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Two polymorphisms in the vitamin D receptor gene--association with bone mass and 5-year change in bone mass with or without hormone-replacement therapy in postmenopausal women: the Danish Osteoporosis Prevention Study.
J Bone Miner Res. 2002 Aug; 17(8):1535-44.JB

Abstract

The significance of an interrelation between nongenetic factors and genotype effects in the regulation of bone mass is not clear. In this prospective study of 429 healthy early postmenopausal Danish women, we investigated the association between bone mineral density (BMD) and the FokI and BsmI polymorphisms in the vitamin D receptor (VDR) gene. Participants were allocated to either hormone-replacement therapy (HRT) or no treatment by randomization or personal choice. After 5 years, 332 women with unchanged treatment status were available for analyses, 98 of these women were still on HRT. No association with initial BMD or 5-year change in BMD was found for either polymorphism. In women with body mass index (BMI) < 25 (n = 282), the f allele was associated with lower BMD of the hip (p < 0.001) and forearm (p = 0.001), and the b allele was associated with lower spine BMD (p = 0.02). Comparing thin/normal weight women with overweight/ obese women of the same genotype, FF women had similar BMD at all measured sites in contrast to Ff and ff women in whom BMD, as expected, was higher in the overweight/obese women. Similar results were found for the BsmI polymorphism with no difference in BMD between BMI groups in BB women. Segregation into groups according to dietary calcium intake did not reveal any genotype association with BMD. These results provide some evidence of a modifying effect of nongenetic factors, specifically BMI, on the association between VDR genotype and BMD. High BMI may protect against lower BMD seen in association with thef or b alleles. In some genotypes (FF and BB), BMI had relatively little effect on BMD.

Authors+Show Affiliations

Department 545, The Osteoporosis Research Clinic, Hvidovre Hospital, Denmark.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12162507

Citation

Tofteng, C L., et al. "Two Polymorphisms in the Vitamin D Receptor Gene--association With Bone Mass and 5-year Change in Bone Mass With or Without Hormone-replacement Therapy in Postmenopausal Women: the Danish Osteoporosis Prevention Study." Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, vol. 17, no. 8, 2002, pp. 1535-44.
Tofteng CL, Jensen JE, Abrahamsen B, et al. Two polymorphisms in the vitamin D receptor gene--association with bone mass and 5-year change in bone mass with or without hormone-replacement therapy in postmenopausal women: the Danish Osteoporosis Prevention Study. J Bone Miner Res. 2002;17(8):1535-44.
Tofteng, C. L., Jensen, J. E., Abrahamsen, B., Odum, L., & Brot, C. (2002). Two polymorphisms in the vitamin D receptor gene--association with bone mass and 5-year change in bone mass with or without hormone-replacement therapy in postmenopausal women: the Danish Osteoporosis Prevention Study. Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, 17(8), 1535-44.
Tofteng CL, et al. Two Polymorphisms in the Vitamin D Receptor Gene--association With Bone Mass and 5-year Change in Bone Mass With or Without Hormone-replacement Therapy in Postmenopausal Women: the Danish Osteoporosis Prevention Study. J Bone Miner Res. 2002;17(8):1535-44. PubMed PMID: 12162507.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Two polymorphisms in the vitamin D receptor gene--association with bone mass and 5-year change in bone mass with or without hormone-replacement therapy in postmenopausal women: the Danish Osteoporosis Prevention Study. AU - Tofteng,C L, AU - Jensen,J E B, AU - Abrahamsen,B, AU - Odum,L, AU - Brot,C, PY - 2002/8/7/pubmed PY - 2003/1/23/medline PY - 2002/8/7/entrez SP - 1535 EP - 44 JF - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research JO - J Bone Miner Res VL - 17 IS - 8 N2 - The significance of an interrelation between nongenetic factors and genotype effects in the regulation of bone mass is not clear. In this prospective study of 429 healthy early postmenopausal Danish women, we investigated the association between bone mineral density (BMD) and the FokI and BsmI polymorphisms in the vitamin D receptor (VDR) gene. Participants were allocated to either hormone-replacement therapy (HRT) or no treatment by randomization or personal choice. After 5 years, 332 women with unchanged treatment status were available for analyses, 98 of these women were still on HRT. No association with initial BMD or 5-year change in BMD was found for either polymorphism. In women with body mass index (BMI) < 25 (n = 282), the f allele was associated with lower BMD of the hip (p < 0.001) and forearm (p = 0.001), and the b allele was associated with lower spine BMD (p = 0.02). Comparing thin/normal weight women with overweight/ obese women of the same genotype, FF women had similar BMD at all measured sites in contrast to Ff and ff women in whom BMD, as expected, was higher in the overweight/obese women. Similar results were found for the BsmI polymorphism with no difference in BMD between BMI groups in BB women. Segregation into groups according to dietary calcium intake did not reveal any genotype association with BMD. These results provide some evidence of a modifying effect of nongenetic factors, specifically BMI, on the association between VDR genotype and BMD. High BMI may protect against lower BMD seen in association with thef or b alleles. In some genotypes (FF and BB), BMI had relatively little effect on BMD. SN - 0884-0431 UR - https://www.unboundmedicine.com/medline/citation/12162507/Two_polymorphisms_in_the_vitamin_D_receptor_gene__association_with_bone_mass_and_5_year_change_in_bone_mass_with_or_without_hormone_replacement_therapy_in_postmenopausal_women:_the_Danish_Osteoporosis_Prevention_Study_ L2 - https://doi.org/10.1359/jbmr.2002.17.8.1535 DB - PRIME DP - Unbound Medicine ER -