Tags

Type your tag names separated by a space and hit enter

E2F-4 mutation in hereditary non-polyposis colorectal cancer.
J Exp Clin Cancer Res. 2002 Jun; 21(2):185-9.JE

Abstract

Defects in the DNA mismatch repair function are known to cause microsatellite instability (MSI) in hereditary non-polyposis colorectal cancer (HNPCC) as well as in a subset of sporadic colorectal cancer (CRC). We previously reported that the E2F-4 gene, which encodes an important transcription factor in cell cycle control, had frequent tumor-specific mutations at a coding region of trinucleotide microsatellite (CAG)n in a subset of human sporadic CRC with high-frequency MSI (MSI-H). In this study, we assessed mutations of E2F-4 in HNPCC as well as other target genes of defective DNA mismatch repair function. Eighteen colorectal cancer (CRC) patients from 13 kindreds meeting the Amsterdam criteria for HNPCC were analyzed and compared to sporadic CRC patients with MSI-H. We detected mutations of E2F-4 at the same repeat sequence in HNPCC. The frequency of the E2F-4 mutation in HNPCC was comparable with that in sporadic CRC with MSI-H. E2F-4 was considered to be one of the important target genes responsible for the carcinogenesis of HNPCC.

Authors+Show Affiliations

Dept. of Gastroenterological Surgery and Surgical Oncology, Okayama University Graduate School of Medicine, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12148576

Citation

Moriyama, H, et al. "E2F-4 Mutation in Hereditary Non-polyposis Colorectal Cancer." Journal of Experimental & Clinical Cancer Research : CR, vol. 21, no. 2, 2002, pp. 185-9.
Moriyama H, Sasamoto H, Kambara T, et al. E2F-4 mutation in hereditary non-polyposis colorectal cancer. J Exp Clin Cancer Res. 2002;21(2):185-9.
Moriyama, H., Sasamoto, H., Kambara, T., Matsubara, N., Ikeda, M., Baba, S., Meltzer, S. J., Lynch, H. T., Shimizu, K., & Tanaka, N. (2002). E2F-4 mutation in hereditary non-polyposis colorectal cancer. Journal of Experimental & Clinical Cancer Research : CR, 21(2), 185-9.
Moriyama H, et al. E2F-4 Mutation in Hereditary Non-polyposis Colorectal Cancer. J Exp Clin Cancer Res. 2002;21(2):185-9. PubMed PMID: 12148576.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - E2F-4 mutation in hereditary non-polyposis colorectal cancer. AU - Moriyama,H, AU - Sasamoto,H, AU - Kambara,T, AU - Matsubara,N, AU - Ikeda,M, AU - Baba,S, AU - Meltzer,S J, AU - Lynch,H T, AU - Shimizu,K, AU - Tanaka,N, PY - 2002/8/1/pubmed PY - 2003/1/29/medline PY - 2002/8/1/entrez SP - 185 EP - 9 JF - Journal of experimental & clinical cancer research : CR JO - J. Exp. Clin. Cancer Res. VL - 21 IS - 2 N2 - Defects in the DNA mismatch repair function are known to cause microsatellite instability (MSI) in hereditary non-polyposis colorectal cancer (HNPCC) as well as in a subset of sporadic colorectal cancer (CRC). We previously reported that the E2F-4 gene, which encodes an important transcription factor in cell cycle control, had frequent tumor-specific mutations at a coding region of trinucleotide microsatellite (CAG)n in a subset of human sporadic CRC with high-frequency MSI (MSI-H). In this study, we assessed mutations of E2F-4 in HNPCC as well as other target genes of defective DNA mismatch repair function. Eighteen colorectal cancer (CRC) patients from 13 kindreds meeting the Amsterdam criteria for HNPCC were analyzed and compared to sporadic CRC patients with MSI-H. We detected mutations of E2F-4 at the same repeat sequence in HNPCC. The frequency of the E2F-4 mutation in HNPCC was comparable with that in sporadic CRC with MSI-H. E2F-4 was considered to be one of the important target genes responsible for the carcinogenesis of HNPCC. SN - 0392-9078 UR - https://www.unboundmedicine.com/medline/citation/12148576/E2F_4_mutation_in_hereditary_non_polyposis_colorectal_cancer_ L2 - http://www.diseaseinfosearch.org/result/5249 DB - PRIME DP - Unbound Medicine ER -