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[Prevention of periodontopathy and oral mucositis during antineoplastic chemotherapy. Clinical study].
Minerva Stomatol 2002; 51(6):231-9MS

Abstract

BACKGROUND

Oral mucositis is a common side effect of chemotherapy, with a multifactorial etiology: the direct toxicity of cancer therapy on the normal cells, reduced immunitary defences, presence of bacteria in the oral cavity. The aim of this study is to assess the clinical effectiveness of a preventive protocol of oral mucositis and periodontopathy during antineoplastic chemotherapy.

METHODS

The design of the study was a longitudinal evaluation of 30 patients undergoing antineoplastic chemotherapy at the out-patients Department of Oncology of the University of Sassari. The study lasted one year and was carried out at the Dentistry Department of the University of Sassari. The patients were motivated to home oral hygiene, underwent professional oral hygiene and clorexidine rinses were prescribed. Visible plaque index (VPI) and gingival bleeding index (GBI) were taken from each patient as periodontal indices, and the state of the mucosa was evaluated according to the WHO recommendations (1975). The control group was composed by 33 patients.

RESULTS

The values of the bleeding and plaque indices were considerably diminished between the first and the last visit, in nearly all the patients; the incidence of oral mucositis in the treated group was 20%, while in the control group it was 66%. 5-fluoruracil was always involved.

CONCLUSIONS

According to the results observed, the conclusion is drawn that the professional and home oral hygiene and the use of clorexidine, can reduce the incidence of oral mucositis as a side effect of antineoplastic chemotherapy.

Authors+Show Affiliations

Clinica Odontoiatrica, Università degli Studi di Sassari, Sassari, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

ita

PubMed ID

12147975

Citation

Lugliè, P F., et al. "[Prevention of Periodontopathy and Oral Mucositis During Antineoplastic Chemotherapy. Clinical Study]." Minerva Stomatologica, vol. 51, no. 6, 2002, pp. 231-9.
Lugliè PF, Mura G, Mura A, et al. [Prevention of periodontopathy and oral mucositis during antineoplastic chemotherapy. Clinical study]. Minerva Stomatol. 2002;51(6):231-9.
Lugliè, P. F., Mura, G., Mura, A., Angius, A., Soru, G., & Farris, A. (2002). [Prevention of periodontopathy and oral mucositis during antineoplastic chemotherapy. Clinical study]. Minerva Stomatologica, 51(6), pp. 231-9.
Lugliè PF, et al. [Prevention of Periodontopathy and Oral Mucositis During Antineoplastic Chemotherapy. Clinical Study]. Minerva Stomatol. 2002;51(6):231-9. PubMed PMID: 12147975.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Prevention of periodontopathy and oral mucositis during antineoplastic chemotherapy. Clinical study]. AU - Lugliè,P F, AU - Mura,G, AU - Mura,A, AU - Angius,A, AU - Soru,G, AU - Farris,A, PY - 2002/7/31/pubmed PY - 2003/1/16/medline PY - 2002/7/31/entrez SP - 231 EP - 9 JF - Minerva stomatologica JO - Minerva Stomatol VL - 51 IS - 6 N2 - BACKGROUND: Oral mucositis is a common side effect of chemotherapy, with a multifactorial etiology: the direct toxicity of cancer therapy on the normal cells, reduced immunitary defences, presence of bacteria in the oral cavity. The aim of this study is to assess the clinical effectiveness of a preventive protocol of oral mucositis and periodontopathy during antineoplastic chemotherapy. METHODS: The design of the study was a longitudinal evaluation of 30 patients undergoing antineoplastic chemotherapy at the out-patients Department of Oncology of the University of Sassari. The study lasted one year and was carried out at the Dentistry Department of the University of Sassari. The patients were motivated to home oral hygiene, underwent professional oral hygiene and clorexidine rinses were prescribed. Visible plaque index (VPI) and gingival bleeding index (GBI) were taken from each patient as periodontal indices, and the state of the mucosa was evaluated according to the WHO recommendations (1975). The control group was composed by 33 patients. RESULTS: The values of the bleeding and plaque indices were considerably diminished between the first and the last visit, in nearly all the patients; the incidence of oral mucositis in the treated group was 20%, while in the control group it was 66%. 5-fluoruracil was always involved. CONCLUSIONS: According to the results observed, the conclusion is drawn that the professional and home oral hygiene and the use of clorexidine, can reduce the incidence of oral mucositis as a side effect of antineoplastic chemotherapy. SN - 0026-4970 UR - https://www.unboundmedicine.com/medline/citation/12147975/[Prevention_of_periodontopathy_and_oral_mucositis_during_antineoplastic_chemotherapy__Clinical_study]_ DB - PRIME DP - Unbound Medicine ER -