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Transgenic mouse models of neurodegenerative disease: opportunities for therapeutic development.
Curr Neurol Neurosci Rep. 2002 Sep; 2(5):457-64.CN

Abstract

Neurodegenerative diseases present an extraordinary challenge for medicine due to the grave nature of these illnesses, their prevalence, and their impact on individuals and caregivers. The most common of these age-associated chronic illnesses are Alzheimer's disease (AD) and Parkinson's disease (PD); other examples include the prion disorders, amyotrophic lateral sclerosis (ALS), and the trinucleotide (CAG) repeat diseases. All of these diseases are characterized by well-defined clinical syndromes with progressive courses that reflect the dysfunction and eventual loss of specific neuronal populations. Current therapies provide only symptomatic relief; none significantly alter the course of disease. We describe here how transgenic mice designed to model these diseases have substantially contributed to the identification and validation of many promising new therapies, and conversely how they have quickly and cost effectively eliminated several targets with unrealized expectations.

Authors+Show Affiliations

Department of Pathology, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross Building Room 558, Baltimore, MD 21205, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

12169227

Citation

Jankowsky, Joanna L., et al. "Transgenic Mouse Models of Neurodegenerative Disease: Opportunities for Therapeutic Development." Current Neurology and Neuroscience Reports, vol. 2, no. 5, 2002, pp. 457-64.
Jankowsky JL, Savonenko A, Schilling G, et al. Transgenic mouse models of neurodegenerative disease: opportunities for therapeutic development. Curr Neurol Neurosci Rep. 2002;2(5):457-64.
Jankowsky, J. L., Savonenko, A., Schilling, G., Wang, J., Xu, G., & Borchelt, D. R. (2002). Transgenic mouse models of neurodegenerative disease: opportunities for therapeutic development. Current Neurology and Neuroscience Reports, 2(5), 457-64.
Jankowsky JL, et al. Transgenic Mouse Models of Neurodegenerative Disease: Opportunities for Therapeutic Development. Curr Neurol Neurosci Rep. 2002;2(5):457-64. PubMed PMID: 12169227.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Transgenic mouse models of neurodegenerative disease: opportunities for therapeutic development. AU - Jankowsky,Joanna L, AU - Savonenko,Alena, AU - Schilling,Gabriele, AU - Wang,Jiou, AU - Xu,Guilian, AU - Borchelt,David R, PY - 2002/8/10/pubmed PY - 2002/11/26/medline PY - 2002/8/10/entrez SP - 457 EP - 64 JF - Current neurology and neuroscience reports JO - Curr Neurol Neurosci Rep VL - 2 IS - 5 N2 - Neurodegenerative diseases present an extraordinary challenge for medicine due to the grave nature of these illnesses, their prevalence, and their impact on individuals and caregivers. The most common of these age-associated chronic illnesses are Alzheimer's disease (AD) and Parkinson's disease (PD); other examples include the prion disorders, amyotrophic lateral sclerosis (ALS), and the trinucleotide (CAG) repeat diseases. All of these diseases are characterized by well-defined clinical syndromes with progressive courses that reflect the dysfunction and eventual loss of specific neuronal populations. Current therapies provide only symptomatic relief; none significantly alter the course of disease. We describe here how transgenic mice designed to model these diseases have substantially contributed to the identification and validation of many promising new therapies, and conversely how they have quickly and cost effectively eliminated several targets with unrealized expectations. SN - 1528-4042 UR - https://www.unboundmedicine.com/medline/citation/12169227/Transgenic_mouse_models_of_neurodegenerative_disease:_opportunities_for_therapeutic_development_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=12169227.ui DB - PRIME DP - Unbound Medicine ER -