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Clusterin/apolipoprotein J is associated with cortical Lewy bodies: immunohistochemical study in cases with alpha-synucleinopathies.
Acta Neuropathol. 2002 Sep; 104(3):225-30.AN

Abstract

Clusterin/apolipoprotein J protein expression in cases with "alpha-synucleinopathies", such as Parkinson's disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA), was investigated using an immunohistochemical method for the labeling of multiple antigens. About 50% of the cortical Lewy bodies in the cases with DLB were immunoreactive for clusterin, whereas brain-stem Lewy bodies in PD and DLB were rarely associated with clusterin. Clusterin was also immunopositive in around 10% of the glial cytoplasmic inclusions (GCIs) in the cases with MSA. Colocalization of clusterin with alpha-synuclein in such bodies or inclusions was clearly correlated with the immunostaining pattern of alpha-synuclein. Subcellular localization of clusterin was almost completely overlapped with the homogeneous immunoreaction of alpha-synuclein in the cortical Lewy bodies; however, clusterin immunoreactivity was not detected in the halo or ring-like structures of the brain-stem Lewy bodies. Furthermore, some Lewy bodies with intense immunoreactivity for clusterin showed only a weak signal for alpha-synuclein. These results suggest that clusterin may modify the formation of alpha-synuclein-positive inclusion bodies such as Lewy bodies and GCIs, through a previously proposed chaperone property of clusterin.

Authors+Show Affiliations

Department of Neuropathology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. ksasaki@np.med.kyushu-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12172907

Citation

Sasaki, Kensuke, et al. "Clusterin/apolipoprotein J Is Associated With Cortical Lewy Bodies: Immunohistochemical Study in Cases With Alpha-synucleinopathies." Acta Neuropathologica, vol. 104, no. 3, 2002, pp. 225-30.
Sasaki K, Doh-ura K, Wakisaka Y, et al. Clusterin/apolipoprotein J is associated with cortical Lewy bodies: immunohistochemical study in cases with alpha-synucleinopathies. Acta Neuropathol. 2002;104(3):225-30.
Sasaki, K., Doh-ura, K., Wakisaka, Y., & Iwaki, T. (2002). Clusterin/apolipoprotein J is associated with cortical Lewy bodies: immunohistochemical study in cases with alpha-synucleinopathies. Acta Neuropathologica, 104(3), 225-30.
Sasaki K, et al. Clusterin/apolipoprotein J Is Associated With Cortical Lewy Bodies: Immunohistochemical Study in Cases With Alpha-synucleinopathies. Acta Neuropathol. 2002;104(3):225-30. PubMed PMID: 12172907.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clusterin/apolipoprotein J is associated with cortical Lewy bodies: immunohistochemical study in cases with alpha-synucleinopathies. AU - Sasaki,Kensuke, AU - Doh-ura,Katsumi, AU - Wakisaka,Yoshinobu, AU - Iwaki,Toru, Y1 - 2002/05/09/ PY - 2002/01/21/received PY - 2002/02/28/accepted PY - 2002/8/13/pubmed PY - 2002/10/18/medline PY - 2002/8/13/entrez SP - 225 EP - 30 JF - Acta neuropathologica JO - Acta Neuropathol VL - 104 IS - 3 N2 - Clusterin/apolipoprotein J protein expression in cases with "alpha-synucleinopathies", such as Parkinson's disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA), was investigated using an immunohistochemical method for the labeling of multiple antigens. About 50% of the cortical Lewy bodies in the cases with DLB were immunoreactive for clusterin, whereas brain-stem Lewy bodies in PD and DLB were rarely associated with clusterin. Clusterin was also immunopositive in around 10% of the glial cytoplasmic inclusions (GCIs) in the cases with MSA. Colocalization of clusterin with alpha-synuclein in such bodies or inclusions was clearly correlated with the immunostaining pattern of alpha-synuclein. Subcellular localization of clusterin was almost completely overlapped with the homogeneous immunoreaction of alpha-synuclein in the cortical Lewy bodies; however, clusterin immunoreactivity was not detected in the halo or ring-like structures of the brain-stem Lewy bodies. Furthermore, some Lewy bodies with intense immunoreactivity for clusterin showed only a weak signal for alpha-synuclein. These results suggest that clusterin may modify the formation of alpha-synuclein-positive inclusion bodies such as Lewy bodies and GCIs, through a previously proposed chaperone property of clusterin. SN - 0001-6322 UR - https://www.unboundmedicine.com/medline/citation/12172907/Clusterin/apolipoprotein_J_is_associated_with_cortical_Lewy_bodies:_immunohistochemical_study_in_cases_with_alpha_synucleinopathies_ L2 - https://dx.doi.org/10.1007/s00401-002-0546-4 DB - PRIME DP - Unbound Medicine ER -