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Vitamin E and neurodegenerative disorders associated with oxidative stress.
Nutr Neurosci. 2002 Sep; 5(4):229-39.NN

Abstract

Several neurodegenerative disorders are associated with oxidative stress that is manifested by lipid peroxidation, protein oxidation and other markers. Included in these disorders in which oxidative stress is thought to play an important role in their pathogenesis are Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), tardive dyskinesia, Huntington's disease (HD), and multiple sclerosis. This review presents some of the chemistry of vitamin E as an antioxidant and summarizes studies in which vitamin E has been employed in these disorders and models thereof.

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Authors+Show Affiliations

Butterfield DA
Department of Chemistry, Center of Membrane Sciences, and Sanders-Brown Center on Aging, University of Kentucky, Lexington 40506, USA. dabcns@uky.edu
Castegna A
No affiliation info available
Drake J
No affiliation info available
Scapagnini G
No affiliation info available
Calabrese V
No affiliation info available

MeSH

Alzheimer DiseaseAmyotrophic Lateral SclerosisBiological AvailabilityDyskinesiasHumansHuntington DiseaseIntestinal AbsorptionLipid PeroxidationMultiple SclerosisNeurodegenerative DiseasesOxidative StressParkinson DiseaseVitamin E

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

12168685

Citation

Butterfield, D Allan, et al. "Vitamin E and Neurodegenerative Disorders Associated With Oxidative Stress." Nutritional Neuroscience, vol. 5, no. 4, 2002, pp. 229-39.
Butterfield DA, Castegna A, Drake J, et al. Vitamin E and neurodegenerative disorders associated with oxidative stress. Nutr Neurosci. 2002;5(4):229-39.
Butterfield, D. A., Castegna, A., Drake, J., Scapagnini, G., & Calabrese, V. (2002). Vitamin E and neurodegenerative disorders associated with oxidative stress. Nutritional Neuroscience, 5(4), 229-39.
Butterfield DA, et al. Vitamin E and Neurodegenerative Disorders Associated With Oxidative Stress. Nutr Neurosci. 2002;5(4):229-39. PubMed PMID: 12168685.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin E and neurodegenerative disorders associated with oxidative stress. AU - Butterfield,D Allan, AU - Castegna,Alessandra, AU - Drake,Jennifer, AU - Scapagnini,Giovanni, AU - Calabrese,Vittorio, PY - 2002/8/10/pubmed PY - 2003/1/25/medline PY - 2002/8/10/entrez SP - 229 EP - 39 JF - Nutritional neuroscience JO - Nutr Neurosci VL - 5 IS - 4 N2 - Several neurodegenerative disorders are associated with oxidative stress that is manifested by lipid peroxidation, protein oxidation and other markers. Included in these disorders in which oxidative stress is thought to play an important role in their pathogenesis are Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), tardive dyskinesia, Huntington's disease (HD), and multiple sclerosis. This review presents some of the chemistry of vitamin E as an antioxidant and summarizes studies in which vitamin E has been employed in these disorders and models thereof. SN - 1028-415X UR - https://www.unboundmedicine.com/medline/citation/12168685/Vitamin_E_and_neurodegenerative_disorders_associated_with_oxidative_stress_ L2 - https://www.tandfonline.com/doi/full/10.1080/10284150290028954 DB - PRIME DP - Unbound Medicine ER -