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Cryptococcus neoformans pulmonary granuloma formation is associated with matrix metalloproteinase-2 expression.
Med Mycol. 2002 Jun; 40(3):323-8.MM

Abstract

The aim of this study was to investigate matrix metalloproteinase (MMP) expression during the immune response to pulmonary Cryptococcus neoformans (Cne) infection. The immune response generated in C.B-17 and C57BL/6 mice to pulmonary Cne infection has previously been characterized as type 1 and type 2, respectively, differing in the cytokines produced and leukocytes recruited during infection, influencing the extent of Cne clearance from the lung. The focus of this study was to examine changes in expression of MMP-2 and tissue inhibitor of metalloproteinase (TIMP)-2 in the lungs of Cne-infected mice during the two types (type 1 vs. type 2) of responses. C.B-17 mice that formed well-defined granulomas had elevated levels of pulmonary MMP-2 mRNA early during infection. C57BL/6 mice that had poorly defined cellular aggregates did not express detectable levels of pulmonary MMP-2 mRNA until later in the infection. Specific expression of MMP/TIMP was correlated with the type of immune response present, resolution of Cne infection and the resulting lung pathology.

Authors+Show Affiliations

Majka SM
Children's Nutrition Research Center, Baylor College of Medicine, Houston, Texas, USA.
Kasimos J
No affiliation info available
Izzo L
No affiliation info available
Izzo AA
No affiliation info available

MeSH

AnimalsCryptococcosisCryptococcus neoformansDisease Models, AnimalGranuloma, Respiratory TractLeukocyte CountLungMatrix Metalloproteinase 2MiceMice, Inbred C57BLRNA, MessengerTime FactorsTissue Inhibitor of Metalloproteinase-2

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12146765

Citation

Majka, S M., et al. "Cryptococcus Neoformans Pulmonary Granuloma Formation Is Associated With Matrix Metalloproteinase-2 Expression." Medical Mycology, vol. 40, no. 3, 2002, pp. 323-8.
Majka SM, Kasimos J, Izzo L, et al. Cryptococcus neoformans pulmonary granuloma formation is associated with matrix metalloproteinase-2 expression. Med Mycol. 2002;40(3):323-8.
Majka, S. M., Kasimos, J., Izzo, L., & Izzo, A. A. (2002). Cryptococcus neoformans pulmonary granuloma formation is associated with matrix metalloproteinase-2 expression. Medical Mycology, 40(3), 323-8.
Majka SM, et al. Cryptococcus Neoformans Pulmonary Granuloma Formation Is Associated With Matrix Metalloproteinase-2 Expression. Med Mycol. 2002;40(3):323-8. PubMed PMID: 12146765.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cryptococcus neoformans pulmonary granuloma formation is associated with matrix metalloproteinase-2 expression. AU - Majka,S M, AU - Kasimos,J, AU - Izzo,L, AU - Izzo,A A, PY - 2002/7/31/pubmed PY - 2003/5/8/medline PY - 2002/7/31/entrez SP - 323 EP - 8 JF - Medical mycology JO - Med Mycol VL - 40 IS - 3 N2 - The aim of this study was to investigate matrix metalloproteinase (MMP) expression during the immune response to pulmonary Cryptococcus neoformans (Cne) infection. The immune response generated in C.B-17 and C57BL/6 mice to pulmonary Cne infection has previously been characterized as type 1 and type 2, respectively, differing in the cytokines produced and leukocytes recruited during infection, influencing the extent of Cne clearance from the lung. The focus of this study was to examine changes in expression of MMP-2 and tissue inhibitor of metalloproteinase (TIMP)-2 in the lungs of Cne-infected mice during the two types (type 1 vs. type 2) of responses. C.B-17 mice that formed well-defined granulomas had elevated levels of pulmonary MMP-2 mRNA early during infection. C57BL/6 mice that had poorly defined cellular aggregates did not express detectable levels of pulmonary MMP-2 mRNA until later in the infection. Specific expression of MMP/TIMP was correlated with the type of immune response present, resolution of Cne infection and the resulting lung pathology. SN - 1369-3786 UR - https://www.unboundmedicine.com/medline/citation/12146765/Cryptococcus_neoformans_pulmonary_granuloma_formation_is_associated_with_matrix_metalloproteinase_2_expression_ DB - PRIME DP - Unbound Medicine ER -