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Amelioration of cisplatin induced nephrotoxicity in mice by ethyl acetate extract of a polypore fungus, Phellinus rimosus.
J Exp Clin Cancer Res. 2002 Jun; 21(2):213-7.JE

Abstract

Pretreatment of ethyl acetate extract of Phellinus rimosus (Berk) Pilat protected cisplatin induced nephrotoxicity in mice. Single dose of the extract (25 and 50 mg/kg body weight) decreased cisplatin induced serum creatinine and urea levels. The cisplatin depleted renal antioxidant defence system, such as activity of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX) and concentration of reduced glutathione (GSH), were restored by the treatment of the extract. The enhanced renal antioxidant defence system prevented cisplatin induced tissue lipid peroxidation. The experimental results suggest that ethyl acetate extract of P. rimosus protected cisplatin induced nephrotoxicity, possibly by enhancing renal antioxidant status. The extract did not interfere with the antitumor efficacy of cisplatin.

Authors+Show Affiliations

Amala Cancer Research Centre, Amala Nagar, Thrissur, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12148580

Citation

Ajith, T A., et al. "Amelioration of Cisplatin Induced Nephrotoxicity in Mice By Ethyl Acetate Extract of a Polypore Fungus, Phellinus Rimosus." Journal of Experimental & Clinical Cancer Research : CR, vol. 21, no. 2, 2002, pp. 213-7.
Ajith TA, Jose N, Janardhanan KK. Amelioration of cisplatin induced nephrotoxicity in mice by ethyl acetate extract of a polypore fungus, Phellinus rimosus. J Exp Clin Cancer Res. 2002;21(2):213-7.
Ajith, T. A., Jose, N., & Janardhanan, K. K. (2002). Amelioration of cisplatin induced nephrotoxicity in mice by ethyl acetate extract of a polypore fungus, Phellinus rimosus. Journal of Experimental & Clinical Cancer Research : CR, 21(2), 213-7.
Ajith TA, Jose N, Janardhanan KK. Amelioration of Cisplatin Induced Nephrotoxicity in Mice By Ethyl Acetate Extract of a Polypore Fungus, Phellinus Rimosus. J Exp Clin Cancer Res. 2002;21(2):213-7. PubMed PMID: 12148580.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Amelioration of cisplatin induced nephrotoxicity in mice by ethyl acetate extract of a polypore fungus, Phellinus rimosus. AU - Ajith,T A, AU - Jose,Nayana, AU - Janardhanan,K K, PY - 2002/8/1/pubmed PY - 2003/1/29/medline PY - 2002/8/1/entrez SP - 213 EP - 7 JF - Journal of experimental & clinical cancer research : CR JO - J Exp Clin Cancer Res VL - 21 IS - 2 N2 - Pretreatment of ethyl acetate extract of Phellinus rimosus (Berk) Pilat protected cisplatin induced nephrotoxicity in mice. Single dose of the extract (25 and 50 mg/kg body weight) decreased cisplatin induced serum creatinine and urea levels. The cisplatin depleted renal antioxidant defence system, such as activity of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX) and concentration of reduced glutathione (GSH), were restored by the treatment of the extract. The enhanced renal antioxidant defence system prevented cisplatin induced tissue lipid peroxidation. The experimental results suggest that ethyl acetate extract of P. rimosus protected cisplatin induced nephrotoxicity, possibly by enhancing renal antioxidant status. The extract did not interfere with the antitumor efficacy of cisplatin. SN - 0392-9078 UR - https://www.unboundmedicine.com/medline/citation/12148580/Amelioration_of_cisplatin_induced_nephrotoxicity_in_mice_by_ethyl_acetate_extract_of_a_polypore_fungus_Phellinus_rimosus_ L2 - https://medlineplus.gov/kidneydiseases.html DB - PRIME DP - Unbound Medicine ER -