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Comparison of energy prediction equations with measured resting energy expenditure in children with sickle cell anemia.

Abstract

OBJECTIVE

To determine the accuracy of energy prediction equations when compared with measured resting energy expenditure (REE) in children with sickle cell anemia. To develop a modified equation that more accurately estimates the energy needs of children with sickle cell anemia and to cross-validate these on a different set of patients (test patients).

DESIGN

REE was measured in children using indirect calorimetry and compared with predicted values using the Harris-Benedict and the Food and Agriculture Organization/World Health Organization/United Nations University equations (WHO).

SUBJECTS/SETTING

Eighteen patients participated in the original sample that compared predicted with measured energy expenditure. The modified equations were developed using the original 18 patients. A test population of 20 different patients was used to validate the modified equations.

STATISTICAL ANALYSIS

Wilcoxon signed-rank test was performed to compare measured with predicted REE. The correlation analysis method and multiple linear regression method were used to develop 2 modified versions for the Harris-Benedict and WHO prediction equations.

RESULTS

When compared with the mean predicted REE using the Harris-Benedict and WHO equations, the mean measured REE was 14% and 12% greater than both (P=.005 and P=.014, respectively). Two modified equations were developed from the Harris-Benedict and WHO equations. Based on the data from the test patients, the mean measured REE was 15% greater than the mean predicted REE based on the Harris-Benedict and WHO equations (P=.0001 for both). When the modified Harris-Benedict and WHO equations were used, there was almost no difference in the mean measured REE and the mean predicted REE (mean difference using Harris-Benedict = 14, P = .9273; mean difference using WHO = -13, P = .6215).

CONCLUSION

Both energy prediction equations underestimated REE in children with sickle cell anemia. The 2 modified versions of the energy prediction equations that we propose predicted the energy needs of these children much more accurately; however, the modified equations need to be validated through application to other children with sickle cell anemia.

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  • Authors+Show Affiliations

    ,

    Clinical Nutrition Services, St Jude Children's Research Hospital, Memphis, TN 38105-2794, USA. ruth.williams@stjude.org

    , , , ,

    Source

    MeSH

    Analysis of Variance
    Anemia, Sickle Cell
    Anthropometry
    Basal Metabolism
    Calorimetry, Indirect
    Child
    Child, Preschool
    Female
    Humans
    Male
    Mathematics
    Nutrition Assessment
    Predictive Value of Tests
    Reproducibility of Results
    Statistics, Nonparametric
    World Health Organization

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    12146559

    Citation

    TY - JOUR T1 - Comparison of energy prediction equations with measured resting energy expenditure in children with sickle cell anemia. AU - Williams,Ruth, AU - Olivi,Stacie, AU - Mackert,Paul, AU - Fletcher,Lucille, AU - Tian,Guo-Liang, AU - Wang,Winfred, PY - 2002/7/31/pubmed PY - 2002/8/14/medline PY - 2002/7/31/entrez SP - 956 EP - 61 JF - Journal of the American Dietetic Association JO - J Am Diet Assoc VL - 102 IS - 7 N2 - OBJECTIVE: To determine the accuracy of energy prediction equations when compared with measured resting energy expenditure (REE) in children with sickle cell anemia. To develop a modified equation that more accurately estimates the energy needs of children with sickle cell anemia and to cross-validate these on a different set of patients (test patients). DESIGN: REE was measured in children using indirect calorimetry and compared with predicted values using the Harris-Benedict and the Food and Agriculture Organization/World Health Organization/United Nations University equations (WHO). SUBJECTS/SETTING: Eighteen patients participated in the original sample that compared predicted with measured energy expenditure. The modified equations were developed using the original 18 patients. A test population of 20 different patients was used to validate the modified equations. STATISTICAL ANALYSIS: Wilcoxon signed-rank test was performed to compare measured with predicted REE. The correlation analysis method and multiple linear regression method were used to develop 2 modified versions for the Harris-Benedict and WHO prediction equations. RESULTS: When compared with the mean predicted REE using the Harris-Benedict and WHO equations, the mean measured REE was 14% and 12% greater than both (P=.005 and P=.014, respectively). Two modified equations were developed from the Harris-Benedict and WHO equations. Based on the data from the test patients, the mean measured REE was 15% greater than the mean predicted REE based on the Harris-Benedict and WHO equations (P=.0001 for both). When the modified Harris-Benedict and WHO equations were used, there was almost no difference in the mean measured REE and the mean predicted REE (mean difference using Harris-Benedict = 14, P = .9273; mean difference using WHO = -13, P = .6215). CONCLUSION: Both energy prediction equations underestimated REE in children with sickle cell anemia. The 2 modified versions of the energy prediction equations that we propose predicted the energy needs of these children much more accurately; however, the modified equations need to be validated through application to other children with sickle cell anemia. SN - 0002-8223 UR - https://www.unboundmedicine.com/medline/citation/12146559/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-8223(02)90219-1 ER -