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No antioxidant effect of combined HRT on LDL oxidizability and oxidative stress biomarkers in treated post-menopausal women.
J Am Coll Nutr 2002; 21(4):333-8JA

Abstract

OBJECTIVE

To compare oxidative stress and LDL oxidizability in postmenopausal women with and without HRT.

METHODS

In a cross sectional study, two groups of women, with or without combined per os HRT (1.5-2 mg estrogen associated with 10 mg dydrogesteron), were age and duration of menopause matched. Women were recruited after medical examination at LBSO (Oxidative Stress Laboratory), Joseph Fourier University, Grenoble, and Department of Gynecology, Grenoble University Hospital, France. Main outcome measures included determination of lipid profile and oxidative stress biomarkers (TBARS, LDL oxidizability, autoantibodies against oxidized-LDL). Measurement of circulating levels of vitamin C, E, beta-carotene, lycopene and total antioxidant plasma capacity.

RESULTS

HRT led to decreased plasma total and LDL cholesterol (p < 0.05), but did not affect oxidizability and oxidation of LDL. Circulating levels of antioxidant vitamins (beta-carotene, vitamin C, vitamin E/triglycerides) and total antioxidant capacity of plasma and lipid peroxidation, assessed by plasma TBARs, were not different from controls in postmenopausal women receiving HRT.

CONCLUSION

This study suggests that even if combined HRT modifies the blood lipid profile, it does not appear to influence oxidative status.

Authors+Show Affiliations

LBSO, University J. Fourier, Domaine de la Merci, La Tronche, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12166530

Citation

Bureau, Isabelle, et al. "No Antioxidant Effect of Combined HRT On LDL Oxidizability and Oxidative Stress Biomarkers in Treated Post-menopausal Women." Journal of the American College of Nutrition, vol. 21, no. 4, 2002, pp. 333-8.
Bureau I, Laporte F, Favier M, et al. No antioxidant effect of combined HRT on LDL oxidizability and oxidative stress biomarkers in treated post-menopausal women. J Am Coll Nutr. 2002;21(4):333-8.
Bureau, I., Laporte, F., Favier, M., Faure, H., Fields, M., Favier, A. E., & Roussel, A. M. (2002). No antioxidant effect of combined HRT on LDL oxidizability and oxidative stress biomarkers in treated post-menopausal women. Journal of the American College of Nutrition, 21(4), pp. 333-8.
Bureau I, et al. No Antioxidant Effect of Combined HRT On LDL Oxidizability and Oxidative Stress Biomarkers in Treated Post-menopausal Women. J Am Coll Nutr. 2002;21(4):333-8. PubMed PMID: 12166530.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - No antioxidant effect of combined HRT on LDL oxidizability and oxidative stress biomarkers in treated post-menopausal women. AU - Bureau,Isabelle, AU - Laporte,François, AU - Favier,Max, AU - Faure,Henri, AU - Fields,Meira, AU - Favier,Alain E, AU - Roussel,Anne-Marie, PY - 2002/8/9/pubmed PY - 2003/3/26/medline PY - 2002/8/9/entrez SP - 333 EP - 8 JF - Journal of the American College of Nutrition JO - J Am Coll Nutr VL - 21 IS - 4 N2 - OBJECTIVE: To compare oxidative stress and LDL oxidizability in postmenopausal women with and without HRT. METHODS: In a cross sectional study, two groups of women, with or without combined per os HRT (1.5-2 mg estrogen associated with 10 mg dydrogesteron), were age and duration of menopause matched. Women were recruited after medical examination at LBSO (Oxidative Stress Laboratory), Joseph Fourier University, Grenoble, and Department of Gynecology, Grenoble University Hospital, France. Main outcome measures included determination of lipid profile and oxidative stress biomarkers (TBARS, LDL oxidizability, autoantibodies against oxidized-LDL). Measurement of circulating levels of vitamin C, E, beta-carotene, lycopene and total antioxidant plasma capacity. RESULTS: HRT led to decreased plasma total and LDL cholesterol (p < 0.05), but did not affect oxidizability and oxidation of LDL. Circulating levels of antioxidant vitamins (beta-carotene, vitamin C, vitamin E/triglycerides) and total antioxidant capacity of plasma and lipid peroxidation, assessed by plasma TBARs, were not different from controls in postmenopausal women receiving HRT. CONCLUSION: This study suggests that even if combined HRT modifies the blood lipid profile, it does not appear to influence oxidative status. SN - 0731-5724 UR - https://www.unboundmedicine.com/medline/citation/12166530/No_antioxidant_effect_of_combined_HRT_on_LDL_oxidizability_and_oxidative_stress_biomarkers_in_treated_post_menopausal_women_ L2 - http://www.tandfonline.com/doi/full/10.1080/07315724.2002.10719231 DB - PRIME DP - Unbound Medicine ER -