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Regulation of human cranial osteoblast phenotype by FGF-2, FGFR-2 and BMP-2 signaling.
Histol Histopathol. 2002; 17(3):877-85.HH

Abstract

The formation of cranial bone requires the differentiation of osteoblasts from undifferentiated mesenchymal cells. The balance between osteoblast recruitment, proliferation, differentiation and apoptosis in sutures between cranial bones is essential for calvarial bone formation. The mechanisms that control human osteoblasts during normal calvarial bone formation and premature suture ossification (craniosynostosis) begin to be understood. Our studies of the human calvaria osteoblast phenotype and calvarial bone formation showed that premature fusion of the sutures in non-syndromic and syndromic (Apert syndrome) craniosynostoses results from precocious osteoblast differentiation. We showed that Fibroblast Growth Factor-2 (FGF-2), FGF receptor-2 (FGFR-2) and Bone Morphogenetic Protein-2 (BMP-2), three essential factors involved in skeletal development, regulate the proliferation, differentiation and apoptosis in human calvaria osteoblasts. Mechanisms that induce the differentiated osteoblast phenotype have also been identified in human calvaria osteoblasts. We demonstrated the implication of molecules (N-cadherin, Il-1) and signaling pathways (src, PKC) by which these local factors modulate human calvaria osteoblast differentiation and apoptosis. The identification of these essential signaling molecules provides new insights into the pathways controlling the differentiated osteoblast phenotype, and leads to a more comprehensive view in the mechanisms that control normal and premature cranial ossification in humans.

Authors+Show Affiliations

INSERM U349, Hopital Lariboisière, Paris, France. pierre.marie@inserm.lrb.ap-hop-paris.frNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

12168799

Citation

Marie, P J., et al. "Regulation of Human Cranial Osteoblast Phenotype By FGF-2, FGFR-2 and BMP-2 Signaling." Histology and Histopathology, vol. 17, no. 3, 2002, pp. 877-85.
Marie PJ, Debiais F, Haÿ E. Regulation of human cranial osteoblast phenotype by FGF-2, FGFR-2 and BMP-2 signaling. Histol Histopathol. 2002;17(3):877-85.
Marie, P. J., Debiais, F., & Haÿ, E. (2002). Regulation of human cranial osteoblast phenotype by FGF-2, FGFR-2 and BMP-2 signaling. Histology and Histopathology, 17(3), 877-85. https://doi.org/10.14670/HH-17.877
Marie PJ, Debiais F, Haÿ E. Regulation of Human Cranial Osteoblast Phenotype By FGF-2, FGFR-2 and BMP-2 Signaling. Histol Histopathol. 2002;17(3):877-85. PubMed PMID: 12168799.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regulation of human cranial osteoblast phenotype by FGF-2, FGFR-2 and BMP-2 signaling. AU - Marie,P J, AU - Debiais,F, AU - Haÿ,E, PY - 2002/8/10/pubmed PY - 2003/4/18/medline PY - 2002/8/10/entrez SP - 877 EP - 85 JF - Histology and histopathology JO - Histol Histopathol VL - 17 IS - 3 N2 - The formation of cranial bone requires the differentiation of osteoblasts from undifferentiated mesenchymal cells. The balance between osteoblast recruitment, proliferation, differentiation and apoptosis in sutures between cranial bones is essential for calvarial bone formation. The mechanisms that control human osteoblasts during normal calvarial bone formation and premature suture ossification (craniosynostosis) begin to be understood. Our studies of the human calvaria osteoblast phenotype and calvarial bone formation showed that premature fusion of the sutures in non-syndromic and syndromic (Apert syndrome) craniosynostoses results from precocious osteoblast differentiation. We showed that Fibroblast Growth Factor-2 (FGF-2), FGF receptor-2 (FGFR-2) and Bone Morphogenetic Protein-2 (BMP-2), three essential factors involved in skeletal development, regulate the proliferation, differentiation and apoptosis in human calvaria osteoblasts. Mechanisms that induce the differentiated osteoblast phenotype have also been identified in human calvaria osteoblasts. We demonstrated the implication of molecules (N-cadherin, Il-1) and signaling pathways (src, PKC) by which these local factors modulate human calvaria osteoblast differentiation and apoptosis. The identification of these essential signaling molecules provides new insights into the pathways controlling the differentiated osteoblast phenotype, and leads to a more comprehensive view in the mechanisms that control normal and premature cranial ossification in humans. SN - 0213-3911 UR - https://www.unboundmedicine.com/medline/citation/12168799/Regulation_of_human_cranial_osteoblast_phenotype_by_FGF_2_FGFR_2_and_BMP_2_signaling_ L2 - http://www.hh.um.es/Abstracts/Vol_17/17_3/17_3_877.htm DB - PRIME DP - Unbound Medicine ER -