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Changes in LDL particle composition after the consumption of meals containing different amounts and types of fat.
Am J Clin Nutr. 2002 Aug; 76(2):345-50.AJ

Abstract

BACKGROUND

Remodeling of lipoprotein particles in the postprandial period is considered to be an important source of atherogenic particles, but acute changes occurring after meals have been little studied.

OBJECTIVE

We sought to characterize changes in LDL particle composition occurring after a single meal, with particular reference to potential lipid exchange with particles carrying dietary fatty acids.

DESIGN

In a balanced design, 8 healthy subjects ingested isoenergetic meals of different fat content: low-fat, rich in saturated fatty acids (SFAs), and rich in polyunsaturated fatty acids (PUFAs). We investigated changes in LDL composition 4 and 6 h after meal ingestion.

RESULTS

The LDL triacylglycerol-to-protein ratio closely mirrored the plasma triacylglycerol concentrations after each of the meals, and there was a strong association between these variables in both the fasting and postprandial states (P < 0.001). A postprandial increase in LDL triacylglycerol was associated with a decrease in LDL cholesterol. There were no effects of the ingestion of a single meal on the LDL density profiles for protein or for any of the lipid components. The fatty acid composition of total LDL lipids changed in the postprandial period, with an enrichment in PUFA after the PUFA-rich meal and in SFA after the SFA-rich meal.

CONCLUSIONS

The changes observed in LDL composition after single meals are in accord with the proposition that there is neutral lipid exchange in the postprandial period, with triacylglycerol enrichment of LDL particles at the expense of cholesteryl esters. The change in the fatty acid composition of LDL particles implies significant lipid exchange with particles containing dietary fat.

Authors+Show Affiliations

Oxford Lipid Metabolism Group, the Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Infirmary, Oxford, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12145005

Citation

Callow, Joanne, et al. "Changes in LDL Particle Composition After the Consumption of Meals Containing Different Amounts and Types of Fat." The American Journal of Clinical Nutrition, vol. 76, no. 2, 2002, pp. 345-50.
Callow J, Summers LK, Bradshaw H, et al. Changes in LDL particle composition after the consumption of meals containing different amounts and types of fat. Am J Clin Nutr. 2002;76(2):345-50.
Callow, J., Summers, L. K., Bradshaw, H., & Frayn, K. N. (2002). Changes in LDL particle composition after the consumption of meals containing different amounts and types of fat. The American Journal of Clinical Nutrition, 76(2), 345-50.
Callow J, et al. Changes in LDL Particle Composition After the Consumption of Meals Containing Different Amounts and Types of Fat. Am J Clin Nutr. 2002;76(2):345-50. PubMed PMID: 12145005.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in LDL particle composition after the consumption of meals containing different amounts and types of fat. AU - Callow,Joanne, AU - Summers,Lucinda K M, AU - Bradshaw,Hilary, AU - Frayn,Keith N, PY - 2002/7/30/pubmed PY - 2002/8/14/medline PY - 2002/7/30/entrez SP - 345 EP - 50 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 76 IS - 2 N2 - BACKGROUND: Remodeling of lipoprotein particles in the postprandial period is considered to be an important source of atherogenic particles, but acute changes occurring after meals have been little studied. OBJECTIVE: We sought to characterize changes in LDL particle composition occurring after a single meal, with particular reference to potential lipid exchange with particles carrying dietary fatty acids. DESIGN: In a balanced design, 8 healthy subjects ingested isoenergetic meals of different fat content: low-fat, rich in saturated fatty acids (SFAs), and rich in polyunsaturated fatty acids (PUFAs). We investigated changes in LDL composition 4 and 6 h after meal ingestion. RESULTS: The LDL triacylglycerol-to-protein ratio closely mirrored the plasma triacylglycerol concentrations after each of the meals, and there was a strong association between these variables in both the fasting and postprandial states (P < 0.001). A postprandial increase in LDL triacylglycerol was associated with a decrease in LDL cholesterol. There were no effects of the ingestion of a single meal on the LDL density profiles for protein or for any of the lipid components. The fatty acid composition of total LDL lipids changed in the postprandial period, with an enrichment in PUFA after the PUFA-rich meal and in SFA after the SFA-rich meal. CONCLUSIONS: The changes observed in LDL composition after single meals are in accord with the proposition that there is neutral lipid exchange in the postprandial period, with triacylglycerol enrichment of LDL particles at the expense of cholesteryl esters. The change in the fatty acid composition of LDL particles implies significant lipid exchange with particles containing dietary fat. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/12145005/Changes_in_LDL_particle_composition_after_the_consumption_of_meals_containing_different_amounts_and_types_of_fat_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/76.2.345 DB - PRIME DP - Unbound Medicine ER -