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[Effect of erythropoietin therapy on serum lipoprotein levels in patients on hemodialysis].
Lijec Vjesn. 2002 May; 124(5):146-50.LV

Abstract

Disturbed lipoprotein metabolism is a well-documented feature in hemodialysis (HD) patients, and lipoprotein disturbances have been clearly linked to premature cardiovascular disease. The aim of this prospective study was to evaluate whether recombinant human erythropoietin (rHuEpo) therapy affects lipid metabolism. The study was performed in 40 chronic HD patients treated for three years with rHuEpo subcutaneously at the end of each dialysis session. Target hemoglobin (Hb) was 110 g/L. The control group consisted of 20 matched HD patients not treated with rHuEpo. Total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, apolipoprotein A1 and B as well as lipoprotein (a) were assessed at baseline (without rHuEpo) and at months 6, 12, 18, 24, 30 and 36. In rHuEpo treated group a significant decrease in total cholesterol (6.05 +/- 1.0 vs. 5.15 +/- 0.6 mmol/L; p < 0.05), LDL-cholesterol (3.5 +/- 0.5 vs. 3.08 +/- 0.4 mmol/L; p < 0.05), apoprotein B (1.17 +/- 0.07 vs. 1.12 +/- 0.06 g/L; p < 0.05) and serum triglycerides (2.37 +/- 0.6 vs. 2.0 +/- 0.4 mmol/L; p < 0.05) and a significant increase in HDL-cholesterol (0.88 +/- 0.2 vs. 1.08 +/- 0.2 mmol/L; p < 0.05) occurred during the study. The improvement in each of the lipid parameters correlated significantly (p < 0.05) with the increase in Hb. It could be concluded that long-term rHuEpo treatment is associated with an improvement in the lipid profile. These results suggest that the high incidence of cardiovascular diseases in HD patients might be reduced with rHuEpo therapy.

Authors+Show Affiliations

Zavod za nefrologiju i dijalizu, Klinika za unutarnje bolesti Klinicke bolnice Sestre milosrdnice, Zagreb.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

hrv

PubMed ID

12152415

Citation

Kes, Petar, et al. "[Effect of Erythropoietin Therapy On Serum Lipoprotein Levels in Patients On Hemodialysis]." Lijecnicki Vjesnik, vol. 124, no. 5, 2002, pp. 146-50.
Kes P, Bobić I, Reiner Z, et al. [Effect of erythropoietin therapy on serum lipoprotein levels in patients on hemodialysis]. Lijec Vjesn. 2002;124(5):146-50.
Kes, P., Bobić, I., Reiner, Z., & Ratković-Gusić, I. (2002). [Effect of erythropoietin therapy on serum lipoprotein levels in patients on hemodialysis]. Lijecnicki Vjesnik, 124(5), 146-50.
Kes P, et al. [Effect of Erythropoietin Therapy On Serum Lipoprotein Levels in Patients On Hemodialysis]. Lijec Vjesn. 2002;124(5):146-50. PubMed PMID: 12152415.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effect of erythropoietin therapy on serum lipoprotein levels in patients on hemodialysis]. AU - Kes,Petar, AU - Bobić,Indira, AU - Reiner,Zeljko, AU - Ratković-Gusić,Iva, PY - 2002/8/3/pubmed PY - 2002/8/29/medline PY - 2002/8/3/entrez SP - 146 EP - 50 JF - Lijecnicki vjesnik JO - Lijec Vjesn VL - 124 IS - 5 N2 - Disturbed lipoprotein metabolism is a well-documented feature in hemodialysis (HD) patients, and lipoprotein disturbances have been clearly linked to premature cardiovascular disease. The aim of this prospective study was to evaluate whether recombinant human erythropoietin (rHuEpo) therapy affects lipid metabolism. The study was performed in 40 chronic HD patients treated for three years with rHuEpo subcutaneously at the end of each dialysis session. Target hemoglobin (Hb) was 110 g/L. The control group consisted of 20 matched HD patients not treated with rHuEpo. Total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, apolipoprotein A1 and B as well as lipoprotein (a) were assessed at baseline (without rHuEpo) and at months 6, 12, 18, 24, 30 and 36. In rHuEpo treated group a significant decrease in total cholesterol (6.05 +/- 1.0 vs. 5.15 +/- 0.6 mmol/L; p < 0.05), LDL-cholesterol (3.5 +/- 0.5 vs. 3.08 +/- 0.4 mmol/L; p < 0.05), apoprotein B (1.17 +/- 0.07 vs. 1.12 +/- 0.06 g/L; p < 0.05) and serum triglycerides (2.37 +/- 0.6 vs. 2.0 +/- 0.4 mmol/L; p < 0.05) and a significant increase in HDL-cholesterol (0.88 +/- 0.2 vs. 1.08 +/- 0.2 mmol/L; p < 0.05) occurred during the study. The improvement in each of the lipid parameters correlated significantly (p < 0.05) with the increase in Hb. It could be concluded that long-term rHuEpo treatment is associated with an improvement in the lipid profile. These results suggest that the high incidence of cardiovascular diseases in HD patients might be reduced with rHuEpo therapy. SN - 0024-3477 UR - https://www.unboundmedicine.com/medline/citation/12152415/[Effect_of_erythropoietin_therapy_on_serum_lipoprotein_levels_in_patients_on_hemodialysis]_ L2 - https://medlineplus.gov/dialysis.html DB - PRIME DP - Unbound Medicine ER -