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Coping with the cold: the cold shock response in the Gram-positive soil bacterium Bacillus subtilis.
Philos Trans R Soc Lond B Biol Sci. 2002 Jul 29; 357(1423):895-907.PT

Abstract

All organisms examined to date, respond to a sudden change in environmental temperature with a specific cascade of adaptation reactions that, in some cases, have been identified and monitored at the molecular level. According to the type of temperature change, this response has been termed heat shock response (HSR) or cold shock response (CSR). During the HSR, a specialized sigma factor has been shown to play a central regulatory role in controlling expression of genes predominantly required to cope with heat-induced alteration of protein conformation. In contrast, after cold shock, nucleic acid structure and proteins interacting with the biological information molecules DNA and RNA appear to play a major cellular role. Currently, no cold-specific sigma factor has been identified. Therefore, unlike the HSR, the CSR appears to be organized as a complex stimulon rather than resembling a regulon. This review has been designed to draw a refined picture of our current understanding of the CSR in Bacillus subtilis. Important processes such as temperature sensing, membrane adaptation, modification of the translation apparatus, as well as nucleoid reorganization and some metabolic aspects, are discussed in brief. Special emphasis is placed on recent findings concerning the nucleic acid binding cold shock proteins, which play a fundamental role, not only during cold shock adaptation but also under optimal growth conditions.

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Authors+Show Affiliations

Weber MH
Philipps-Universität Marburg, Department of Chemistry, Hans-Meerwein-Strasse, D-35032 Marburg, Germany.
Marahiel MA
No affiliation info available

MeSH

Adaptation, PhysiologicalAmino Acid SequenceBacillus subtilisBacterial ProteinsCold TemperatureGene Expression Regulation, BacterialHeat-Shock ProteinsMolecular Sequence DataProtein Conformation

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

12171653

Citation

Weber, Michael H W., and Mohamed A. Marahiel. "Coping With the Cold: the Cold Shock Response in the Gram-positive Soil Bacterium Bacillus Subtilis." Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, vol. 357, no. 1423, 2002, pp. 895-907.
Weber MH, Marahiel MA. Coping with the cold: the cold shock response in the Gram-positive soil bacterium Bacillus subtilis. Philos Trans R Soc Lond B Biol Sci. 2002;357(1423):895-907.
Weber, M. H., & Marahiel, M. A. (2002). Coping with the cold: the cold shock response in the Gram-positive soil bacterium Bacillus subtilis. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 357(1423), 895-907.
Weber MH, Marahiel MA. Coping With the Cold: the Cold Shock Response in the Gram-positive Soil Bacterium Bacillus Subtilis. Philos Trans R Soc Lond B Biol Sci. 2002 Jul 29;357(1423):895-907. PubMed PMID: 12171653.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coping with the cold: the cold shock response in the Gram-positive soil bacterium Bacillus subtilis. AU - Weber,Michael H W, AU - Marahiel,Mohamed A, PY - 2002/8/13/pubmed PY - 2003/2/28/medline PY - 2002/8/13/entrez SP - 895 EP - 907 JF - Philosophical transactions of the Royal Society of London. Series B, Biological sciences JO - Philos Trans R Soc Lond B Biol Sci VL - 357 IS - 1423 N2 - All organisms examined to date, respond to a sudden change in environmental temperature with a specific cascade of adaptation reactions that, in some cases, have been identified and monitored at the molecular level. According to the type of temperature change, this response has been termed heat shock response (HSR) or cold shock response (CSR). During the HSR, a specialized sigma factor has been shown to play a central regulatory role in controlling expression of genes predominantly required to cope with heat-induced alteration of protein conformation. In contrast, after cold shock, nucleic acid structure and proteins interacting with the biological information molecules DNA and RNA appear to play a major cellular role. Currently, no cold-specific sigma factor has been identified. Therefore, unlike the HSR, the CSR appears to be organized as a complex stimulon rather than resembling a regulon. This review has been designed to draw a refined picture of our current understanding of the CSR in Bacillus subtilis. Important processes such as temperature sensing, membrane adaptation, modification of the translation apparatus, as well as nucleoid reorganization and some metabolic aspects, are discussed in brief. Special emphasis is placed on recent findings concerning the nucleic acid binding cold shock proteins, which play a fundamental role, not only during cold shock adaptation but also under optimal growth conditions. SN - 0962-8436 UR - https://www.unboundmedicine.com/medline/citation/12171653/Coping_with_the_cold:_the_cold_shock_response_in_the_Gram_positive_soil_bacterium_Bacillus_subtilis_ DB - PRIME DP - Unbound Medicine ER -