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Tolerability and safety profile of sildenafil citrate (Viagra) in Latin American patient populations.
Int J Impot Res. 2002 Aug; 14 Suppl 2:S54-9.IJ

Abstract

Safety data from 546 men with erectile dysfunction (ED) enrolled in three double-blind, placebo-controlled studies conducted in distinct regions of Latin America were pooled and analyzed. The most commonly reported adverse events of all causalities associated with sildenafil treatment were headache (19%), flushing (14%), dyspepsia (6%), and nasal congestion (4%), reflecting the inhibitory effects of sildenafil on cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) in the peripheral vasculature, gastroesophageal sphincter, and nasal mucosa. Visual symptoms were reported in 5.5%, reflecting sildenafil's minor inhibitory effects on cGMP-specific PDE6 in the retina. These adverse events were generally transient and mild, and rarely resulted in discontinuation of sildenafil therapy. Thus, in this representative sample of Latin American men with ED, including those with concomitant stable cardiovascular disease, sildenafil treatment was well tolerated with an incident rate of adverse events similar to reports from other patient populations.

Authors+Show Affiliations

Department of Cardiology, University Hospital-University of Campinas, Sao Paolo, Brazil. otaviocoelho@uol.com.br

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

12161769

Citation

Coelho, O R.. "Tolerability and Safety Profile of Sildenafil Citrate (Viagra) in Latin American Patient Populations." International Journal of Impotence Research, vol. 14 Suppl 2, 2002, pp. S54-9.
Coelho OR. Tolerability and safety profile of sildenafil citrate (Viagra) in Latin American patient populations. Int J Impot Res. 2002;14 Suppl 2:S54-9.
Coelho, O. R. (2002). Tolerability and safety profile of sildenafil citrate (Viagra) in Latin American patient populations. International Journal of Impotence Research, 14 Suppl 2, S54-9.
Coelho OR. Tolerability and Safety Profile of Sildenafil Citrate (Viagra) in Latin American Patient Populations. Int J Impot Res. 2002;14 Suppl 2:S54-9. PubMed PMID: 12161769.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tolerability and safety profile of sildenafil citrate (Viagra) in Latin American patient populations. A1 - Coelho,O R, PY - 2002/8/6/pubmed PY - 2003/1/23/medline PY - 2002/8/6/entrez SP - S54 EP - 9 JF - International journal of impotence research JO - Int. J. Impot. Res. VL - 14 Suppl 2 N2 - Safety data from 546 men with erectile dysfunction (ED) enrolled in three double-blind, placebo-controlled studies conducted in distinct regions of Latin America were pooled and analyzed. The most commonly reported adverse events of all causalities associated with sildenafil treatment were headache (19%), flushing (14%), dyspepsia (6%), and nasal congestion (4%), reflecting the inhibitory effects of sildenafil on cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) in the peripheral vasculature, gastroesophageal sphincter, and nasal mucosa. Visual symptoms were reported in 5.5%, reflecting sildenafil's minor inhibitory effects on cGMP-specific PDE6 in the retina. These adverse events were generally transient and mild, and rarely resulted in discontinuation of sildenafil therapy. Thus, in this representative sample of Latin American men with ED, including those with concomitant stable cardiovascular disease, sildenafil treatment was well tolerated with an incident rate of adverse events similar to reports from other patient populations. SN - 0955-9930 UR - https://www.unboundmedicine.com/medline/citation/12161769/Tolerability_and_safety_profile_of_sildenafil_citrate__Viagra__in_Latin_American_patient_populations_ L2 - http://dx.doi.org/10.1038/sj.ijir.3900899 DB - PRIME DP - Unbound Medicine ER -