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Isoflavones from red clover (Promensil) significantly reduce menopausal hot flush symptoms compared with placebo.
Maturitas 2002; 42(3):187-93M

Abstract

OBJECTIVES

To investigate the effectiveness and safety of a red clover isoflavone dietary supplement (Promensil, Novogen Ltd., Australia) versus placebo on the change in hot flush frequency in postmenopausal women.

METHODS

In this randomized, double blind, placebo-controlled trial 30 women with more than 12 months amenorrhoea and experiencing more than five flushes per day were enrolled. All received single blind placebo tablets for 4 weeks and were subsequently randomized to either placebo or 80 mg isoflavones for a further 12 weeks. Efficacy was measured by the decrease in number of hot flushes per day and changes in Greene Climacteric Scale Score.

RESULTS

During the first 4 weeks of placebo the frequency of hot flushes decreased by 16%. During the subsequent double blind phase, a further, statistically significant decrease of 44% was seen in isoflavones group (P<0.01), whereas no further reduction occurred within the placebo group. The Greene score decreased in the active group by 13% and remained unchanged in the placebo group.

CONCLUSION

In this study, treatment with 80 mg isoflavones (Promensil) per day resulted in a significant reduction in hot flushes from baseline. At the end of the study there was a significant decrease in hot flushes of 44% between the active and placebo group, demonstrating the effectiveness of Promensil in the management of hot flushes.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands.No affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12161042

Citation

van de Weijer, Peter H M., and Ronald Barentsen. "Isoflavones From Red Clover (Promensil) Significantly Reduce Menopausal Hot Flush Symptoms Compared With Placebo." Maturitas, vol. 42, no. 3, 2002, pp. 187-93.
van de Weijer PH, Barentsen R. Isoflavones from red clover (Promensil) significantly reduce menopausal hot flush symptoms compared with placebo. Maturitas. 2002;42(3):187-93.
van de Weijer, P. H., & Barentsen, R. (2002). Isoflavones from red clover (Promensil) significantly reduce menopausal hot flush symptoms compared with placebo. Maturitas, 42(3), pp. 187-93.
van de Weijer PH, Barentsen R. Isoflavones From Red Clover (Promensil) Significantly Reduce Menopausal Hot Flush Symptoms Compared With Placebo. Maturitas. 2002 Jul 25;42(3):187-93. PubMed PMID: 12161042.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Isoflavones from red clover (Promensil) significantly reduce menopausal hot flush symptoms compared with placebo. AU - van de Weijer,Peter H M, AU - Barentsen,Ronald, PY - 2002/8/6/pubmed PY - 2003/6/11/medline PY - 2002/8/6/entrez SP - 187 EP - 93 JF - Maturitas JO - Maturitas VL - 42 IS - 3 N2 - OBJECTIVES: To investigate the effectiveness and safety of a red clover isoflavone dietary supplement (Promensil, Novogen Ltd., Australia) versus placebo on the change in hot flush frequency in postmenopausal women. METHODS: In this randomized, double blind, placebo-controlled trial 30 women with more than 12 months amenorrhoea and experiencing more than five flushes per day were enrolled. All received single blind placebo tablets for 4 weeks and were subsequently randomized to either placebo or 80 mg isoflavones for a further 12 weeks. Efficacy was measured by the decrease in number of hot flushes per day and changes in Greene Climacteric Scale Score. RESULTS: During the first 4 weeks of placebo the frequency of hot flushes decreased by 16%. During the subsequent double blind phase, a further, statistically significant decrease of 44% was seen in isoflavones group (P<0.01), whereas no further reduction occurred within the placebo group. The Greene score decreased in the active group by 13% and remained unchanged in the placebo group. CONCLUSION: In this study, treatment with 80 mg isoflavones (Promensil) per day resulted in a significant reduction in hot flushes from baseline. At the end of the study there was a significant decrease in hot flushes of 44% between the active and placebo group, demonstrating the effectiveness of Promensil in the management of hot flushes. SN - 0378-5122 UR - https://www.unboundmedicine.com/medline/citation/12161042/Isoflavones_from_red_clover__Promensil__significantly_reduce_menopausal_hot_flush_symptoms_compared_with_placebo_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378512202000804 DB - PRIME DP - Unbound Medicine ER -