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Considerations and development of topical microbicides to inhibit the sexual transmission of HIV.
Expert Opin Investig Drugs. 2002 Aug; 11(8):1077-97.EO

Abstract

The increased incidence of HIV/AIDS disease in women aged 15 - 49 years has identified the urgent need for a female-controlled, efficacious and safe vaginal topical microbicide. To meet this challenge, new topical microbicide candidates consisting of molecules or formulations that modify the genital environment (BufferGel, engineered Lactobacillus, over-the-counter lubricants), surfactants (C31D/Savvy, sodium dodecyl sulfate, sodium lauryl sulfate), polyanionic polymers (PRO 2000, beta-cyclodextrin, Carraguard, CAP, D2S, SPL-7013), proteins (cyanovirin-N, monoclonal antibodies, thromspondin-1 peptides, Pokeweed antiviral protein and others), reverse transcription inhibitors (PMPA [Tenofovir ]), UC-781, SJ-3366, DABO and thiourea) and other molecules (NCp7-specific virucides, chemokine receptor agonists/antagonists, WHI-05 and WHI-07) are currently being investigated for activity, safety and efficacy. This review will assess the development of these molecules in the context of cervicovaginal defences and the clinical failure of nonoxynol-9.

Authors+Show Affiliations

TherImmune Research Corporation, Infectious Disease and Immunology Department, 18761 North Frederick Avenue, Suite A, Gaithersburg, MD 20879, USA. jturpin@therimmune.come

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

12150703

Citation

Turpin, Jim A.. "Considerations and Development of Topical Microbicides to Inhibit the Sexual Transmission of HIV." Expert Opinion On Investigational Drugs, vol. 11, no. 8, 2002, pp. 1077-97.
Turpin JA. Considerations and development of topical microbicides to inhibit the sexual transmission of HIV. Expert Opin Investig Drugs. 2002;11(8):1077-97.
Turpin, J. A. (2002). Considerations and development of topical microbicides to inhibit the sexual transmission of HIV. Expert Opinion On Investigational Drugs, 11(8), 1077-97.
Turpin JA. Considerations and Development of Topical Microbicides to Inhibit the Sexual Transmission of HIV. Expert Opin Investig Drugs. 2002;11(8):1077-97. PubMed PMID: 12150703.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Considerations and development of topical microbicides to inhibit the sexual transmission of HIV. A1 - Turpin,Jim A, PY - 2002/8/2/pubmed PY - 2003/2/14/medline PY - 2002/8/2/entrez SP - 1077 EP - 97 JF - Expert opinion on investigational drugs JO - Expert Opin Investig Drugs VL - 11 IS - 8 N2 - The increased incidence of HIV/AIDS disease in women aged 15 - 49 years has identified the urgent need for a female-controlled, efficacious and safe vaginal topical microbicide. To meet this challenge, new topical microbicide candidates consisting of molecules or formulations that modify the genital environment (BufferGel, engineered Lactobacillus, over-the-counter lubricants), surfactants (C31D/Savvy, sodium dodecyl sulfate, sodium lauryl sulfate), polyanionic polymers (PRO 2000, beta-cyclodextrin, Carraguard, CAP, D2S, SPL-7013), proteins (cyanovirin-N, monoclonal antibodies, thromspondin-1 peptides, Pokeweed antiviral protein and others), reverse transcription inhibitors (PMPA [Tenofovir ]), UC-781, SJ-3366, DABO and thiourea) and other molecules (NCp7-specific virucides, chemokine receptor agonists/antagonists, WHI-05 and WHI-07) are currently being investigated for activity, safety and efficacy. This review will assess the development of these molecules in the context of cervicovaginal defences and the clinical failure of nonoxynol-9. SN - 1354-3784 UR - https://www.unboundmedicine.com/medline/citation/12150703/Considerations_and_development_of_topical_microbicides_to_inhibit_the_sexual_transmission_of_HIV_ L2 - https://www.tandfonline.com/doi/full/10.1517/13543784.11.8.1077 DB - PRIME DP - Unbound Medicine ER -