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Continuous intrathecal infusion of baclofen in patients with spasticity caused by spinal cord injuries.
Neurosurg Rev. 2002 Aug; 25(4):228-30.NR

Abstract

The aim of this study was to determine the efficacy and safety of intrathecal baclofen therapy delivered by a programmable pump for the chronic treatment of spinal spasticity. Twelve patients with intractable spasticity caused by spinal cord injuries underwent implantation of a programmable continuous infusion pump after significant reduction in spasticity following an intrathecal test bolus of baclofen. No deaths or new permanent neurological deficits occurred following surgery or chronic intrathecal baclofen therapy. The follow-up (12 months) shows a reduction in rigidity in the lower limb of 2.0 points on the Ashworth scale and in the upper limb of 1.2 points. Muscle spasms were reduced from a mean preoperative score of 2.8 to a mean postoperative score of 1.0. In two cases, we observed postoperative catheter dislocation, a complication which could be corrected surgically. This study demonstrates that chronic intrathecal baclofen infusion is a safe and effective form of treatment of intractable spasticity in patients with spinal cord injury. There is considerable reduction in the risk of infection in view of the fact that interrogation and programming of the implanted programmed pumps is noninvasive.

Authors+Show Affiliations

Department of Neurosurgery, University Greifswald, Sauerbruchstrasse, Germany. alexeikorenkov@aol.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12172730

Citation

Korenkov, Alexei I., et al. "Continuous Intrathecal Infusion of Baclofen in Patients With Spasticity Caused By Spinal Cord Injuries." Neurosurgical Review, vol. 25, no. 4, 2002, pp. 228-30.
Korenkov AI, Niendorf WR, Darwish N, et al. Continuous intrathecal infusion of baclofen in patients with spasticity caused by spinal cord injuries. Neurosurg Rev. 2002;25(4):228-30.
Korenkov, A. I., Niendorf, W. R., Darwish, N., Glaeser, E., & Gaab, M. R. (2002). Continuous intrathecal infusion of baclofen in patients with spasticity caused by spinal cord injuries. Neurosurgical Review, 25(4), 228-30.
Korenkov AI, et al. Continuous Intrathecal Infusion of Baclofen in Patients With Spasticity Caused By Spinal Cord Injuries. Neurosurg Rev. 2002;25(4):228-30. PubMed PMID: 12172730.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Continuous intrathecal infusion of baclofen in patients with spasticity caused by spinal cord injuries. AU - Korenkov,Alexei I, AU - Niendorf,Wulf R, AU - Darwish,Nouralla, AU - Glaeser,Eberhard, AU - Gaab,Michael R, Y1 - 2002/04/13/ PY - 2002/02/12/received PY - 2002/03/07/accepted PY - 2002/8/13/pubmed PY - 2002/10/9/medline PY - 2002/8/13/entrez SP - 228 EP - 30 JF - Neurosurgical review JO - Neurosurg Rev VL - 25 IS - 4 N2 - The aim of this study was to determine the efficacy and safety of intrathecal baclofen therapy delivered by a programmable pump for the chronic treatment of spinal spasticity. Twelve patients with intractable spasticity caused by spinal cord injuries underwent implantation of a programmable continuous infusion pump after significant reduction in spasticity following an intrathecal test bolus of baclofen. No deaths or new permanent neurological deficits occurred following surgery or chronic intrathecal baclofen therapy. The follow-up (12 months) shows a reduction in rigidity in the lower limb of 2.0 points on the Ashworth scale and in the upper limb of 1.2 points. Muscle spasms were reduced from a mean preoperative score of 2.8 to a mean postoperative score of 1.0. In two cases, we observed postoperative catheter dislocation, a complication which could be corrected surgically. This study demonstrates that chronic intrathecal baclofen infusion is a safe and effective form of treatment of intractable spasticity in patients with spinal cord injury. There is considerable reduction in the risk of infection in view of the fact that interrogation and programming of the implanted programmed pumps is noninvasive. SN - 0344-5607 UR - https://www.unboundmedicine.com/medline/citation/12172730/Continuous_intrathecal_infusion_of_baclofen_in_patients_with_spasticity_caused_by_spinal_cord_injuries_ L2 - https://dx.doi.org/10.1007/s10143-002-0221-1 DB - PRIME DP - Unbound Medicine ER -