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Enhancement of the inducible NO synthase activation by retinoic acid is mimicked by RARalpha agonist in vivo.
Am J Physiol Endocrinol Metab. 2002 Sep; 283(3):E525-35.AJ

Abstract

We have previously shown that all-trans retinoic acid (atRA), the active metabolite of vitamin A, enhances the activation of the inducible nitric oxide synthase (NOS II) pathway, a component of innate immunity, in rats in vivo. We investigated the relative contribution of retinoic acid receptor-alpha (RARalpha) and retinoid X receptors (RXRs) to NOS II activation triggered by LPS. Five-day supplementation with 10 mg/kg of either atRA or the RARalpha selective agonist Ro-40-6055, but not with 10 mg/kg of the pan-RXR agonist Ro-25-7386, enhanced the LPS-induced NOS II mRNA, protein expression in liver, and plasma nitrite/nitrate concentration. Both atRA and the RARalpha agonist (but not the RXR agonist) increased the number of peripheral T helper lymphocytes and plasma interferon-gamma concentration. Synergism between retinoids and LPS on NOS II activation within an organ coincided with synergism on interferon regulatory factor-1 mRNA expression but not with the level of expression of the RARalpha protein. These results suggest that, in vivo, atRA activates NOS II through RARalpha and contributes to characterizing the complex effect of retinoids on the host inflammatory/immune response.

Authors+Show Affiliations

Unité Propre de Recherche et d'Enseignement Supérieur-Equipe d'Accueil 3447 Lésions-Réparation: Remodelage Cardiaque et Artériel, Faculté de Médecine, Université Henri Poincaré, Nancy I, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12169446

Citation

Seguin-Devaux, Carole, et al. "Enhancement of the Inducible NO Synthase Activation By Retinoic Acid Is Mimicked By RARalpha Agonist in Vivo." American Journal of Physiology. Endocrinology and Metabolism, vol. 283, no. 3, 2002, pp. E525-35.
Seguin-Devaux C, Devaux Y, Latger-Cannard V, et al. Enhancement of the inducible NO synthase activation by retinoic acid is mimicked by RARalpha agonist in vivo. Am J Physiol Endocrinol Metab. 2002;283(3):E525-35.
Seguin-Devaux, C., Devaux, Y., Latger-Cannard, V., Grosjean, S., Rochette-Egly, C., Zannad, F., Meistelman, C., Mertes, P. M., & Longrois, D. (2002). Enhancement of the inducible NO synthase activation by retinoic acid is mimicked by RARalpha agonist in vivo. American Journal of Physiology. Endocrinology and Metabolism, 283(3), E525-35.
Seguin-Devaux C, et al. Enhancement of the Inducible NO Synthase Activation By Retinoic Acid Is Mimicked By RARalpha Agonist in Vivo. Am J Physiol Endocrinol Metab. 2002;283(3):E525-35. PubMed PMID: 12169446.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enhancement of the inducible NO synthase activation by retinoic acid is mimicked by RARalpha agonist in vivo. AU - Seguin-Devaux,Carole, AU - Devaux,Yvan, AU - Latger-Cannard,Véronique, AU - Grosjean,Sandrine, AU - Rochette-Egly,Cécile, AU - Zannad,Faiez, AU - Meistelman,Claude, AU - Mertes,Paul-Michel, AU - Longrois,Dan, PY - 2002/8/10/pubmed PY - 2002/9/24/medline PY - 2002/8/10/entrez SP - E525 EP - 35 JF - American journal of physiology. Endocrinology and metabolism JO - Am. J. Physiol. Endocrinol. Metab. VL - 283 IS - 3 N2 - We have previously shown that all-trans retinoic acid (atRA), the active metabolite of vitamin A, enhances the activation of the inducible nitric oxide synthase (NOS II) pathway, a component of innate immunity, in rats in vivo. We investigated the relative contribution of retinoic acid receptor-alpha (RARalpha) and retinoid X receptors (RXRs) to NOS II activation triggered by LPS. Five-day supplementation with 10 mg/kg of either atRA or the RARalpha selective agonist Ro-40-6055, but not with 10 mg/kg of the pan-RXR agonist Ro-25-7386, enhanced the LPS-induced NOS II mRNA, protein expression in liver, and plasma nitrite/nitrate concentration. Both atRA and the RARalpha agonist (but not the RXR agonist) increased the number of peripheral T helper lymphocytes and plasma interferon-gamma concentration. Synergism between retinoids and LPS on NOS II activation within an organ coincided with synergism on interferon regulatory factor-1 mRNA expression but not with the level of expression of the RARalpha protein. These results suggest that, in vivo, atRA activates NOS II through RARalpha and contributes to characterizing the complex effect of retinoids on the host inflammatory/immune response. SN - 0193-1849 UR - https://www.unboundmedicine.com/medline/citation/12169446/Enhancement_of_the_inducible_NO_synthase_activation_by_retinoic_acid_is_mimicked_by_RARalpha_agonist_in_vivo_ L2 - http://journals.physiology.org/doi/full/10.1152/ajpendo.00008.2002?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -