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Cross-talk between iron metabolism and diabetes.
Diabetes 2002; 51(8):2348-54D

Abstract

Emerging scientific evidence has disclosed unsuspected influences between iron metabolism and type 2 diabetes. The relationship is bi-directional--iron affects glucose metabolism, and glucose metabolism impinges on several iron metabolic pathways. Oxidative stress and inflammatory cytokines influence these relationships, amplifying and potentiating the initiated events. The clinical impact of these interactions depends on both the genetic predisposition and the time frame in which this network of closely related signals acts. In recent years, increased iron stores have been found to predict the development of type 2 diabetes while iron depletion was protective. Iron-induced damage might also modulate the development of chronic diabetes complications. Iron depletion has been demonstrated to be beneficial in coronary artery responses, endothelial dysfunction, insulin secretion, insulin action, and metabolic control in type 2 diabetes. Here, we show that iron modulates insulin action in healthy individuals and in patients with type 2 diabetes. The extent of this influence should be tested in large-scale clinical trials, searching for the usefulness and cost-effectiveness of therapeutic measures that decrease iron toxicity. The study of individual susceptibility and of the mechanisms that influence tissue iron deposition and damage are proposed to be valuable in anticipating and treating diabetes complications.

Authors+Show Affiliations

Unit of Diabetes, Endocrinology and Nutrition, University Hospital of Girona Dr Josep Trueta, Girona, Spain. endocrino@htrueta.scs.esNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

12145144

Citation

Fernández-Real, José Manuel, et al. "Cross-talk Between Iron Metabolism and Diabetes." Diabetes, vol. 51, no. 8, 2002, pp. 2348-54.
Fernández-Real JM, López-Bermejo A, Ricart W. Cross-talk between iron metabolism and diabetes. Diabetes. 2002;51(8):2348-54.
Fernández-Real, J. M., López-Bermejo, A., & Ricart, W. (2002). Cross-talk between iron metabolism and diabetes. Diabetes, 51(8), pp. 2348-54.
Fernández-Real JM, López-Bermejo A, Ricart W. Cross-talk Between Iron Metabolism and Diabetes. Diabetes. 2002;51(8):2348-54. PubMed PMID: 12145144.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cross-talk between iron metabolism and diabetes. AU - Fernández-Real,José Manuel, AU - López-Bermejo,Abel, AU - Ricart,Wifredo, PY - 2002/7/30/pubmed PY - 2002/8/22/medline PY - 2002/7/30/entrez SP - 2348 EP - 54 JF - Diabetes JO - Diabetes VL - 51 IS - 8 N2 - Emerging scientific evidence has disclosed unsuspected influences between iron metabolism and type 2 diabetes. The relationship is bi-directional--iron affects glucose metabolism, and glucose metabolism impinges on several iron metabolic pathways. Oxidative stress and inflammatory cytokines influence these relationships, amplifying and potentiating the initiated events. The clinical impact of these interactions depends on both the genetic predisposition and the time frame in which this network of closely related signals acts. In recent years, increased iron stores have been found to predict the development of type 2 diabetes while iron depletion was protective. Iron-induced damage might also modulate the development of chronic diabetes complications. Iron depletion has been demonstrated to be beneficial in coronary artery responses, endothelial dysfunction, insulin secretion, insulin action, and metabolic control in type 2 diabetes. Here, we show that iron modulates insulin action in healthy individuals and in patients with type 2 diabetes. The extent of this influence should be tested in large-scale clinical trials, searching for the usefulness and cost-effectiveness of therapeutic measures that decrease iron toxicity. The study of individual susceptibility and of the mechanisms that influence tissue iron deposition and damage are proposed to be valuable in anticipating and treating diabetes complications. SN - 0012-1797 UR - https://www.unboundmedicine.com/medline/citation/12145144/full_citation L2 - http://diabetes.diabetesjournals.org/cgi/pmidlookup?view=long&pmid=12145144 DB - PRIME DP - Unbound Medicine ER -