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Caloric intake and the risk of Alzheimer disease.
Arch Neurol 2002; 59(8):1258-63AN

Abstract

BACKGROUND

Diet may play a role in Alzheimer disease (AD).

OBJECTIVE

To examine the association between caloric intake and AD.

METHODS

Elderly individuals free of dementia at baseline (N = 980) were followed for a mean of 4 years. Daily intake of calories, carbohydrates, fats, and protein were recalled using a semiquantitative food frequency questionnaire administered between the baseline and first follow-up visits. Proportional hazards models were used to examine the associations of quartiles of intake and incident AD, adjusting for confounders.

RESULTS

There were 242 incident cases of AD during 4023 years of follow-up (6 cases per 100 person-years). Compared with individuals in the lowest quartile of caloric intake, those in the highest quartile had an increased risk of AD (hazard ratio, 1.5; 95% confidence interval [CI], 1.0-2.2). Among individuals with the apolipoprotein E epsilon4 allele, the hazard ratios of AD for the highest quartiles of calorie and fat intake were 2.3 (95% CI, 1.1-4.7) and 2.3 (95% CI, 1.1-4.9), respectively, compared with the lowest quartiles. The hazard ratios of AD for the highest quartiles of calorie and fat intake compared with the lowest quartiles in individuals without the apolipoprotein E epsilon4 allele were close to 1 and were not statistically significant (P =.83 and P =.61, respectively).

CONCLUSION

Higher intake of calories and fats may be associated with higher risk of AD in individuals carrying the apolipoprotein E epsilon4 allele.

Authors+Show Affiliations

Taub Institute for Research of Alzheimer's Disease and the Aging Brain, Columbia University, 630 W 168th St, New York, NY 10032, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12164721

Citation

Luchsinger, Jose A., et al. "Caloric Intake and the Risk of Alzheimer Disease." Archives of Neurology, vol. 59, no. 8, 2002, pp. 1258-63.
Luchsinger JA, Tang MX, Shea S, et al. Caloric intake and the risk of Alzheimer disease. Arch Neurol. 2002;59(8):1258-63.
Luchsinger, J. A., Tang, M. X., Shea, S., & Mayeux, R. (2002). Caloric intake and the risk of Alzheimer disease. Archives of Neurology, 59(8), pp. 1258-63.
Luchsinger JA, et al. Caloric Intake and the Risk of Alzheimer Disease. Arch Neurol. 2002;59(8):1258-63. PubMed PMID: 12164721.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Caloric intake and the risk of Alzheimer disease. AU - Luchsinger,Jose A, AU - Tang,Ming-Xing, AU - Shea,Steven, AU - Mayeux,Richard, PY - 2002/8/8/pubmed PY - 2002/8/31/medline PY - 2002/8/8/entrez SP - 1258 EP - 63 JF - Archives of neurology JO - Arch. Neurol. VL - 59 IS - 8 N2 - BACKGROUND: Diet may play a role in Alzheimer disease (AD). OBJECTIVE: To examine the association between caloric intake and AD. METHODS: Elderly individuals free of dementia at baseline (N = 980) were followed for a mean of 4 years. Daily intake of calories, carbohydrates, fats, and protein were recalled using a semiquantitative food frequency questionnaire administered between the baseline and first follow-up visits. Proportional hazards models were used to examine the associations of quartiles of intake and incident AD, adjusting for confounders. RESULTS: There were 242 incident cases of AD during 4023 years of follow-up (6 cases per 100 person-years). Compared with individuals in the lowest quartile of caloric intake, those in the highest quartile had an increased risk of AD (hazard ratio, 1.5; 95% confidence interval [CI], 1.0-2.2). Among individuals with the apolipoprotein E epsilon4 allele, the hazard ratios of AD for the highest quartiles of calorie and fat intake were 2.3 (95% CI, 1.1-4.7) and 2.3 (95% CI, 1.1-4.9), respectively, compared with the lowest quartiles. The hazard ratios of AD for the highest quartiles of calorie and fat intake compared with the lowest quartiles in individuals without the apolipoprotein E epsilon4 allele were close to 1 and were not statistically significant (P =.83 and P =.61, respectively). CONCLUSION: Higher intake of calories and fats may be associated with higher risk of AD in individuals carrying the apolipoprotein E epsilon4 allele. SN - 0003-9942 UR - https://www.unboundmedicine.com/medline/citation/12164721/Caloric_intake_and_the_risk_of_Alzheimer_disease_ L2 - https://jamanetwork.com/journals/jamaneurology/fullarticle/vol/59/pg/1258 DB - PRIME DP - Unbound Medicine ER -