoptive Wistar normotensive female, the SHR and WKY were fed the same diet. Our results show lower Delta 6 and Delta 5 desaturase activities (the limiting steps in the bioconversion of linoleic acid into arachidonic acid) in the young SHR, as compared to the WKY normotensive rats. The fatty acid composition of liver microsomal total lipids evidences a higher proportion of linoleic acid in SHR than in WKY, in agreement with the partially depleted desaturase activities. Such a loss of desaturase activities may be under the control of hormones involved in the regulation of SHR blood pressure.

Authors+Show Affiliations

Université de Corse, BP 52, Corté, France.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

12144877

Citation

Savelli, J L., et al. "Desaturase Activities Are Depleted Before and After Weaning in Liver Microsomes of Spontaneously Hypertensive Rats." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 66, no. 5-6, 2002, pp. 541-7.
Savelli JL, Narce M, Fustier V, et al. Desaturase activities are depleted before and after weaning in liver microsomes of spontaneously hypertensive rats. Prostaglandins Leukot Essent Fatty Acids. 2002;66(5-6):541-7.
Savelli, J. L., Narce, M., Fustier, V., & Poisson, J. P. (2002). Desaturase activities are depleted before and after weaning in liver microsomes of spontaneously hypertensive rats. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 66(5-6), 541-7.
Savelli JL, et al. Desaturase Activities Are Depleted Before and After Weaning in Liver Microsomes of Spontaneously Hypertensive Rats. Prostaglandins Leukot Essent Fatty Acids. 2002 May-Jun;66(5-6):541-7. PubMed PMID: 12144877.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Desaturase activities are depleted before and after weaning in liver microsomes of spontaneously hypertensive rats. AU - Savelli,J L, AU - Narce,M, AU - Fustier,V, AU - Poisson,J-P, PY - 2002/7/30/pubmed PY - 2003/3/8/medline PY - 2002/7/30/entrez SP - 541 EP - 7 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot Essent Fatty Acids VL - 66 IS - 5-6 N2 - In the present study, we have investigated the microsomal linoleic acid desaturation steps into arachidonic acid in 10- and 30-day-old spontaneously hypertensive rats (SHR), as compared to their normotensive control rats, Wistar Kyoto (WKY). Suckled by adoptive Wistar normotensive female, the SHR and WKY were fed the same diet. Our results show lower Delta 6 and Delta 5 desaturase activities (the limiting steps in the bioconversion of linoleic acid into arachidonic acid) in the young SHR, as compared to the WKY normotensive rats. The fatty acid composition of liver microsomal total lipids evidences a higher proportion of linoleic acid in SHR than in WKY, in agreement with the partially depleted desaturase activities. Such a loss of desaturase activities may be under the control of hormones involved in the regulation of SHR blood pressure. SN - 0952-3278 UR - https://www.unboundmedicine.com/medline/citation/12144877/Desaturase_activities_are_depleted_before_and_after_weaning_in_liver_microsomes_of_spontaneously_hypertensive_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952327802903972 DB - PRIME DP - Unbound Medicine ER -